Skip to main content

Research Repository

Advanced Search

Coordinate based meta-analysis of networks in neuroimaging studies

Tench, C.R.; Tanasescu, Radu; Constantinescu, C.S.; Cottam, W.J.; Auer, D.P.

Coordinate based meta-analysis of networks in neuroimaging studies Thumbnail


Authors

Radu Tanasescu

C.S. Constantinescu

W.J. Cottam

DOROTHEE AUER dorothee.auer@nottingham.ac.uk
Professor of Neuroimaging



Contributors

Abstract

Meta-analysis of summary results from published neuroimaging studies independently testing a common hypothesis is performed using coordinate based meta-analysis (CBMA), which tests for consistent activation (in the case of functional MRI studies) of the same anatomical regions. Using just the reported coordinates it is also possible to meta-analyse coactivated regions to reveal a network-like structure of coordinate clusters (network nodes) distributed at the coactivated locations and a measure of the coactivation strength (network edges), which is determined by the presence/absence of reported activation.

Here a new coordinate-based method to estimate a network of coactivations is detailed, which utilises the Z score accompanying each reported. Coordinate based meta-analysis of networks (CBMAN) assumes that if the activation pattern reported by independent studies is truly consistent, then the relative magnitude of these Z scores might also be consistent. It is hypothesised that this is detectable as Z score covariance between coactivated regions provided the within study variances are small. Advantages of using the Z scores instead of coordinates to measure coactivation strength are that censoring by the significance thresholds can be considered, and that using a continuous measure rather than a dichotomous one can increase statistical power.

CBMAN uses maximum likelihood estimation to fit multivariate normal distributions to the standardised Z scores, and the covariances are considered as edges of a network of coactivated clusters (nodes). Here it is validated by numerical simulation and demonstrated on real data used previously to demonstrate CBMA. Software to perform CBMAN is freely available.

Citation

Tench, C., Tanasescu, R., Constantinescu, C., Cottam, W., & Auer, D. (2020). Coordinate based meta-analysis of networks in neuroimaging studies. NeuroImage, 205, 1-12. https://doi.org/10.1016/j.neuroimage.2019.116259

Journal Article Type Article
Acceptance Date Oct 7, 2019
Online Publication Date Oct 15, 2019
Publication Date Jan 15, 2020
Deposit Date Oct 16, 2019
Publicly Available Date Mar 29, 2024
Journal NeuroImage
Print ISSN 1053-8119
Electronic ISSN 1095-9572
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 205
Article Number 116259
Pages 1-12
DOI https://doi.org/10.1016/j.neuroimage.2019.116259
Keywords Cognitive Neuroscience; Neurology
Public URL https://nottingham-repository.worktribe.com/output/2848545
Publisher URL https://www.sciencedirect.com/science/article/pii/S105381191930850X?via%3Dihub

Files




You might also like



Downloadable Citations