All Outputs (55)

The Duration and Magnitude of Postdischarge Venous Thromboembolism Following Colectomy (2022)
Journal Article
Lewis-Lloyd, C. A., Humes, D. J., West, J., Peacock, O., & Crooks, C. J. (2022). The Duration and Magnitude of Postdischarge Venous Thromboembolism Following Colectomy. Annals of Surgery, 276(3), E177-E184. https://doi.org/10.1097/SLA.0000000000005563

Objective: To assess the impact of current guidelines by reporting weekly postoperative postdischarge venous thromboembolism (VTE) rates. Summary Background Data: Disparity exists between the postoperative thromboprophylaxis duration colectomy patien... Read More about The Duration and Magnitude of Postdischarge Venous Thromboembolism Following Colectomy.

Time Trends in the Incidence Rates of Venous Thromboembolism Following Colorectal Resection by Indication and Operative Technique (2022)
Journal Article
Lewis-Lloyd, C. A., Crooks, C. J., West, J., Peacock, O., & Humes, D. J. (2022). Time Trends in the Incidence Rates of Venous Thromboembolism Following Colorectal Resection by Indication and Operative Technique. Colorectal Disease, 24(11), 1405-1415. https://doi.org/10.1111/codi.16233

Aim
It is important for patient safety to assess if international changes in perioperative care, such as focus on venous thromboembolism (VTE) prevention and minimally invasive surgery have reduced the high post colectomy VTE risks previously report... Read More about Time Trends in the Incidence Rates of Venous Thromboembolism Following Colorectal Resection by Indication and Operative Technique.

Differences in progression by surgical specialty: A national cohort study (2022)
Journal Article
Hope, C., Lund, J., Griffiths, G., & Humes, D. (2022). Differences in progression by surgical specialty: A national cohort study. BMJ Open, 12(2), Article e053391. https://doi.org/10.1136/bmjopen-2021-053391

The aim of surgical training across the 10 surgical specialties is to produce competent day 1 consultants. Progression through training in the UK is assessed by the Annual Review of Competency Progression (ARCP). Objective This study aimed to examine... Read More about Differences in progression by surgical specialty: A national cohort study.

Planned surgery in the COVID-19 pandemic: a prospective cohort study from Nottingham (2021)
Journal Article
Catton, J., Banerjea, A., Gregory, S., Hall, C., Crooks, C., Lewis-Lloyd, C., Marshall, A., & Humes, D. (2021). Planned surgery in the COVID-19 pandemic: a prospective cohort study from Nottingham. Langenbeck's Archives of Surgery, 406, 2469-2477. https://doi.org/10.1007/s00423-021-02207-8

Purpose
Globally planned surgical procedures have been deferred during the current COVID-19 pandemic. The study aimed to report the outcomes of planned urgent and cancer cases during the current pandemic using a multi-disciplinary prioritisation gro... Read More about Planned surgery in the COVID-19 pandemic: a prospective cohort study from Nottingham.

Faecal immunochemical testing and blood tests for prioritization of urgent colorectal cancer referrals in symptomatic patients: a 2-year evaluation (2021)
Journal Article
Bailey, J. A., Weller, J., Chapman, C., Ford, A., Hardy, K., Oliver, S., Morling, J. R., Simpson, J. A., Humes, D. J., & Banerjea, A. (2021). Faecal immunochemical testing and blood tests for prioritization of urgent colorectal cancer referrals in symptomatic patients: a 2-year evaluation. BJS Open, 5(2), Article zraa056. https://doi.org/10.1093/bjsopen/zraa056

Background
A novel pathway incorporating faecal immunochemical testing (FIT) for rapid colorectal cancer diagnosis (RCCD) was introduced in 2017. This paper reports on the service evaluation after 2 years of pathway implementation.

Methods
The R... Read More about Faecal immunochemical testing and blood tests for prioritization of urgent colorectal cancer referrals in symptomatic patients: a 2-year evaluation.

Outcomes after non-operative management of perforated diverticular disease: a population-based cohort study (2021)
Journal Article
Adiamah, A., Ban, L., Otete, H., Crooks, C. J., West, J., & Humes, D. J. (2021). Outcomes after non-operative management of perforated diverticular disease: a population-based cohort study. BJS Open, 5(2), Article zraa073. https://doi.org/10.1093/bjsopen/zraa073

BACKGROUND: The management of perforated diverticular disease has changed in the past 10 years with a move towards less surgical intervention. This population-based cohort study aimed to define the risk of death and readmission following non-operativ... Read More about Outcomes after non-operative management of perforated diverticular disease: a population-based cohort study.

