Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men

Mitchell, W. Kyle; Phillips, Bethan E.; Hill, Ian; Greenhaff, Paul L.; Lund, Jonathan N.; Williams, John P.; Rankin, Debbie; Wilkinson, Daniel J.; Smith, Kenneth; Atherton, Philip J.

doi:10.1042/CS20171230

All Outputs (1)

Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men (2017)
Journal Article
Mitchell, W. K., Phillips, B. E., Hill, I., Greenhaff, P. L., Lund, J. N., Williams, J. P., …Atherton, P. J. (2017). Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men. Clinical Science, 131(21), https://doi.org/10.1042/CS20171230

Leucine modulates muscle protein synthesis (MPS), with potential to facilitate accrual/maintenance of muscle mass. Animal models suggest that leucine boluses shortly after meals may prolong MPS and delay onset of a “muscle-full” state. However, the e... Read More about Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men.