Tart cherry concentrate does not enhance muscle protein synthesis response to exercise and protein in healthy older men

Jackman, Sarah R.; Brook, Matthew S.; Pulsford, Richard M.; Cockcroft, Emma J.; Campbell, Matthew I.; Rankin, Debbie; Atherton, Philip; Smith, Kenneth; Bowtell, Joanna L.

Abstract

Background: Oxidative stress and inflammation may contribute to anabolic resistance in response to protein and exercise in older adults. We investigated whether consumption of montmorency cherry concentrate (MCC) increased anabolic sensitivity to protein ingestion and resistance exercise in healthy older men.
Methods: Sixteen healthy older men were randomized to receive MCC (60 mL·d−1) or placebo (PLA) for two weeks, after baseline measures in week 1. During week 3, participants consumed 10 g whey protein·d−1 and completed three bouts of unilateral leg resistance exercise (4 × 8–10 repetitions at 80% 1RM). Participants consumed a bolus (150 mL) and weekly (50 mL) doses of deuterated water. Body water 2H enrichment was measured in saliva and vastus lateralis biopsies were taken from the non-exercised leg after weeks 1, 2 and 3, and the exercised leg after week 3, to measure tracer incorporation at rest, in response to protein and protein + exercise.
Results: Myofibrillar protein synthesis increased in response to exercise + protein compared to rest (p 

Citation

Jackman, S. R., Brook, M. S., Pulsford, R. M., Cockcroft, E. J., Campbell, M. I., Rankin, D., …Bowtell, J. L. (2018). Tart cherry concentrate does not enhance muscle protein synthesis response to exercise and protein in healthy older men. Experimental Gerontology, 110, 202-208. https://doi.org/10.1016/j.exger.2018.06.007

• Journal Article Type: Article
• Acceptance Date: Jun 7, 2018
• Online Publication Date: Jun 8, 2018
• Publication Date: Sep 30, 2018
• Deposit Date: Sep 10, 2018
• Publicly Available Date: Jun 9, 2019
• Journal: Experimental Gerontology
• Print ISSN: 0531-5565
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 110
• Pages: 202-208
• DOI: https://doi.org/10.1016/j.exger.2018.06.007
• Keywords: Genetics; Cell Biology; Biochemistry; Ageing; Molecular Biology; Endocrinology
• Public URL: https://nottingham-repository.worktribe.com/output/1067816
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0531556517308409?via=ihub
• Contract Date: Sep 10, 2018