All Outputs (155)

The role of oral antibiotic preparation in elective colorectal surgery: a meta-analysis (2018)
Journal Article

© 2018 The Author(s). Published by Wolters Kluwer Health, Inc. Objectives:To compare the impact of the use of oral antibiotics (OAB) with or without mechanical bowel preparation (MBP) on outcome in elective colorectal surgery.Summary Background Data:... Read More about The role of oral antibiotic preparation in elective colorectal surgery: a meta-analysis.

Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations: 2018 (2018)
Journal Article

Background: This is the fourth updated Enhanced Recovery After Surgery (ERAS®) Society guideline presenting a consensus for optimal perioperative care in colorectal surgery and providing graded recommendations for each ERAS item within the ERAS® prot... Read More about Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations: 2018.

Intestinal failure in adults: recommendations from the ESPEN Expert Groups (2018)
Journal Article

Background and aims: Intestinal failure (IF) is defined as “the reduction of gut function below the minimum necessary for the absorption of macronutrients and/or water and electrolytes, such that intravenous supplementation is required to maintain h... Read More about Intestinal failure in adults: recommendations from the ESPEN Expert Groups.

The reporting on ERAS Compliance, Outcomes, and Elements Research (RECOvER) checklist: a joint statement by the ERAS® and ERAS® USA societies (2018)
Journal Article

Background: Enhanced Recovery After Surgery (ERAS) programs are multimodal care pathways designed to minimize the physiologic and psychological impact of surgery for patients. Increased compliance with ERAS guidelines is associated with improved pati... Read More about The reporting on ERAS Compliance, Outcomes, and Elements Research (RECOvER) checklist: a joint statement by the ERAS® and ERAS® USA societies.

A comparison of two different software packages for the analysis of body composition using computed tomography images (2018)
Journal Article

Objectives: Body composition analysis from computed tomography (CT) imaging has become widespread. However, the methodology used is far from established. Two main software packages are in common usage for body composition analysis, with results used... Read More about A comparison of two different software packages for the analysis of body composition using computed tomography images.

Postoperative inflammation and insulin resistance in relation to body composition, adiposity and carbohydrate treatment: a randomised controlled study (2018)
Journal Article

Background and Aims: The aims of this study were to identify whether differences in distribution of adipose tissue and skeletal muscle in obese and non-obese individuals contribute to the magnitude of the postoperative inflammatory response and insul... Read More about Postoperative inflammation and insulin resistance in relation to body composition, adiposity and carbohydrate treatment: a randomised controlled study.

PET-PANC: multicentre prospective diagnostic accuracy and health economic analysis study of the impact of combined modality 18fluorine-2-fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography scanning in the diagnosis and management of pancreatic cancer (2018)
Journal Article

Background: Pancreatic cancer diagnosis and staging can be difficult in 10–20% of patients. Positron emission tomography (PET)/computed tomography (CT) adds precise anatomical localisation to functional data. The use of PET/CT may add further value t... Read More about PET-PANC: multicentre prospective diagnostic accuracy and health economic analysis study of the impact of combined modality 18fluorine-2-fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography scanning in the diagnosis and management of pancreatic cancer.

Impact of mechanical bowel preparation in elective colorectal surgery: a meta-analysis (2018)
Journal Article

AIM: To analyse the effect of mechanical bowel preparation vs no mechanical bowel preparation on outcome in patients undergoing elective colorectal surgery. METHODS: Meta-analysis of randomised controlled trials and observational studies comparing a... Read More about Impact of mechanical bowel preparation in elective colorectal surgery: a meta-analysis.

Consensus on Training and Implementation of Enhanced Recovery After Surgery: A Delphi Study (2018)
Journal Article

Background Enhanced Recovery After Surgery (ERAS) is widely accepted in current surgical practice due to its positive impact on patient outcomes. The successful implementation of ERAS is chal-lenging and compliance with protocols varies widely. Cont... Read More about Consensus on Training and Implementation of Enhanced Recovery After Surgery: A Delphi Study.

Inflammation-mediated muscle metabolic dysregulation local and remote to the site of major abdominal surgery (2017)
Journal Article

Background & aims: Postoperative hyperglycaemia is common in patients having major surgery and is associated with adverse outcomes. This study aimed to determine whether bacteraemia contributed to postoperative systemic inflammation, and whether incr... Read More about Inflammation-mediated muscle metabolic dysregulation local and remote to the site of major abdominal surgery.