Choice of faecal immunochemical test matters: comparison of OC-Sensor and HM-JACKarc, in the assessment of patients at high risk of colorectal cancer (2020)
Journal Article
Chapman, C. J., Banerjea, A., Humes, D. J., Allen, J., Oliver, S., Ford, A., Hardy, K., Djedovic, N., Logan, R. F., & Morling, J. R. (2021). Choice of faecal immunochemical test matters: comparison of OC-Sensor and HM-JACKarc, in the assessment of patients at high risk of colorectal cancer. Clinical Chemistry and Laboratory Medicine, 59(4), 721-728. https://doi.org/10.1515/cclm-2020-1170

Objectives: Currently NICE recommends the use of faecal immunochemical test (FIT) at faecal haemoglobin concentrations (f-Hb) of 10 μg Hb/g faeces to stratify for colorectal cancer (CRC) risk in symptomatic populations. This f-Hb cut-off is advised a... Read More about Choice of faecal immunochemical test matters: comparison of OC-Sensor and HM-JACKarc, in the assessment of patients at high risk of colorectal cancer.

Factors Associated with Attrition and Performance Throughout Surgical Training: A Systematic Review and Meta-Analysis (2020)
Journal Article
Hope, C., Reilly, J.-J., Griffiths, G., Lund, J., & Humes, D. (2021). Factors Associated with Attrition and Performance Throughout Surgical Training: A Systematic Review and Meta-Analysis. World Journal of Surgery, 45, 429-442. https://doi.org/10.1007/s00268-020-05844-0

Background Attrition within surgical training is a challenge. In the USA, attrition rates are as high as 20-26%. The factors predicting attrition are not well known. The aim of this systematic review is to identify factors that influence attrition or... Read More about Factors Associated with Attrition and Performance Throughout Surgical Training: A Systematic Review and Meta-Analysis.

Mortality after extrahepatic gastrointestinal and abdominal wall surgery in patients with alcoholic liver disease: A systematic review and meta-analysis (2020)
Journal Article
Adiamah, A., Ban, L., Hammond, J., Jepsen, P., West, J., & Humes, D. .. (2020). Mortality after extrahepatic gastrointestinal and abdominal wall surgery in patients with alcoholic liver disease: A systematic review and meta-analysis. Alcohol and Alcoholism, 55(5), 497–511. https://doi.org/10.1093/alcalc/agaa043

Aims: This meta-analysis aimed to define the perioperative risk of mortality in patients with alcoholic liver disease (ALD) undergoing extrahepatic gastrointestinal surgery.

Methods: Systematic searches of Embase, Medline and CENTRAL were undertak... Read More about Mortality after extrahepatic gastrointestinal and abdominal wall surgery in patients with alcoholic liver disease: A systematic review and meta-analysis.

Thrombocytosis helps to stratify risk of colorectal cancer in patients referred on a 2-week-wait pathway (2020)
Journal Article
Bailey, J. A., Hanbali, N., Premji, K., Bunce, J., Mashlab, S., Simpson, J. A., Humes, D. J., & Banerjea, A. (2020). Thrombocytosis helps to stratify risk of colorectal cancer in patients referred on a 2-week-wait pathway. International Journal of Colorectal Disease, 35(7), 1347-1350. https://doi.org/10.1007/s00384-020-03597-9

Purpose
Primary care studies suggest that thrombocytosis (platelet counts > 400 × 109/L) is associated with an increased risk of colorectal cancer (CRC). We aimed to establish whether this marker has significant stratification value in patients seen... Read More about Thrombocytosis helps to stratify risk of colorectal cancer in patients referred on a 2-week-wait pathway.

GP access to FIT increases the proportion of colorectal cancers detected on urgent pathways in symptomatic patients in Nottingham (2020)
Journal Article
Bailey, J., Khawaja, A., Andrews, H., Weller, J., Chapman, C., Morling, J., Oliver, S., Castle, S., Simpson, J., Humes, D., & Banerjea, A. (2021). GP access to FIT increases the proportion of colorectal cancers detected on urgent pathways in symptomatic patients in Nottingham. The Surgeon, 19(2), 93-102. https://doi.org/10.1016/j.surge.2020.03.002

Objective
Service evaluation of GP access to Faecal Immunochemical Test (FIT) for colorectal cancer (CRC) detection in Nottinghamshire and use of FIT for “rule out”, “rule in” and “first test selection”.

Design
Retrospective audit of FIT results... Read More about GP access to FIT increases the proportion of colorectal cancers detected on urgent pathways in symptomatic patients in Nottingham.

Early clinical outcomes of a rapid colorectal cancer diagnosis pathway using faecal immunochemical testing in Nottingham (2019)
Journal Article
Chapman, C., Thomas, C., Morling, J., Tangri, A., Oliver, S., Simpson, J. A., Humes, D. J., & Banerjea, A. (2020). Early clinical outcomes of a rapid colorectal cancer diagnosis pathway using faecal immunochemical testing in Nottingham. Colorectal Disease, 22(6), 679-688. https://doi.org/10.1111/codi.14944

Hyperosmolar dehydration: a predictor of kidney injury and outcome in hospitalised older adults (2019)
Journal Article
El-Sharkawy, A. M., Devonald, M. A. J., Humes, D. J., Sahota, O., & Lobo, D. N. (2020). Hyperosmolar dehydration: a predictor of kidney injury and outcome in hospitalised older adults. Clinical Nutrition, 39(8), P2593-2599. https://doi.org/10.1016/j.clnu.2019.11.030

© 2019 The Author(s) Background & aims: Hospitalised older adults are vulnerable to dehydration. However, the prevalence of hyperosmolar dehydration (HD) and its impact on outcome is unknown. Serum osmolality is not measured routinely but osmolarity,... Read More about Hyperosmolar dehydration: a predictor of kidney injury and outcome in hospitalised older adults.

