All Outputs (65)

Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease (2016)
Journal Article
John, M., McKeever, T. M., Haddad, M. A., Hall, I. P., Sayers, I., Cockcroft, J. R., & Bolton, C. E. (2016). Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease. Chronic Respiratory Disease, 13(3), https://doi.org/10.1177/1479972316636995

With the increased cardiovascular (CV) morbidity and mortality in subjects with chronic obstructive pulmonary disease (COPD), there is a priority to identify those patients at increased risk of cardiovascular disease. Stable patients with COPD (n = 1... Read More about Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease.

Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12 (2016)
Journal Article
Jackson, V. E., Ntalla, I., Sayers, I., Morris, R., Whincup, P., Casas, J.-P., Amuzu, A., Choi, M., Dale, C., Kumari, M., Engmann, J., Kalsheker, N., Chappell, S., Guetta-Baranes, T., McKeever, T. M., Palmer, C. N., Tavendale, R., Holloway, J. W., Sayer, A. A., Dennison, E. M., …Wain, L. V. (in press). Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12. Thorax, 71(6), https://doi.org/10.1136/thoraxjnl-2015-207876

Background

Several regions of the genome have shown to be associated with COPD in genome-wide association studies of common variants.

Objective

To determine rare and potentially functional single nucleotide polymorphisms (SNPs) associated... Read More about Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12.

Pulmonary arterial response to hypoxia in survivors of chronic lung disease of prematurity (2015)
Journal Article
Poon, C. Y., Watkins, W. J., Evans, C. J., Tsai-Goodman, B., BOLTON, C., Cockcroft, J. R., Wise, R. G., & Kotecha, S. (2015). Pulmonary arterial response to hypoxia in survivors of chronic lung disease of prematurity. Archives of Disease in Childhood. Fetal and Neonatal Edition, 101(4), F309-F313. https://doi.org/10.1136/archdischild-2015-309015

Background: It is unclear whether increased pulmonary arterial (PA) reactivity to hypoxia observed in preterm infants who develop chronic lung disease of prematurity (CLD) persists into childhood.

Aim: We assessed and compared PA pulse wave veloci... Read More about Pulmonary arterial response to hypoxia in survivors of chronic lung disease of prematurity.

Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial. (2015)
Journal Article
John, M., Cockcroft, J. R., McKeever, T. M., Coward, W. R., Shale, D. J., Johnson, S. R., Thornton, J., Harrison, T. W., Knox, A. J., & Bolton, C. E. (2015). Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial. International Journal of Chronic Obstructive Pulmonary Disease, 10(1), https://doi.org/10.2147/COPD.S76061

BACKGROUND:

There is excess cardiovascular mortality in patients with chronic obstructive pulmonary disease. Aortic stiffness, an independent predictor of cardiovascular risk, and systemic and airway inflammation are increased in patients with the... Read More about Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial..

Target renal damage: the microvascular associations of increased aortic stiffness in patients with COPD (2013)
Journal Article
John, M., Hussain, S., Prayle, A., Simms, R., Cockroft, J. R., & Bolton, C. E. (2013). Target renal damage: the microvascular associations of increased aortic stiffness in patients with COPD. Respiratory Research, 14(31), https://doi.org/10.1186/1465-9921-14-31

Background
Although renal impairment has been described in COPD, there is opportunity to evaluate further to determine nature and consider optimal management. Increased aortic stiffness, as seen in COPD, leads to reduced buffering of pulsatile flow.... Read More about Target renal damage: the microvascular associations of increased aortic stiffness in patients with COPD.