All Outputs (10)

The biomolecules of Euglena gracilis: Harnessing biology for natural solutions to future problems (2024)
Journal Article

Over the past decade, the autotrophic and heterotrophic protist Euglena gracilis (E. gracilis) has gained popularity across the studies of environmental science, biosynthesis experiments, and nutritional substitutes. The unique physiology and versati... Read More about The biomolecules of Euglena gracilis: Harnessing biology for natural solutions to future problems.

microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data (2024)
Journal Article

microbeMASST, a taxonomically informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of >60,000 microbial monocultures, users can search known... Read More about microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data.

Glycosylated proteins in the protozoan alga Euglena gracilis: a proteomic approach (2022)
Journal Article

Protein glycosylation, and in particular N-linked glycans, is a hallmark of eukaryotic cells and has been well-studied in mammalian cells and parasites. However, little research has been conducted to investigate the conservation and variation of prot... Read More about Glycosylated proteins in the protozoan alga Euglena gracilis: a proteomic approach.

Euglena International Network (EIN): Driving euglenoid biotechnology for the benefit of a challenged world (2022)
Journal Article

Euglenoids (Euglenida) are unicellular flagellates possessing exceptionally wide geographical and ecological distribution. Euglenoids combine a biotechnological potential with a unique position in the eukaryotic tree of life. In large part these micr... Read More about Euglena International Network (EIN): Driving euglenoid biotechnology for the benefit of a challenged world.

Euglenatides, Potent Antiproliferative Cyclic Peptides Isolated from the Freshwater Photosynthetic Microalga Euglena gracilis (2022)
Journal Article

By limiting the nitrogen source to glutamic acid, we isolated cyclic peptides from Euglena gracilis containing asparagine and non-proteinogenic amino acids. Structure elucidation was accomplished through spectroscopic methods, mass spectrometry and c... Read More about Euglenatides, Potent Antiproliferative Cyclic Peptides Isolated from the Freshwater Photosynthetic Microalga Euglena gracilis.

A community resource for paired genomic and metabolomic data mining (2021)
Journal Article

Transcriptome, proteome and draft genome of Euglena gracilis (2019)
Journal Article

Background Photosynthetic euglenids are major contributors to fresh water ecosystems. Euglena gracilis in particular has noted metabolic flexibility, reflected by an ability to thrive in a range of harsh environments. E. gracilis has been a popular... Read More about Transcriptome, proteome and draft genome of Euglena gracilis.

Prioritizing Natural Product Diversity in a Collection of 146 Bacterial Strains Based on Growth and Extraction Protocols (2016)
Journal Article

In order to expedite the rapid and efficient discovery and isolation of novel specialized metabolites, while minimizing the waste of resources on rediscovery of known compounds, it is crucial to develop efficient approaches for strain prioritization,... Read More about Prioritizing Natural Product Diversity in a Collection of 146 Bacterial Strains Based on Growth and Extraction Protocols.

Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining (2015)
Journal Article

Recent genome sequencing efforts have led to the rapid accumulation of uncharacterized or “orphaned” secondary metabolic biosynthesis gene clusters (BGCs) in public databases. This increase in DNA-sequenced big data has given rise to significant chal... Read More about Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining.

The transcriptome of Euglena gracilis reveals unexpected metabolic capabilities for carbohydrate and natural product biochemistry (2015)
Journal Article

Euglena gracilis is a highly complex alga belonging to the green plant line that shows characteristics of both plants and animals, while in evolutionary terms it is most closely related to the protozoan parasites Trypanosoma and Leishmania. This well... Read More about The transcriptome of Euglena gracilis reveals unexpected metabolic capabilities for carbohydrate and natural product biochemistry.