Diverticular disease (2019)
Journal Article
Humes, D., & Spiller, R. (2019). Diverticular disease. Medicine, 47(7), 424-427. https://doi.org/10.1016/j.mpmed.2019.04.005

© 2019 Colonic diverticula are formed by mucosal outpouching from the colonic wall. Their presence increases with increasing age with most, in Caucasian, being situated in the left colon. The aetiology of these outpouchings is not fully understood bu... Read More about Diverticular disease.

A pilot study of visceral fat and its association with adipokines, stool calprotectin and symptoms in patients with diverticulosis (2019)
Journal Article
Murray, K., Hoad, C., Garratt, J., Kaviani, M., Marciani, L., Smith, J., Siegmund, B., Gowland, P., Humes, D., & Spiller, R. (2019). A pilot study of visceral fat and its association with adipokines, stool calprotectin and symptoms in patients with diverticulosis. PLoS ONE, 14(5), Article e0216528. https://doi.org/10.1371/journal.pone.0216528

Background
Complications of diverticular disease are increasingly common, possibly linked to increasing obesity. Visceral fat could contribute to the development of symptomatic diverticular disease through its pro-inflammatory effects.

Objective... Read More about A pilot study of visceral fat and its association with adipokines, stool calprotectin and symptoms in patients with diverticulosis.

Duration and Magnitude of Postoperative Risk of Venous Thromboembolism after Cholecystectomy: A Population-Based Cohort Study (2019)
Journal Article
Henry, M., Abdul-Sultan, A., Walker, A., West, J., & Humes, D. (2019). Duration and Magnitude of Postoperative Risk of Venous Thromboembolism after Cholecystectomy: A Population-Based Cohort Study. Digestive Surgery, 37(1), 32-38. https://doi.org/10.1159/000496435

Background:
This study aimed to identify burden and risk of VTE associated with cholecystectomy in England.

Methods:
An historical cohort study of cholecystectomy patients from 2001-2011 was undertaken using linked primary (Clinical Practice... Read More about Duration and Magnitude of Postoperative Risk of Venous Thromboembolism after Cholecystectomy: A Population-Based Cohort Study.

A systematic review of population-based studies examining outcomes in primary retroperitoneal sarcoma surgery (2019)
Journal Article
Peacock, O., Patel, S., Simpson, J. A., Walter, C. J., & Humes, D. J. (2019). A systematic review of population-based studies examining outcomes in primary retroperitoneal sarcoma surgery. Surgical Oncology, 29, 53-63. https://doi.org/10.1016/j.suronc.2019.03.002

Retroperitoneal sarcomas (RPS) are rare mesenchymal tumours. Their rarity challenges our ability to understand expected outcomes. The aim of this systematic review was to examine 30-day morbidity and mortality, overall survival rates and prognostic p... Read More about A systematic review of population-based studies examining outcomes in primary retroperitoneal sarcoma surgery.

A service evaluation of FIT and anaemia for risk stratification in the two week wait pathway for colorectal cancer (2019)
Journal Article
Chapman, C., Bunce, J., Oliver, S., Ng, O., Tangri, A., Rogers, R., Logan, R., Humes, D., & Banerjea, A. (2019). A service evaluation of FIT and anaemia for risk stratification in the two week wait pathway for colorectal cancer. BJS Open, 3(3), 395-402. https://doi.org/10.1002/bjs5.50131

Introduction: New national guidance on urgent referral for investigation for Colorectal Cancer (CRC) included faecal occult blood testing in 2015. We evaluated faecal immunochemical testing (FIT) and anaemia as risk stratification tools in symptomati... Read More about A service evaluation of FIT and anaemia for risk stratification in the two week wait pathway for colorectal cancer.

Changing autonomy in operative experience through UK general surgery training: a national cohort study (2018)
Journal Article
Elsey, E. J., Griffiths, G., West, J., & Humes, D. J. (2019). Changing autonomy in operative experience through UK general surgery training: a national cohort study. Annals of Surgery, 269(3), 399-406. https://doi.org/10.1097/sla.0000000000003032

Objectives:To determine the operative experience of UK general surgery trainees and assess the changing procedural supervision and acquisition of competency assessments through the course of training.

Background Summary Data: Competency assessment... Read More about Changing autonomy in operative experience through UK general surgery training: a national cohort study.

Time out of general surgery specialty training in the UK: a national database study (2018)
Journal Article
Elsey, E. J., West, J., Griffiths, G., & Humes, D. J. (2019). Time out of general surgery specialty training in the UK: a national database study. Journal of Surgical Education, 76(1), 55-64. https://doi.org/10.1016/j.jsurg.2018.06.011

Objective:General surgery specialty training in the UK takes 6 years and allows trainees to take time out of training. Studies from the USA have highlighted an increasing trend for taking time out of surgical training for research. This study aimed t... Read More about Time out of general surgery specialty training in the UK: a national database study.