All Outputs (35)

A design of experiments (DoE) approach to identify the influencing parameters that determine poly-D,L-lactic acid (PDLLA) electrospun scaffold morphologies (2017)
Journal Article
Ruiter, F. A. A., Alexander, C., Rose, F. R., & Segal, J. (2017). A design of experiments (DoE) approach to identify the influencing parameters that determine poly-D,L-lactic acid (PDLLA) electrospun scaffold morphologies. Biomedical Materials, 12(5), Article 055009. https://doi.org/10.1088/1748-605X/aa7b54

Electrospun fibrous materials have increasing applications in regenerative medicine due to the similarity of fibre constructs to the morphology of certain extracellular matrices. Although experimentally the electrospinning method is relatively simple... Read More about A design of experiments (DoE) approach to identify the influencing parameters that determine poly-D,L-lactic acid (PDLLA) electrospun scaffold morphologies.

A new photocrosslinkable polycaprolactone based ink for three dimensional inkjet printing (2016)
Journal Article
He, Y., Tuck, C., Prina, E., Kilsby, S., Christie, S. D., Edmondson, S., …Wildman, R. D. (2017). A new photocrosslinkable polycaprolactone based ink for three dimensional inkjet printing. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 105(6), 1645-1657. https://doi.org/10.1002/jbm.b.33699

A new type of photocrosslinkable polycaprolactone (PCL)-based ink that is suitable for three-dimensional (3D) inkjet printing has been developed. Photocrosslinkable PCL dimethylacrylate was synthesized and mixed with poly(ethylene glycol) diacrylate... Read More about A new photocrosslinkable polycaprolactone based ink for three dimensional inkjet printing.

Disc colours in field and cluster spiral galaxies at 0.5 ≲z≲ 0.8 (2016)
Journal Article
Cantale, N., Jablonka, P., Courbin, F., Rudnick, G., Zaritsky, D., Meylan, G., …Simard, L. (2016). Disc colours in field and cluster spiral galaxies at 0.5 ≲z≲ 0.8. Astronomy and Astrophysics, 589, Article A82. https://doi.org/10.1051/0004-6361/201525801

We present a detailed study of the colours of late-type galaxy discs for ten of the EDisCS galaxy clusters with 0.5 ≲ z ≲ 0.8. Our cluster sample contains 172 spiral galaxies, and our control sample is composed of 96 field disc galaxies. We deconvolv... Read More about Disc colours in field and cluster spiral galaxies at 0.5 ≲z≲ 0.8.

A detailed assessment of varying ejection rate on delivery efficiency of mesenchymal stem cells using narrow-bore needles (2016)
Journal Article

As the number of clinical trials exploring cell therapy rises, a thorough understanding of the limits of cell delivery is essential. We used an extensive toolset comprising various standard and multiplex assays for the assessment of cell delivery pos... Read More about A detailed assessment of varying ejection rate on delivery efficiency of mesenchymal stem cells using narrow-bore needles.

In vivo assessment of bone regeneration in alginate/bone ECM hydrogels with incorporated skeletal stem cells and single growth factors (2015)
Journal Article

Investigating NF-kappa B signaling in lung fibroblasts in 2D and 3D culture systems (2015)
Journal Article

Adapting the electrospinning process to provide three unique environments for a tri-layered in vitro model of the airway wall (2015)
Journal Article

Electrospinning is a highly adaptable method producing porous 3D fibrous scaffolds that can be exploited in in vitro cell culture. Alterations to intrinsic parameters within the process allow a high degree of control over scaffold characteristics inc... Read More about Adapting the electrospinning process to provide three unique environments for a tri-layered in vitro model of the airway wall.

Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds (2014)
Journal Article
Morris, G., Bridge, J., Eltboli, O., Lewis, M., Knox, A., Aylott, J. W., …Rose, F. R. (2014). Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds. AJP - Lung Cellular and Molecular Physiology, 307(1), Article L38-L47. https://doi.org/10.1152/ajplung.00318.2013

Human airway smooth muscle (HASM) contraction plays a central role in regulating airway resistance in both healthy and asthmatic bronchioles. In vitro studies that investigate the intricate mechanisms that regulate this contractile process are predom... Read More about Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds.

