Tropomyosin 1: multiple roles in the developing heart and in the formation of congenital heart defects

England, Jennifer; Granados-Riveron, Javier T.; Polo-Parada, Luis; Kuriakose, Diji; Moore, Christopher; Brook, J. David; Rutland, Catrin S.; Setchfield, Kerry; Gell, Christopher; Ghosh, Tushar K.; Bu'Lock, Frances A.; Thornborough, Christopher; Ehler, Elisabeth; Loughna, Siobhan

doi:10.1016/j.yjmcc.2017.03.006

All Outputs (2)

Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development (2017)
Journal Article

© 2017 Elsevier Ltd TBX5 plays a critical role in heart and forelimb development. Mutations in TBX5 cause Holt-Oram syndrome, an autosomal dominant condition that affects the formation of the heart and upper-limb. Several studies have provided signif... Read More about Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development.

Tropomyosin 1: multiple roles in the developing heart and in the formation of congenital heart defects (2017)
Journal Article

Tropomyosin 1 (TPM1) is an essential sarcomeric component, stabilising the thin filament and facilitating actin's interaction with myosin. A number of sarcomeric proteins, such as alpha myosin heavy chain, play crucial roles in cardiac development. M... Read More about Tropomyosin 1: multiple roles in the developing heart and in the formation of congenital heart defects.