Skip to main content

Research Repository

Advanced Search

All Outputs (12)

Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle (2020)
Journal Article
Abdulla, H., Phillips, B. E., Wilkinson, D. J., Limb, M., Jandova, T., Bass, J. J., …Atherton, P. J. (2020). Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle. Aging Cell, 19(9), Article e13202. https://doi.org/10.1111/acel.13202

© 2020 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd Background: Despite its known insulin-independent effects, glucagon-like peptide-1 (GLP-1) role in muscle protein turnover has not been explored under fed-stat... Read More about Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle.

Tart cherry concentrate does not enhance muscle protein synthesis response to exercise and protein in healthy older men (2018)
Journal Article
Jackman, S. R., Brook, M. S., Pulsford, R. M., Cockcroft, E. J., Campbell, M. I., Rankin, D., …Bowtell, J. L. (2018). Tart cherry concentrate does not enhance muscle protein synthesis response to exercise and protein in healthy older men. Experimental Gerontology, 110, 202-208. https://doi.org/10.1016/j.exger.2018.06.007

Background: Oxidative stress and inflammation may contribute to anabolic resistance in response to protein and exercise in older adults. We investigated whether consumption of montmorency cherry concentrate (MCC) increased anabolic sensitivity to pro... Read More about Tart cherry concentrate does not enhance muscle protein synthesis response to exercise and protein in healthy older men.

Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men (2017)
Journal Article
Mitchell, W. K., Phillips, B. E., Hill, I., Greenhaff, P. L., Lund, J. N., Williams, J. P., …Atherton, P. J. (2017). Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men. Clinical Science, 131(21), https://doi.org/10.1042/CS20171230

Leucine modulates muscle protein synthesis (MPS), with potential to facilitate accrual/maintenance of muscle mass. Animal models suggest that leucine boluses shortly after meals may prolong MPS and delay onset of a “muscle-full” state. However, the e... Read More about Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men.

Effects of leucine-enriched essential amino acid and whey protein bolus dosing upon skeletal muscle protein synthesis at rest and after exercise in older women (2017)
Journal Article
Wilkinson, D. J., Bukhari, S. S., Phillips, B. E., Limb, M. C., Cegielski, J., Brook, M. S., …Atherton, P. J. (2018). Effects of leucine-enriched essential amino acid and whey protein bolus dosing upon skeletal muscle protein synthesis at rest and after exercise in older women. Clinical Nutrition, 37(6), 2011-2021. https://doi.org/10.1016/j.clnu.2017.09.008

© 2017 The Authors Background & aims: Impaired anabolic responses to nutrition and exercise contribute to loss of skeletal muscle mass with ageing (sarcopenia). Here, we tested responses of muscle protein synthesis (MPS), in the under represented gr... Read More about Effects of leucine-enriched essential amino acid and whey protein bolus dosing upon skeletal muscle protein synthesis at rest and after exercise in older women.

Supplementing essential amino acids with the nitric oxide precursor, l-arginine, enhances skeletal muscle perfusion without impacting anabolism in older men (2016)
Journal Article
Mitchell, W. K., Phillips, B. E., Wilkinson, D. J., Williams, J. P., Rankin, D., Lund, J. N., …Atherton, P. J. (2017). Supplementing essential amino acids with the nitric oxide precursor, l-arginine, enhances skeletal muscle perfusion without impacting anabolism in older men. Clinical Nutrition, 36(6), https://doi.org/10.1016/j.clnu.2016.09.031

Postprandial limb blood flow and skeletal muscle microvascular perfusion reduce with aging. Here we tested the impact of providing bolus essential amino acids (EAA) in the presence and absence of the nitric oxide precursor, l-Arginine (ARG), upon ske... Read More about Supplementing essential amino acids with the nitric oxide precursor, l-arginine, enhances skeletal muscle perfusion without impacting anabolism in older men.

An overview of technical considerations for Western blotting applications to physiological research (2016)
Journal Article
Bass, J. J., Wilkinson, D. J., Rankin, D., Phillips, B. E., Szewczyk, N. J., Smith, K., & Atherton, P. J. (in press). An overview of technical considerations for Western blotting applications to physiological research. Scandinavian Journal of Medicine and Science in Sports, 27(1), https://doi.org/10.1111/sms.12702

The applications of Western/immuno-blotting (WB) techniques have reached multiple layers of the scientific community and are now considered routine procedures in the field of physiology. This is none more so than in relation to skeletal muscle physio... Read More about An overview of technical considerations for Western blotting applications to physiological research.

