All Outputs (72)

Factors predicting pain and early discontinuation of tumour necrosis factor-α-inhibitors in people with rheumatoid arthritis: results from the British society for rheumatology biologics register (2016)
Journal Article
McWilliams, D. F., & Walsh, D. A. (2016). Factors predicting pain and early discontinuation of tumour necrosis factor-α-inhibitors in people with rheumatoid arthritis: results from the British society for rheumatology biologics register. BMC Musculoskeletal Disorders, 17(1), Article 337. https://doi.org/10.1186/s12891-016-1192-7

Background: We examined pain levels in 2 cohorts assembled from the British Society for Rheumatology Biologics Register (BSRBR), and investigated which factors predicted Bodily Pain scores and discontinuation of TNFα-inhibitors.
Method: Data were re... Read More about Factors predicting pain and early discontinuation of tumour necrosis factor-α-inhibitors in people with rheumatoid arthritis: results from the British society for rheumatology biologics register.

Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA) (2016)
Journal Article
Nwosu, L. N., Mapp, P. I., Chapman, V., & Walsh, D. A. (2016). Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA). Osteoarthritis and Cartilage, 24(11), 1910-1917. https://doi.org/10.1016/j.joca.2016.06.012

Objectives
To address the hypothesis that different types of established OA pain behaviours have associations with different aspects of articular pathology, we investigated the relationship between structural knee joint pathology and pain behaviour... Read More about Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA).

Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation (2016)
Journal Article
Alawi, K. M., Russell, F. A., Aubdool, A. A., Srivastava, S., Riffo-Vasquez, Y., Baldissera, L., …Brain, S. D. (2017). Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation. Annals of the Rheumatic Diseases, 76(1), 252-260. https://doi.org/10.1136/annrheumdis-2015-208886

Objective: Transient receptor potential canonical 5 (TRPC5) is functionally expressed on a range of cells including fibroblast-like synoviocytes, which play an important role in arthritis. A role for TRPC5 in inflammation has not been previously show... Read More about Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation.

Characterization of multinucleated giant cells in synovium and subchondral bone in knee osteoarthritis and rheumatoid arthritis (2015)
Journal Article
Prieto-Potin, I., Largo, R., Roman-Blas, J. A., Herrero-Beaumont, G., & Walsh, D. A. (2015). Characterization of multinucleated giant cells in synovium and subchondral bone in knee osteoarthritis and rheumatoid arthritis. BMC Musculoskeletal Disorders, 16, Article 226. https://doi.org/10.1186/s12891-015-0664-5

Background: Multinucleated giant cells have been noticed in diverse arthritic conditions since their first description in rheumatoid synovium. However, their role in the pathogenesis of osteoarthritis (OA) or rheumatoid arthritis (RA) still remains b... Read More about Characterization of multinucleated giant cells in synovium and subchondral bone in knee osteoarthritis and rheumatoid arthritis.

Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis (2015)
Journal Article
Nwosu, L. N., Mapp, P. I., Chapman, V., & Walsh, D. A. (in press). Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis. Annals of the Rheumatic Diseases, 75(6), https://doi.org/10.1136/annrheumdis-2014-207203

Objectives: Tropomyosin receptor kinase A (TrkA) mediates nociceptor sensitisation by nerve growth factor (NGF), but it is unknown whether selective TrkA inhibition will be an effective strategy for treating osteoarthritis (OA) pain. We determined th... Read More about Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis.

Pain Phenotype in Patients With Knee Osteoarthritis: Classification and Measurement Properties of painDETECT and Self-Report Leeds Assessment of Neuropathic Symptoms and Signs Scale in a Cross-Sectional Study (2015)
Journal Article
Moreton, B. J., Tew, V., das Nair, R., Wheeler, M., Walsh, D. A., & Lincoln, N. B. (2015). Pain Phenotype in Patients With Knee Osteoarthritis: Classification and Measurement Properties of painDETECT and Self-Report Leeds Assessment of Neuropathic Symptoms and Signs Scale in a Cross-Sectional Study. Arthritis Care and Research, 67(4), 519-528. https://doi.org/10.1002/acr.22431

Objective

Multiple mechanisms are involved in pain associated with osteoarthritis (OA). The painDETECT and Self‐Report Leeds Assessment of Neuropathic Symptoms and Signs (S‐LANSS) questionnaires screen for neuropathic pain and may also identify... Read More about Pain Phenotype in Patients With Knee Osteoarthritis: Classification and Measurement Properties of painDETECT and Self-Report Leeds Assessment of Neuropathic Symptoms and Signs Scale in a Cross-Sectional Study.

