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All Outputs (22)

Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service (2024)
Journal Article

Background: Imaging is used to monitor disease activity in small bowel Crohn’s disease (CD). Magnetic Resonance Enterography is often employed as a first modality in the United Kingdom for assessment and monitoring; however, waiting times, cost, pati... Read More about Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service.

Enhancing emotion regulation with an in situ socially assistive robot among LGBTQ+ youth with self-harm ideation: protocol for a randomised controlled trial (2024)
Journal Article

Introduction: Purrble, a socially assistive robot, was codesigned with children to support in situ emotion regulation. Preliminary evidence has found that LGBTQ+ youth are receptive to Purrble and find it to be an acceptable intervention to assist wi... Read More about Enhancing emotion regulation with an in situ socially assistive robot among LGBTQ+ youth with self-harm ideation: protocol for a randomised controlled trial.

Language systems from lesion-symptom mapping in aphasia: A meta-analysis of voxel-based lesion mapping studies (2022)
Journal Article

Background: Aphasia is one of the most common causes of post-stroke disabilities. As the symptoms and impact of post-stroke aphasia are heterogeneous, it is important to understand how topographical lesion heterogeneity in patients with aphasia is as... Read More about Language systems from lesion-symptom mapping in aphasia: A meta-analysis of voxel-based lesion mapping studies.

Mapping brain activity of gut-brain signaling to appetite and satiety in healthy adults: A systematic review and functional neuroimaging meta-analysis (2022)
Journal Article

Understanding how neurohormonal gut-brain signaling regulates appetite and satiety is vital for the development of therapies for obesity and altered eating behavior. However, reported brain areas associated with appetite or satiety regulators show in... Read More about Mapping brain activity of gut-brain signaling to appetite and satiety in healthy adults: A systematic review and functional neuroimaging meta-analysis.

Easy to interpret Coordinate Based Meta-Analysis of neuroimaging studies: Analysis of Brain Coordinates (ABC) (2022)
Journal Article

Background: Functional MRI and voxel-based morphometry are important in neuroscience. They are technically challenging with no globally optimal analysis method, and the multiple approaches have been shown to produce different results. It is useful to... Read More about Easy to interpret Coordinate Based Meta-Analysis of neuroimaging studies: Analysis of Brain Coordinates (ABC).

Neuromelanin-MRI to Quantify and Track Nigral Depigmentation in Parkinson's Disease: A Multicenter Longitudinal Study Using Template-Based Standardized Analysis (2022)
Journal Article

Background: Clinical diagnosis and monitoring of Parkinson's disease (PD) remain challenging because of the lack of an established biomarker. Neuromelanin-magnetic resonance imaging (NM-MRI) is an emerging biomarker of nigral depigmentation indexing... Read More about Neuromelanin-MRI to Quantify and Track Nigral Depigmentation in Parkinson's Disease: A Multicenter Longitudinal Study Using Template-Based Standardized Analysis.

Dysregulated anterior insula reactivity as robust functional biomarker for chronic pain—Meta-analytic evidence from neuroimaging studies (2021)
Journal Article

Neurobiological pain models propose that chronic pain is accompanied by neurofunctional changes that mediate pain processing dysfunctions. In contrast, meta-analyses of neuroimaging studies in chronic pain conditions have not revealed convergent evid... Read More about Dysregulated anterior insula reactivity as robust functional biomarker for chronic pain—Meta-analytic evidence from neuroimaging studies.

Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study (2021)
Journal Article

Perianal Crohn’s Disease (pCD) is a common manifestation of Crohn’s Disease. Absence of reliable disease measures makes disease monitoring unreliable. Qualitative MRI has been increasingly used for diagnosing and monitoring pCD and has shown potentia... Read More about Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study.

Coordinate based meta-analysis of networks in neuroimaging studies (2019)
Journal Article
Tench, C., Tanasescu, R., Constantinescu, C., Cottam, W., & Auer, D. (2020). Coordinate based meta-analysis of networks in neuroimaging studies. NeuroImage, 205, 1-12. https://doi.org/10.1016/j.neuroimage.2019.116259

Meta-analysis of summary results from published neuroimaging studies independently testing a common hypothesis is performed using coordinate based meta-analysis (CBMA), which tests for consistent activation (in the case of functional MRI studies) of... Read More about Coordinate based meta-analysis of networks in neuroimaging studies.

Reduced Myelin Signal in Normal-appearing White Matter in Neuromyelitis Optica Measured by 7T Magnetic Resonance Imaging (2019)
Journal Article
Chou, I.-J., Tanasescu, R., Mougin, O. E., Gowland, P. A., Tench, C. R., Whitehouse, W. P., …Constantinescu, C. S. (2019). Reduced Myelin Signal in Normal-appearing White Matter in Neuromyelitis Optica Measured by 7T Magnetic Resonance Imaging. Scientific Reports, 9, Article 14378. https://doi.org/10.1038/s41598-019-50928-0

Whether the integrity of normal-appearing white matter (NAWM) is preserved in neuromyelitis optica spectrum disorders (NMOSD) is open to debate. To examine whether the tissue integrity of NAWM in NMOSD is compromised compared to that in healthy contr... Read More about Reduced Myelin Signal in Normal-appearing White Matter in Neuromyelitis Optica Measured by 7T Magnetic Resonance Imaging.