Evaluation of skeletal tissue repair, Part 1: Assessment of novel growth-factor-releasing hydrogels in an ex vivo chick femur defect model (2014)
Journal Article

Current clinical treatments for skeletal conditions resulting in large-scale bone loss include autograft or allograft, both of which have limited effectiveness. In seeking to address bone regeneration, several tissue engineering strategies have come... Read More about Evaluation of skeletal tissue repair, Part 1: Assessment of novel growth-factor-releasing hydrogels in an ex vivo chick femur defect model.

Evaluation of skeletal tissue repair, Part 2: Enhancement of skeletal tissue repair through dual-growth-factor-releasing hydrogels within an ex vivo chick femur defect model (2014)
Journal Article

There is an unmet need for improved, effective tissue engineering strategies to replace or repair bone damaged through disease or injury. Recent research has focused on developing biomaterial scaffolds capable of spatially and temporally releasing co... Read More about Evaluation of skeletal tissue repair, Part 2: Enhancement of skeletal tissue repair through dual-growth-factor-releasing hydrogels within an ex vivo chick femur defect model.

Self-reporting Scaffolds for 3-Dimensional Cell Culture (2013)
Journal Article

Culturing cells in 3D on appropriate scaffolds is thought to better mimic the in vivo microenvironment and increase cell-cell interactions. The resulting 3D cellular construct can often be more relevant to studying the molecular events and cell-cell... Read More about Self-reporting Scaffolds for 3-Dimensional Cell Culture.

Adjuvant chemotherapy for brain tumors delivered via a novel intra-cavity moldable polymer matrix (2013)
Journal Article
Rahman, C. V., Smith, S. J., Morgan, P. S., Langmack, K. A., Clarke, P. A., Ritchie, A. A., …Rahman, R. (2013). Adjuvant chemotherapy for brain tumors delivered via a novel intra-cavity moldable polymer matrix. PLoS ONE, 8(10), Article e77435. https://doi.org/10.1371/journal.pone.0077435

INTRODUCTION Polymer-based delivery systems offer innovative intra-cavity administration of drugs, with the potential to better target micro-deposits of cancer cells in brain parenchyma beyond the resected cavity. Here we evaluate clinical utility... Read More about Adjuvant chemotherapy for brain tumors delivered via a novel intra-cavity moldable polymer matrix.

Interconnectivity and permeability of supercritical fluid-foamed scaffolds and the effect of their structural properties on cell distribution (2013)
Journal Article

This study aims to investigate interconnectivity and permeability of scCO2-foamed scaffolds and the influence of structural scaffold properties on cell distribution. Supercritical fluid technology was utilized to fabricated scaffolds from 37 kDa, 53... Read More about Interconnectivity and permeability of supercritical fluid-foamed scaffolds and the effect of their structural properties on cell distribution.

Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition (2012)
Journal Article
Smith, S. J., Wilson, M., Ward, J. H., Rahman, C. V., Peet, A. C., Macarthur, D. C., …Rahman, R. (2012). Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition. PLoS ONE, 7(12), Article e52335. https://doi.org/10.1371/journal.pone.0052335

INTRODUCTION Physiologically relevant pre-clinical ex vivo models recapitulating CNS tumor micro-environmental complexity will aid development of biologically-targeted agents. We present comprehensive characterization of tumor aggregates generated... Read More about Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition.

Tissue transglutaminase (TG-2) modified amniotic membrane: A novel scaffold for biomedical applications (2012)
Journal Article

The amniotic membrane (AM) is considered as a natural cell culture substrate and has occasionally been exploited in regenerative medicine especially for ocular surface reconstruction and dermal wound healing applications. However, its use is limited... Read More about Tissue transglutaminase (TG-2) modified amniotic membrane: A novel scaffold for biomedical applications.