All Outputs (61)

Therapist-supported online remote behavioural intervention for tics in children and adolescents in England (ORBIT): a multicentre, parallel group, single-blind, randomised controlled trial (2021)
Journal Article
Hollis, C., Hall, C. L., Jones, R., Marston, L., Novere, M. L., Hunter, R., …Murray, E. (2021). Therapist-supported online remote behavioural intervention for tics in children and adolescents in England (ORBIT): a multicentre, parallel group, single-blind, randomised controlled trial. Lancet Psychiatry, 8(10), 871-882. https://doi.org/10.1016/S2215-0366%2821%2900235-2

Background: Exposure and Response Prevention (ERP) is a form of behavioural therapy for tics; however, its effectiveness remains uncertain. We aimed to evaluate the effectiveness of internet-delivered, therapist-supported, and parent-assisted ERP for... Read More about Therapist-supported online remote behavioural intervention for tics in children and adolescents in England (ORBIT): a multicentre, parallel group, single-blind, randomised controlled trial.

PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression (2021)
Preprint / Working Paper
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Hollis, C., Hippisley-Cox, J., & Coupland, C. PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression

This protocol describes a cohort study comparing the risks of mortality and serious self-harm (suicide or near-fatal deliberate self-harm) between adults with depression prescribed mirtazapine, a selective serotonin reuptake inhibitor (SSRI), amitrip... Read More about PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression.

The implementation of telehealth to assess, monitor and treat neurodevelopmental disorders: a systematic review (2021)
Journal Article
Valentine, A. Z., Hall, S. S., Young, E., Brown, B. J., Groom, M. J., Hollis, C., & Hall, C. L. (2021). The implementation of telehealth to assess, monitor and treat neurodevelopmental disorders: a systematic review. Journal of Medical Internet Research, 23(1), Article e22619. https://doi.org/10.2196/22619

Background: In response to COVID-19 there is increasing momentum behind the development and delivery of telehealth. To assess the anticipated exponential growth in telehealth it is important we accurately capture how telehealth was used in specific f... Read More about The implementation of telehealth to assess, monitor and treat neurodevelopmental disorders: a systematic review.

Opportunities and challenges of delivering digital clinical trials: lessons learned from a randomised controlled trial of an online behavioural intervention for children and young people (2020)
Journal Article
Hall, C. L., Sanderson, C., Brown, B. J., Andrén, P., Bennett, S., Chamberlain, L. R., …Murray, E. (2020). Opportunities and challenges of delivering digital clinical trials: lessons learned from a randomised controlled trial of an online behavioural intervention for children and young people. Trials, 21(1), Article 1011. https://doi.org/10.1186/s13063-020-04902-1

Background: Despite being the gold standard of research to determine effectiveness, randomised controlled trials (RCTs) often struggle with participant recruitment, engagement and retention. These issues may be exacerbated when recruiting vulnerable... Read More about Opportunities and challenges of delivering digital clinical trials: lessons learned from a randomised controlled trial of an online behavioural intervention for children and young people.

The transition from children’s services to adult services for young people with attention deficit hyperactivity disorder: the CATCh-uS mixed-methods study (2020)
Journal Article
Janssens, A., Eke, H., Price, A., Newlove-Delgado, T., Blake, S., Ani, C., …Ford, T. (2020). The transition from children’s services to adult services for young people with attention deficit hyperactivity disorder: the CATCh-uS mixed-methods study. Health Services and Delivery Research, 8(42), 1-154. https://doi.org/10.3310/hsdr08420

Informing the Development of a Digital Health Platform Through Universal Points of Care: Qualitative Survey Study (2020)
Journal Article
Craven, M. P., Andrews, J., Lang, A. R., Simblett, S. K., Bruce, S., Thorpe, S., …The RADAR-CNS Consortium. (2020). Informing the Development of a Digital Health Platform Through Universal Points of Care: Qualitative Survey Study. JMIR Formative Research, 4(11), Article e22756. https://doi.org/10.2196/22756

Background: Epilepsy, multiple sclerosis (MS), and depression are chronic conditions where technology holds potential in clinical monitoring and self-management. Over 5 years, the Remote Assessment of Disease and Relapse-Central Nervous System (RADAR... Read More about Informing the Development of a Digital Health Platform Through Universal Points of Care: Qualitative Survey Study.