Enriching a protein drink with leucine augments muscle protein synthesis after resistance exercise in young and older men (2016)
Journal Article
Atherton, P. J., Kumar, V., Selby, A. L., Rankin, D., Hildebrandt, W., Phillips, B. E., …Smith, K. (2017). Enriching a protein drink with leucine augments muscle protein synthesis after resistance exercise in young and older men. Clinical Nutrition, 36(3), 888-895. https://doi.org/10.1016/j.clnu.2016.04.025

© 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism Maximizing anabolic responses to feeding and exercise is crucial for muscle maintenance and adaptation to exercise training. We hypothesized that enriching a protein drink... Read More about Enriching a protein drink with leucine augments muscle protein synthesis after resistance exercise in young and older men.

The impact of delivery profile of essential amino acids upon skeletal muscle protein synthesis in older men: clinical efficacy of pulse vs. bolus supply (2015)
Journal Article
Mitchell, W. K., Phillips, B. E., Williams, J. P., Rankin, D., Lund, J. N., Wilkinson, D. J., …Atherton, P. J. (2015). The impact of delivery profile of essential amino acids upon skeletal muscle protein synthesis in older men: clinical efficacy of pulse vs. bolus supply. AJP - Endocrinology and Metabolism, 309(5), Article E450-E457. https://doi.org/10.1152/ajpendo.00112.2015

Essential amino acids (EAA) are responsible for skeletal muscle anabolic effects after nutrient intake. The pattern of appearance of EAA in blood, e.g., after intake of “slow” or “fast” protein sources or in response to grazing vs. bolus feeding patt... Read More about The impact of delivery profile of essential amino acids upon skeletal muscle protein synthesis in older men: clinical efficacy of pulse vs. bolus supply.

Intake of low-dose leucine-rich essential amino acids stimulates muscle anabolism equivalently to bolus whey protein in older women at rest and after exercise (2015)
Journal Article
Bukhari, S. S., Phillips, B. E., Wilkinson, D. J., Limb, M. C., Rankin, D., Mitchell, W. K., …Atherton, P. J. (2015). Intake of low-dose leucine-rich essential amino acids stimulates muscle anabolism equivalently to bolus whey protein in older women at rest and after exercise. AJP - Endocrinology and Metabolism, 308(12), E1056-E1065. https://doi.org/10.1152/ajpendo.00481.2014

© 2015 American Physiological Society. All Rights Reseved. Dysregulated anabolic responses to nutrition/exercise may contribute to sarcopenia; however, these characteristics are poorly defined in female populations. We determined the effects of two f... Read More about Intake of low-dose leucine-rich essential amino acids stimulates muscle anabolism equivalently to bolus whey protein in older women at rest and after exercise.

A dose- rather than delivery profile-dependent mechanism regulates the "muscle-full" effect in response to oral essential amino acid intake in young men (2014)
Journal Article
Mitchell, W. K., Phillips, B. E., Williams, J. P., Rankin, D., Lund, J. N., Smith, K., & Atherton, P. J. (2015). A dose- rather than delivery profile-dependent mechanism regulates the "muscle-full" effect in response to oral essential amino acid intake in young men. Journal of Nutrition, 145(2), https://doi.org/10.3945/jn.114.199604

Background: The anabolic response of skeletal muscle to essential amino acids (EAAs) is dose dependent, maximal at modest doses, and short lived, even with continued EAA availability, a phenomenon termed “muscle-full.” However, the effect of EAA inge... Read More about A dose- rather than delivery profile-dependent mechanism regulates the "muscle-full" effect in response to oral essential amino acid intake in young men.

Development of a new SonovueTM contrast-enhanced ultrasound approach reveals temporal and age-related features of muscle microvascular responses to feeding (2013)
Journal Article
Mitchell, W. K., Phillips, B. E., Williams, J. P., Rankin, D., Smith, K., Lund, J. N., & Atherton, P. J. (2013). Development of a new SonovueTM contrast-enhanced ultrasound approach reveals temporal and age-related features of muscle microvascular responses to feeding. Physiological Reports, 1(5), Article e00119. https://doi.org/10.1002/phy2.119

Compromised limb blood flow in aging may contribute to the development of sarcopenia, frailty, and the metabolic syndrome. We developed a novel contrast-enhanced ultrasound technique using Sonovue™ to characterize muscle microvasculature responses to... Read More about Development of a new SonovueTM contrast-enhanced ultrasound approach reveals temporal and age-related features of muscle microvascular responses to feeding.