All Outputs (52)

Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana (2017)
Journal Article

Amphotericin B has emerged as the therapy of choice for use against the leishmaniases. Administration of the drug in its liposomal formulation as a single injection is being promoted in a campaign to bring the leishmaniases under control. Understandi... Read More about Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana.

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis (2017)
Journal Article

Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide. We performed a genetic association study in 15,256 cases and 47,936 controls, with replication of select top results (P < 5 × 10(-6)) in 9,498 cases and 9,748 con... Read More about Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.

Evidence for large-scale gene-by-smoking interaction effects on pulmonary function (2017)
Journal Article

Background: Smoking is the strongest environmental risk factor for reduced pulmonary function. The genetic component of various pulmonary traits has also been demonstrated, and at least 26 loci have been reproducibly associated with either FEV1 (forc... Read More about Evidence for large-scale gene-by-smoking interaction effects on pulmonary function.

Outcomes following first-episode psychosis: why we should intervene early in all ages, not only in youth (2016)
Journal Article

Objective: To compare baseline demographics and 10-year outcomes of a first-episode psychosis patient incidence cohort in order to establish whether current youth-focussed age-based criteria for early intervention services are justified by patient ne... Read More about Outcomes following first-episode psychosis: why we should intervene early in all ages, not only in youth.

Exercise for reducing fear of falling in older people living in the community: Cochrane systematic review and meta-analysis (2016)
Journal Article

Objective: To determine the effect of exercise interventions on fear of falling in community-living people aged ?65 years. Design: Systematic review and meta-analysis. Bibliographic databases, trial registers and other sources were searched for ra... Read More about Exercise for reducing fear of falling in older people living in the community: Cochrane systematic review and meta-analysis.

Non-destructive characterisation of mesenchymal stem cell differentiation using LC-MS-based metabolite footprinting (2016)
Journal Article

Bone regeneration is a complex biological process where major cellular changes take place to support the osteogenic differentiation of mesenchymal bone progenitors. To characterise these biological changes and better understand the pathways regulatin... Read More about Non-destructive characterisation of mesenchymal stem cell differentiation using LC-MS-based metabolite footprinting.

LC–MS-based absolute metabolite quantification: application to metabolic flux measurement in trypanosomes (2015)
Journal Article

Human African trypanosomiasis is a neglected tropical disease caused by the protozoan parasite, Trypanosoma brucei. In the mammalian bloodstream, the trypanosome’s metabolism differs significantly from that of its host. For example, the parasite reli... Read More about LC–MS-based absolute metabolite quantification: application to metabolic flux measurement in trypanosomes.

Probing the Metabolic Network in Bloodstream-Form Trypanosoma brucei Using Untargeted Metabolomics with Stable Isotope Labelled Glucose (2015)
Journal Article

Metabolomics coupled with heavy-atom isotope-labelled glucose has been used to probe the metabolic pathways active in cultured bloodstream form trypomastigotes of Trypanosoma brucei, a parasite responsible for human African trypanosomiasis. Glucose e... Read More about Probing the Metabolic Network in Bloodstream-Form Trypanosoma brucei Using Untargeted Metabolomics with Stable Isotope Labelled Glucose.

Potent trypanocidal curcumin analogs bearing a mono-enone linker Motif act on Trypanosoma brucei by forming an adduct with trypanothione (2015)
Journal Article

We have previously reported that curcumin analogs with a C7 linker bearing a C4-C5 olefinic linker with a single keto group at C3 (enone linker) display midnanomolar activity against the bloodstream form of Trypanosoma brucei. However, no clear indic... Read More about Potent trypanocidal curcumin analogs bearing a mono-enone linker Motif act on Trypanosoma brucei by forming an adduct with trypanothione.

Investigating gender differences in the factor structure of the Gudjonsson Compliance Scale (2015)
Journal Article

Purpose: The Gudjonsson Compliance Scale (GCS) remains, in terms of its psychometrics, an under-researched instrument, in which gender differences in particular have been insufficiently examined. The aim of this research was to therefore investigate... Read More about Investigating gender differences in the factor structure of the Gudjonsson Compliance Scale.

Exercise for reducing fear of falling in older people living in the community (2014)
Journal Article

Background: Fear of falling is common in older people and associated with serious physical and psychosocial consequences. Exercise (planned, structured, repetitive and purposive physical activity aimed at improving physical fitness) may reduce fear o... Read More about Exercise for reducing fear of falling in older people living in the community.

A metabolomics investigation into the effects of HIV protease inhibitors on HPV16 E6 expressing cervical carcinoma cells (2014)
Journal Article

Recently, it has been reported that anti-viral drugs, such as indinavir and lopinavir (originally targeted for HIV), also inhibit E6-mediated proteasomal degradation of mutant p53 in E6-transfected C33A cells. In order to understand more about the mo... Read More about A metabolomics investigation into the effects of HIV protease inhibitors on HPV16 E6 expressing cervical carcinoma cells.