The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis

Ashraf, Sadaf; Radhi, Masar; Gowler, Peter; Burston, James J.; Gandhi, Raj D.; Thorn, Graeme J.; Piccinini, Anna M.; Walsh, David A.; Chapman, Victoria; De Moor, Cornelia H.; Chapman, Victoria

doi:10.1038/s41598-019-41140-1

All Outputs (3)

A novel nucleoside rescue metabolic pathway may be responsible for therapeutic effect of orally administered cordycepin (2019)
Journal Article

Although adenosine and its analogues have been assessed in the past as potential drug candidates due to the important role of adenosine in physiology, only little is known about their absorption following oral administration. In this work, we have st... Read More about A novel nucleoside rescue metabolic pathway may be responsible for therapeutic effect of orally administered cordycepin.

DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity (2019)
Journal Article

The CCR4–NOT complex plays an important role in the translational repression and deadenylation of mRNAs. However, little is known about the specific roles of interacting factors. We demonstrate that the DEAD-box helicases eIF4A2 and DDX6 interact dir... Read More about DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity.

The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis (2019)
Journal Article

Clinically, osteoarthritis (OA) pain is significantly associated with synovial inflammation. Identification of the mechanisms driving inflammation could reveal new targets to relieve this prevalent pain state. Herein, a role of polyadenylation in OA... Read More about The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis.