Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer

Lothion-Roy, Jennifer; Haigh, Daisy B.; Harris, Anna E.; Metzler, Veronika M.; Alsaleem, Mansour; Toss, Michael S.; Kariri, Yousif; Ntekim, Atara; Robinson, Brian D.; Khani, Francesca; Gudas, Lorraine J.; Allegrucci, Cinzia; James, Victoria H.; Madhusudan, Srinivasan; Mather, Melissa; Emes, Richard D.; Archer, Nathan; Fray, Rupert G.; Rakha, Emad; Jeyapalan, Jennie N.; Rutland, Catrin S.; Mongan, Nigel P.; Woodcock, Corinne L.

doi:10.3389/fgene.2022.1096071

All Outputs (5)

Characteristics and prognostic significance of polo-like kinase-1 (PLK1) expression in breast cancer (2023)
Journal Article

Background: Polo-like kinase-1 (PLK1) plays a crucial role in cell cycle progression,and it is considered a potential therapeutic target in many cancers. Although the role of PLK1 is well established in triple negative breast cancer (TNBC) as an onco... Read More about Characteristics and prognostic significance of polo-like kinase-1 (PLK1) expression in breast cancer.

High Inner Centromere Protein Expression Correlates with Aggressive Features and Predicts Poor Prognosis in Patients with Invasive Breast Cancer (2023)
Journal Article

Introduction: Inner centromere protein (INCENP) is a member of the chromosomal passenger complex (CPC) and plays a key role in mitosis and cell proliferation. This study aims to evaluate the clinical and prognostic significance of INCENP in invasive... Read More about High Inner Centromere Protein Expression Correlates with Aggressive Features and Predicts Poor Prognosis in Patients with Invasive Breast Cancer.

Combined proliferation and apoptosis index provides better risk stratification in breast cancer (2023)
Journal Article

Aims: Breast cancer (BC) risk stratification is critical for predicting behaviour and guiding management decision-making. Despite the well-established prognostic value of cellular proliferation in BC, the interplay between proliferation and apoptosis... Read More about Combined proliferation and apoptosis index provides better risk stratification in breast cancer.

The clinical value of progesterone receptor expression in luminal breast cancer: A study of a large cohort with long-term follow-up (2023)
Journal Article

Background: The routine assessment of progesterone receptor (PR) expression in breast cancer (BC) remains controversial. This study aimed to evaluate the role of PR expression in luminal BC, with emphasis on the definition of positivity and its progn... Read More about The clinical value of progesterone receptor expression in luminal breast cancer: A study of a large cohort with long-term follow-up.

Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer (2023)
Journal Article

N6-methyladenosine (m6A) is the most abundant internal mRNA modification and is dynamically regulated through distinct protein complexes that methylate, demethylate, and/or interpret the m6A modification. These proteins, and the m6A modification, are... Read More about Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer.