All Outputs (3)

Distinct small non-coding RNA landscape in the axons and released extracellular vesicles of developing primary cortical neurons and the axoplasm of adult nerves (2021)
Journal Article
Mesquita-Ribeiro, R., Fort, R. S., Rathbone, A., Farias, J., Lucci, C., James, V., …Dajas-Bailador, F. (2021). Distinct small non-coding RNA landscape in the axons and released extracellular vesicles of developing primary cortical neurons and the axoplasm of adult nerves. RNA Biology, 18(sup2), 832-855. https://doi.org/10.1080/15476286.2021.2000792

Neurons have highlighted the needs for decentralized gene expression and specific RNA function in somato-dendritic and axonal compartments, as well as in intercellular communication via extracellular vesicles (EVs). Despite advances in miRNA biology,... Read More about Distinct small non-coding RNA landscape in the axons and released extracellular vesicles of developing primary cortical neurons and the axoplasm of adult nerves.

Vinculin is required for neuronal mechanosensing but not for axon outgrowth (2021)
Journal Article
Wang, D. Y., Melero, C., Albaraky, A., Atherton, P., Jansen, K. A., Dimitracopoulos, A., …Ballestrem, C. (2021). Vinculin is required for neuronal mechanosensing but not for axon outgrowth. Experimental Cell Research, 407(2), Article 112805. https://doi.org/10.1016/j.yexcr.2021.112805

Integrin receptors are transmembrane proteins that bind to the extracellular matrix (ECM). In most animal cell types integrins cluster together with adaptor proteins at focal adhesions that sense and respond to external mechanical signals. In the cen... Read More about Vinculin is required for neuronal mechanosensing but not for axon outgrowth.

Functional Genomics of Axons and Synapses to Understand Neurodegenerative Diseases (2021)
Journal Article
Di Paolo, A., Garat, J., Eastman, G., Farias, J., Dajas-Bailador, F., Smircich, P., & Sotelo-Silveira, J. R. (2021). Functional Genomics of Axons and Synapses to Understand Neurodegenerative Diseases. Frontiers in Cellular Neuroscience, 15, Article 686722. https://doi.org/10.3389/fncel.2021.686722

Functional genomics studies through transcriptomics, translatomics and proteomics have become increasingly important tools to understand the molecular basis of biological systems in the last decade. In most cases, when these approaches are applied to... Read More about Functional Genomics of Axons and Synapses to Understand Neurodegenerative Diseases.