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Tart cherry concentrate does not enhance muscle protein synthesis response to exercise and protein in healthy older men

Jackman, Sarah R.; Brook, Matthew S.; Pulsford, Richard M.; Cockcroft, Emma J.; Campbell, Matthew I.; Rankin, Debbie; Atherton, Philip; Smith, Kenneth; Bowtell, Joanna L.


Sarah R. Jackman

Richard M. Pulsford

Emma J. Cockcroft

Matthew I. Campbell

Debbie Rankin

Professor of Clinical, metabolic & Molecular Physiology

Professor of Metabolic Mass Spectrometry

Joanna L. Bowtell


Background: Oxidative stress and inflammation may contribute to anabolic resistance in response to protein and exercise in older adults. We investigated whether consumption of montmorency cherry concentrate (MCC) increased anabolic sensitivity to protein ingestion and resistance exercise in healthy older men.
Methods: Sixteen healthy older men were randomized to receive MCC (60 mL·d−1) or placebo (PLA) for two weeks, after baseline measures in week 1. During week 3, participants consumed 10 g whey protein·d−1 and completed three bouts of unilateral leg resistance exercise (4 × 8–10 repetitions at 80% 1RM). Participants consumed a bolus (150 mL) and weekly (50 mL) doses of deuterated water. Body water 2H enrichment was measured in saliva and vastus lateralis biopsies were taken from the non-exercised leg after weeks 1, 2 and 3, and the exercised leg after week 3, to measure tracer incorporation at rest, in response to protein and protein + exercise.
Results: Myofibrillar protein synthesis increased in response to exercise + protein compared to rest (p 


Jackman, S. R., Brook, M. S., Pulsford, R. M., Cockcroft, E. J., Campbell, M. I., Rankin, D., …Bowtell, J. L. (2018). Tart cherry concentrate does not enhance muscle protein synthesis response to exercise and protein in healthy older men. Experimental Gerontology, 110, 202-208.

Journal Article Type Article
Acceptance Date Jun 7, 2018
Online Publication Date Jun 8, 2018
Publication Date Sep 30, 2018
Deposit Date Sep 10, 2018
Publicly Available Date Jun 9, 2019
Journal Experimental Gerontology
Print ISSN 0531-5565
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 110
Pages 202-208
Keywords Genetics; Cell Biology; Biochemistry; Ageing; Molecular Biology; Endocrinology
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