Development of a telehealth monitoring service after colorectal surgery: a feasibility study (2017)
Journal Article

AIM: To evaluate the feasibility of a text-messaging system to remotely monitor and support patients after discharge following elective colorectal surgery, within an enhanced recovery protocol. METHODS: Florence (FLO) is a National Health Service te... Read More about Development of a telehealth monitoring service after colorectal surgery: a feasibility study.

Pancreas preserving distal duodenectomy: a versatile operation for a range of infra-papillary pathologies (2017)
Journal Article

AIM To investigate the range of pathologies treated by pancreas preserving distal duodenectomy (PPDD) and present the outcome of follow-up. METHODS Neoplastic lesions of the duodenum are treated conventionally by pancreaticoduodenectomy. Les... Read More about Pancreas preserving distal duodenectomy: a versatile operation for a range of infra-papillary pathologies.

Spontaneous central venous thrombosis and shunt occlusion following peritoneovenous shunt placement for intractable ascites (2017)
Journal Article

A 43-year-old man had a peritoneovenous shunt inserted for the treatment of chylous ascites secondary to myelofibrosis. Despite being on anticoagulation for superior mesenteric vein thrombosis, he developed shunt dysfunction within two weeks of inser... Read More about Spontaneous central venous thrombosis and shunt occlusion following peritoneovenous shunt placement for intractable ascites.

Spontaneous extrusion of gallstones after percutaneous drainage (2017)
Journal Article

There have been reports of late discharge of gallstones through operative wounds after spillage into the peritoneal cavity during laparoscopic cholecystectomy and after the development of spontaneous cholecystocutaneous fistulae. However, spontaneous... Read More about Spontaneous extrusion of gallstones after percutaneous drainage.

The Impact of Sarcopenia and Myosteatosis on Outcomes of Unresectable Pancreatic Cancer or Distal 1 Cholangiocarcinoma (2016)
Journal Article

Abstract Background and aims: Patients with pancreatic cancer have a poor prognosis, are often cachectic, and frequently demonstrate features of systemic inflammation, which may contribute to the phenomenon of myosteatosis. Analysis of body compos... Read More about The Impact of Sarcopenia and Myosteatosis on Outcomes of Unresectable Pancreatic Cancer or Distal 1 Cholangiocarcinoma.

Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde cholangiopancreatography (2016)
Journal Article

© 2016 The Author(s). This prospective observational study investigated monocyte cytokine responses to lipopolysaccharide (LPS) in patients with obstructive jaundice (OJ) before and after endoscopic biliary drainage. Dendritic cell (DC) subsets and t... Read More about Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde cholangiopancreatography.

Major abdominal surgery in Jehovah’s Witnesses (2016)
Journal Article

Introduction Patients who are Jehovah’s Witnesses pose difficult ethical and moral dilemmas for surgeons because of their refusal to receive blood and blood products. This article outlines the personal experiences of six Jehovah’s Witnesses who un... Read More about Major abdominal surgery in Jehovah’s Witnesses.

Human helicase RECQL4 drives cisplatin resistance in gastric cancer by activating an AKT-YB1-MDR1 signaling pathway (2016)
Journal Article

Elevation of the DNA-unwinding helicase RECQL4, which participates in various DNA repair pathways, has been suggested to contribute to the pathogenicity of various human cancers, including gastric cancer. In this study, we addressed the prognostic an... Read More about Human helicase RECQL4 drives cisplatin resistance in gastric cancer by activating an AKT-YB1-MDR1 signaling pathway.

A dangerous loop (2016)
Journal Article

Key Clinical Message: A 76-year-old man developed a hemoperitoneum after ERCP for choledocholithiasis. He underwent a laparotomy and splenectomy for a capsular tear at the splenic hilum, a rare complication of ERCP. “Bowing” of the endoscope with to... Read More about A dangerous loop.

3-dimensional patient-derived lung cancer assays reveal resistance to standards-of-care promoted by stromal cells but sensitivity to histone deacetylase inhibitors (2016)
Journal Article

There is a growing recognition that current preclinical models do not reflect the tumor microenvironment in cellular, biological, and biophysical content and this may have a profound effect on drug efficacy testing, especially in the era of molecular... Read More about 3-dimensional patient-derived lung cancer assays reveal resistance to standards-of-care promoted by stromal cells but sensitivity to histone deacetylase inhibitors.