Therapist supported online interventions for children and young people with tic disorders: lessons learned from a randomized controlled trial and considerations for future practice (2020)
Journal Article
Chamberlain, L. R., Hall, C., Andrén, P., Davies, E. B., Kilgariff, J., Kouzoupi, N., …Hollis, C. (2020). Therapist supported online interventions for children and young people with tic disorders: lessons learned from a randomized controlled trial and considerations for future practice. JMIR Mental Health, 7(10), Article e19600. https://doi.org/10.2196/19600

Preventive digital mental health interventions for children and young people: a review of the design and reporting of research (2020)
Journal Article
Bergin, A. D., Vallejos, E. P., Davies, E. B., Daley, D., Ford, T., Harold, G., …Hollis, C. (2020). Preventive digital mental health interventions for children and young people: a review of the design and reporting of research. npj Digital Medicine, 3(1), Article 133. https://doi.org/10.1038/s41746-020-00339-7

Digital health interventions (DHIs) have frequently been highlighted as one way to respond to increasing levels of mental health problems in children and young people. Whilst many are developed to address existing mental health problems, there is als... Read More about Preventive digital mental health interventions for children and young people: a review of the design and reporting of research.

Health Care Professionals’ Views on Using Remote Measurement Technology in Managing Central Nervous System Disorders: Qualitative Interview Study (2020)
Journal Article
Andrews, J. A., Craven, M. P., Jamnadas-Khoda, J., Lang, A. R., Morriss, R., Hollis, C., & The RADAR-CNS Consortium. (2020). Health Care Professionals’ Views on Using Remote Measurement Technology in Managing Central Nervous System Disorders: Qualitative Interview Study. Journal of Medical Internet Research, 22(7), Article e17414. https://doi.org/10.2196/17414

Background: Remote measurement technologies (RMT) can be used to collect data on a variety of bio-behavioral variables, which may improve the care of patients with central nervous system disorders. Although various studies have explored their potenti... Read More about Health Care Professionals’ Views on Using Remote Measurement Technology in Managing Central Nervous System Disorders: Qualitative Interview Study.

Antipsychotic medication versus psychological intervention versus a combination of both in adolescents with first-episode psychosis (MAPS): a multicentre, three-arm, randomised controlled pilot and feasibility study (2020)
Journal Article
Morrison, A. P., Pyle, M., Maughan, D., Johns, L., Freeman, D., Broome, M. R., …James, A. (2020). Antipsychotic medication versus psychological intervention versus a combination of both in adolescents with first-episode psychosis (MAPS): a multicentre, three-arm, randomised controlled pilot and feasibility study. Lancet Psychiatry, 7(9), 788-800. https://doi.org/10.1016/S2215-0366%2820%2930248-0

Background: Evidence for the effectiveness of treatments in early-onset psychosis is sparse. Current guidance for the treatment of early-onset psychosis is mostly extrapolated from trials in adult populations. The UK National Institute for Health and... Read More about Antipsychotic medication versus psychological intervention versus a combination of both in adolescents with first-episode psychosis (MAPS): a multicentre, three-arm, randomised controlled pilot and feasibility study.

Incidence and prevalence of primary care antidepressant prescribing in children and young people in England, 1998-2017: A population-based cohort study (2020)
Journal Article
Jack, R. H., Hollis, C., Coupland, C., Morriss, R., Knaggs, R. D., Butler, D., …Hippisley-Cox, J. (2020). Incidence and prevalence of primary care antidepressant prescribing in children and young people in England, 1998-2017: A population-based cohort study. PLoS Medicine, 17(7), Article e1003215. https://doi.org/10.1371/journal.pmed.1003215

BACKGROUND: The use of antidepressants in children and adolescents remains controversial. We examined trends over time and variation in antidepressant prescribing in children and young people in England and whether the drugs prescribed reflected UK l... Read More about Incidence and prevalence of primary care antidepressant prescribing in children and young people in England, 1998-2017: A population-based cohort study.

A systematic review evaluating the implementation of technologies to assess, monitor and treat neurodevelopmental disorders: A map of the current evidence (2020)
Journal Article
Valentine, A. Z., Brown, B. J., Groom, M. J., Young, E., Hollis, C., & Hall, C. L. (2020). A systematic review evaluating the implementation of technologies to assess, monitor and treat neurodevelopmental disorders: A map of the current evidence. Clinical Psychology Review, 80, 101870. https://doi.org/10.1016/j.cpr.2020.101870

Technology-based interventions provide an attractive option for improving service provision for neurodevelopmental disorders (NDD), for example, widening access to interventions, objective assessment, and monitoring; however, it is unclear whether th... Read More about A systematic review evaluating the implementation of technologies to assess, monitor and treat neurodevelopmental disorders: A map of the current evidence.

Healthcare professional views of implementing remote measurement technology in central nervous system disorders: A qualitative interview study (Preprint) (2019)
Other
Andrews, J., Craven, M. P., Jamnadas-Khoda, J., Lang, A. R., Morriss, R., & Hollis, C. (in press). Healthcare professional views of implementing remote measurement technology in central nervous system disorders: A qualitative interview study (Preprint)

Background: Remote measurement technologies (RMTs) can be used to collect data on a variety of bio-behavioural variables, which may benefit the care of people with central nervous system disorders. While various studies have explored their potential... Read More about Healthcare professional views of implementing remote measurement technology in central nervous system disorders: A qualitative interview study (Preprint).

Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets (2019)
Journal Article
Jack, R. H., Hollis, C., Coupland, C., Morriss, R., Knaggs, R. D., Cipriani, A., …Hippisley-Cox, J. (2019). Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets. Evidence-Based Mental Health, 22(3), 129-133. https://doi.org/10.1136/ebmental-2019-300097

Introduction Increasing numbers of children and young people (CYP) are receiving prescriptions for antidepressants. This is the protocol of a study aiming to describe the trends and variation in antidepressant prescriptions in CYP in England, and t... Read More about Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets.

Methylphenidate and the risk of psychosis in adolescents and young adults: a population-based cohort study (2019)
Journal Article
Hollis, C., Chen, Q., Chang, Z., Quinn, P. D., Viktorin, A., Lichtenstein, P., …Larsson, H. (2019). Methylphenidate and the risk of psychosis in adolescents and young adults: a population-based cohort study. Lancet Psychiatry, 6(8), 651-658. https://doi.org/10.1016/s2215-0366%2819%2930189-0

Background: There is a clinical concern that prescribing methylphenidate, the most common pharmacological treatment for attention-deficit hyperactivity disorder (ADHD), might increase the risk of psychotic events, particularly in young people with a... Read More about Methylphenidate and the risk of psychosis in adolescents and young adults: a population-based cohort study.

A Feasibility Trial of Power Up: Smartphone App to Support Patient Activation and Shared Decision Making for Mental Health in Young People (2019)
Journal Article
Edbrooke-Childs, J., Edridge, C., Averill, P., Delane, L., Hollis, C., Carven, M., …Wolpert, M. (2019). A Feasibility Trial of Power Up: Smartphone App to Support Patient Activation and Shared Decision Making for Mental Health in Young People. JMIR mHealth and uHealth, 7(6), Article e11677. https://doi.org/10.2196/11677

Background: Digital tools have the potential to support patient activation and shared decision making in the face of increasing levels of mental health problems in young people. There is a need for feasibility trials of digital interventions to deter... Read More about A Feasibility Trial of Power Up: Smartphone App to Support Patient Activation and Shared Decision Making for Mental Health in Young People.

Towards a consensus around standards for smartphone apps and digital mental health (2019)
Journal Article
John Torous, J., Anderson, G., Bertagnoli, A., Christensen, H., Cuijpers, P., Firth, J., …Arean, P. A. (2019). Towards a consensus around standards for smartphone apps and digital mental health. World Psychiatry, 18(1), 97-98. https://doi.org/10.1002/wps.20592

Mental disorders impact one in four people worldwide, yet access to care is challenging for those who suffer from them1. Mental health apps offer the potential to overcome access barriers for the nearly three billion people projected to own a smartph... Read More about Towards a consensus around standards for smartphone apps and digital mental health.

The use of the QbTest in clinical practice (2018)
Journal Article
Hall, C. L., & Hollis, C. (2018). The use of the QbTest in clinical practice. ADHD in Practice, 10(3), 49-52

Diagnosing and managing attention deficit and hyperactivity disorder (ADHD) typically relies on subjective measures. When assessing children and young people for ADHD, the clinician gathers information from parents and teachers and uses these various... Read More about The use of the QbTest in clinical practice.

Effects of long-term methylphenidate use on growth and blood pressure: results of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) (2018)
Journal Article
McCarthy, S., Neubert, A., Man, K. K. C., Banaschewski, T., Buitelaar, J., Carucci, S., …Wong, I. C. K. (2018). Effects of long-term methylphenidate use on growth and blood pressure: results of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS). BMC Psychiatry, 18(1), Article 327. https://doi.org/10.1186/s12888-018-1884-7

© 2018 The Author(s). Background: Concerns have been raised over the safety of methylphenidate (MPH), with regard to adverse effects on growth and blood pressure. Our study investigates whether, and to what extent, methylphenidate use in boys with AD... Read More about Effects of long-term methylphenidate use on growth and blood pressure: results of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS).

Cognitive predictors of parent-rated inattention in very preterm children: The role of working memory and processing speed (2018)
Journal Article
Retzler, J., Johnson, S., Groom, M., Hollis, C., Budge, H., & Cragg, L. (2019). Cognitive predictors of parent-rated inattention in very preterm children: The role of working memory and processing speed. Child Neuropsychology, 25(5), 617-635. https://doi.org/10.1080/09297049.2018.1510908

Background: Inattention is one of the most common neurobehavioural problems following very preterm birth. Attention problems can persist into adulthood and are associated with negative socio-emotional and educational outcomes. This study aimed to det... Read More about Cognitive predictors of parent-rated inattention in very preterm children: The role of working memory and processing speed.