Dissecting the contribution of knee joint NGF to spinal nociceptive sensitization in a model of OA pain in the rat (2015)
Journal Article
Sagar, D. R., Nwosu, L. N., Walsh, D. A., & Chapman, V. (2015). Dissecting the contribution of knee joint NGF to spinal nociceptive sensitization in a model of OA pain in the rat. Osteoarthritis and Cartilage, 23(6), https://doi.org/10.1016/j.joca.2015.01.010

Objective: Although analgesic approaches targeting nerve growth factor (NGF) for the treatment of osteoarthritis (OA) pain remain of clinical interest, neurophysiological mechanisms by which NGF contribute to OA pain remain unclear. We investigated t... Read More about Dissecting the contribution of knee joint NGF to spinal nociceptive sensitization in a model of OA pain in the rat.

A cross-sectional study of pain sensitivity, disease-activity assessment, mental health, and fibromyalgia status in rheumatoid arthritis (2015)
Journal Article
Joharatnam, N., McWilliams, D. F., Wilson, D., Wheeler, M., Pande, I., & Walsh, D. A. (2015). A cross-sectional study of pain sensitivity, disease-activity assessment, mental health, and fibromyalgia status in rheumatoid arthritis. Arthritis Research and Therapy, 17(11), https://doi.org/10.1186/s13075-015-0525-5

INTRODUCTION: Pain remains the most important problem for people with rheumatoid arthritis (RA). Active inflammatory disease contributes to pain, but pain due to non-inflammatory mechanisms can confound the assessment of disease activity. We hypothes... Read More about A cross-sectional study of pain sensitivity, disease-activity assessment, mental health, and fibromyalgia status in rheumatoid arthritis.

Mechanisms, impact and management of pain in rheumatoid arthritis (2014)
Journal Article
Walsh, D. A., & McWilliams, D. F. (2014). Mechanisms, impact and management of pain in rheumatoid arthritis. Nature Reviews Rheumatology, 10(10), 581-592. https://doi.org/10.1038/nrrheum.2014.64

© 2014 Macmillan Publishers Limited. All rights reserved. People with rheumatoid arthritis (RA) identify pain as their most important symptom, one that often persists despite optimal control of inflammatory disease. RA pain arises from multiple mecha... Read More about Mechanisms, impact and management of pain in rheumatoid arthritis.

Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain (2013)
Journal Article
Kelly, S., Chapman, R., Woodhams, S., Sagar, D. R., Turner, J., Burston, J., …Chapman, V. (2014). Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain. Annals of the Rheumatic Diseases, 74, https://doi.org/10.1136/annrheumdis-2013-203413

Objectives Blockade of transient receptor potential vanilloid 1 (TRPV1) with systemic antagonists attenuates osteoarthritis (OA) pain behaviour in rat models, but on-target-mediated hyperthermia has halted clinical trials. The present study investiga... Read More about Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain.

Pain in rheumatoid arthritis (2012)
Journal Article
Walsh, D. A., & McWilliams, D. F. (2012). Pain in rheumatoid arthritis. Current Pain and Headache Reports, 16(6), 509-517. https://doi.org/10.1007/s11916-012-0303-x

Rheumatoid arthritis (RA) is an inflammatory disease of synovial joints, and pain is the predominant problem for people with RA. Pain in RA is distressing in its own right and adversely affects disability and psychosocial outcomes. RA pain may be due... Read More about Pain in rheumatoid arthritis.

Lymphatic vessels in osteoarthritic human knees (2012)
Journal Article
Walsh, D. A., Verghese, P., Cook, G. J., McWilliams, D. F., Mapp, P. I., Ashraf, S., & Wilson, D. (2012). Lymphatic vessels in osteoarthritic human knees. Osteoarthritis and Cartilage, 20(5), 405-412. https://doi.org/10.1016/j.joca.2012.01.012

Objectives: The distribution and function of lymphatic vessels in normal and diseased human knees are understood incompletely. This study aimed to investigate whether lymphatic density is associated with clinical, histological or radiographic paramet... Read More about Lymphatic vessels in osteoarthritic human knees.