The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, in vitro, and in silico mechanistic investigations

Musa, Arafa; Ihmaid, Saleh K.; Hughes, David L.; Said, Musa A.; Abulkhair, Hamada S.; El-Ghorab, Ahmed H.; Abdelgawad, Mohamed A.; Shalaby, Khaled; Shaker, Mohamed E.; Alharbi, Khalid Saad; Alotaibi, Nasser Hadal; Kays, Deborah L.; Taylor, Laurence J.; Parambi, Della Grace Thomas; Alzarea, Sami I.; Al-Karmalawy, Ahmed A.; Ahmed, Hany E.A.; El-Agrody, Ahmed M.

doi:10.1080/07391102.2023.2167000

All Outputs (4)

Organoruthenium Complexes Containing Phosphinodicarboxamide Ligands (2023)
Journal Article
Nolla-Saltiel, R., Geer, A. M., Sharpe, H. R., Huke, C. D., Taylor, L. J., Linford-Wood, T. G., …Kays, D. L. (2023). Organoruthenium Complexes Containing Phosphinodicarboxamide Ligands. Inorganics, 11(9), Article 372. https://doi.org/10.3390/inorganics11090372

Ruthenium complexes of phosphinocarboxamide ligands, and their use to form metallacycles using halide abstraction/deprotonation reactions are reported. Thus, [Ru(p-cym){PPh2C(=O)NHR}Cl2; R = iPr (1), Ph (2), p-tol (3)] and [Ru(p-cym){PPh2C(=O)N(R)C(=... Read More about Organoruthenium Complexes Containing Phosphinodicarboxamide Ligands.

Homogeneous Carbon Monoxide Homologation (2023)
Book Chapter
Geer, A. M., Kays, D. L., & Taylor, L. J. (2023). Homogeneous Carbon Monoxide Homologation. In Homologation Reactions: Reagents, Applications, and Mechanisms (831-846). Wiley. https://doi.org/10.1002/9783527830237.ch23

The homogeneous activation and homologation of carbon monoxide remains a challenging and highly attractive area of chemical research. This is due in part to the fundamental synthetic interest of using highly reactive complexes, spanning the full brea... Read More about Homogeneous Carbon Monoxide Homologation.

Homotropic Cooperativity in Iron-Catalyzed Alkyne Cyclotrimerizations (2023)
Journal Article
Geer, A. M., Navarro, J., Alamán-Valtierra, P., Coles, N. T., Kays, D. L., & Tejel, C. (2023). Homotropic Cooperativity in Iron-Catalyzed Alkyne Cyclotrimerizations. ACS Catalysis, 13, 6610-6618. https://doi.org/10.1021/acscatal.3c00764

Enhancing catalytic activity through synergic effects is a current challenge in homogeneous catalysis. In addition to the well-established metal-metal and metal-ligand cooperation, we showcase here an example of self-activation by the substrate in co... Read More about Homotropic Cooperativity in Iron-Catalyzed Alkyne Cyclotrimerizations.

The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, in vitro, and in silico mechanistic investigations (2023)
Journal Article
Musa, A., Ihmaid, S. K., Hughes, D. L., Said, M. A., Abulkhair, H. S., El-Ghorab, A. H., …El-Agrody, A. M. (2023). The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, in vitro, and in silico mechanistic investigations. Journal of Biomolecular Structure and Dynamics, https://doi.org/10.1080/07391102.2023.2167000

Treatment options for the management of breast cancer are still inadequate. This inadequacy is attributed to the lack of effective targeted medications, often resulting in the recurrence of metastatic disorders. Cumulative evidence suggests that epid... Read More about The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, in vitro, and in silico mechanistic investigations.