Coordinate based meta-analysis of motor functional imaging in Parkinson's: disease-specific patterns and modulation by dopamine replacement and deep brain stimulation (2019)
Journal Article
Xing, Y., Tench, C., Wongwandee, M., Schwarz, S., Bajaj, N., & Auer, D. (2020). Coordinate based meta-analysis of motor functional imaging in Parkinson's: disease-specific patterns and modulation by dopamine replacement and deep brain stimulation. Brain Imaging and Behavior, 14(4), 1263–1280. https://doi.org/10.1007/s11682-019-00061-3

Objective To investigate factors affecting the pattern of motor brain activation reported in people with Parkinson’s (PwP), aiming to differentiate disease-specific features from treatment effects. Methods A co-ordinate-based-meta-analysis (CBMA... Read More about Coordinate based meta-analysis of motor functional imaging in Parkinson's: disease-specific patterns and modulation by dopamine replacement and deep brain stimulation.

Epilepsy and associated mortality in patients with multiple sclerosis (2018)
Journal Article
Chou, I. J., Kuo, C. F., Tanasescu, R., Tench, C. R., Tiley, C. G., Constantinescu, C. S., & Whitehouse, W. P. (2018). Epilepsy and associated mortality in patients with multiple sclerosis. European Journal of Neurology, 26(2), 342-e23. https://doi.org/10.1111/ene.13821

Background and purpose: We aimed to determine the prevalence of epilepsy in patients with multiple sclerosis (MS) at diagnosis, the risk of developing epilepsy after the diagnosis of MS and the relative risk of mortality associated with epilepsy. Me... Read More about Epilepsy and associated mortality in patients with multiple sclerosis.

Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions (2017)
Journal Article
Chou, I.-J., Lim, S.-Y., Tanasescu, R., Al-Radaideh, A., Mougin, O. E., Tench, C. R., …Constantinescu, C. S. (in press). Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions. Journal of Neuroimaging, https://doi.org/10.1111/jon.12474

BACKGROUND AND PURPOSE: Fluid-attenuated inversion recovery (FLAIR) imaging at 3 Tesla (T) field strength is the most sensitive modality for detecting white matter lesions in multiple sclerosis. While 7T FLAIR is effective in detecting cortical lesio... Read More about Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions.

Automated segmentation of retinal layers from optical coherence tomography images using geodesic distance (2017)
Journal Article
Duan, J., Tench, C., Gottlob, I., Proudlock, F., & Bai, L. (2017). Automated segmentation of retinal layers from optical coherence tomography images using geodesic distance. Pattern Recognition, 72, 158-175. https://doi.org/10.1016/j.patcog.2017.07.004

Optical coherence tomography (OCT) is a noninvasive imaging technique that can produce images of the eye at the microscopic level. OCT image segmentation to detect retinal layer boundaries is a fundamental procedure for diagnosing and monitoring the... Read More about Automated segmentation of retinal layers from optical coherence tomography images using geodesic distance.

Coordinate based random effect size meta-analysis of neuroimaging studies (2017)
Journal Article
Tench, C. R., Tanasescu, R., Constantinescu, C. S., Auer, D. P., & Cottam, W. J. (in press). Coordinate based random effect size meta-analysis of neuroimaging studies. NeuroImage, 153, https://doi.org/10.1016/j.neuroimage.2017.04.002

Low power in neuroimaging studies can make them difficult to interpret, and Coordinate based meta-analysis (CBMA) may go some way to mitigating this issue. CBMA has been used in many analyses to detect where published functional MRI or voxel-based mo... Read More about Coordinate based random effect size meta-analysis of neuroimaging studies.

Multiple sclerosis course and clinical outcomes in patients with comorbid asthma: a survey study (2015)
Journal Article
Manouchehrinia, A., Edwards, L. J., Roshanisefat, H., Tench, C. R., & Constantinescu, C. S. (2015). Multiple sclerosis course and clinical outcomes in patients with comorbid asthma: a survey study. BMJ Open, 5(5), 1-7. https://doi.org/10.1136/bmjopen-2015-007806

Objective: To determine if comorbid asthma is associated with accumulation of multiple sclerosis (MS)-related impairment and disability. Method: We sent a comprehensive questionnaire to a cohort of patients with MS and examined the association bet... Read More about Multiple sclerosis course and clinical outcomes in patients with comorbid asthma: a survey study.