The P body protein LSm1 contributes to stimulation of hepatitis C virus translation, but not replication, by microRNA-122

Roberts, Ashley P.E.; Doidge, Rachel; Tarr, Alexander W.; Jopling, Catherine L.

doi:10.1093/nar/gkt941

All Outputs (5)

The circadian clock components BMAL1 and REV-ERB? regulate flavivirus replication (2019)
Journal Article

© 2019, The Author(s). The circadian clock regulates immune responses to microbes and affects pathogen replication, but the underlying molecular mechanisms are not well understood. Here we demonstrate that the circadian components BMAL1 and REV-ERBα... Read More about The circadian clock components BMAL1 and REV-ERB? regulate flavivirus replication.

Eukaryotic translation initiation factor 4All contributes to microRNA-122 regulation of hepatitis C virus replication (2018)
Journal Article

Hepatitis C virus (HCV) is a positive sense RNA virus that persistently infects human liver, leading to cirrhosis and hepatocellular carcinoma. HCV replication requires the liver-specific microRNA-122 (miR-122). In contrast to canonical miRNA-mediat... Read More about Eukaryotic translation initiation factor 4All contributes to microRNA-122 regulation of hepatitis C virus replication.

Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs (2015)
Journal Article

MicroRNA (miRNA) play a major role in the post-transcriptional regulation of gene expression. Mammalian miRNA biogenesis begins with co-transcriptional cleavage of RNA polymerase II (Pol II) transcripts by the Microprocessor complex. While most miRNA... Read More about Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs.

Stop that nonsense! (2014)
Journal Article

Copyright © 2014, Jopling. Cells can avoid the effects of so-called 'nonsense' mutations by several methods, including a newly discovered mechanism driven by microRNA molecules.

The P body protein LSm1 contributes to stimulation of hepatitis C virus translation, but not replication, by microRNA-122 (2013)
Journal Article

The P body protein LSm1 stimulates translation and replication of hepatitis C virus (HCV). As the liver-specific microRNA-122 (miR-122) is required for HCV replication and is associated with P bodies, we investigated whether regulation of HCV by LSm1... Read More about The P body protein LSm1 contributes to stimulation of hepatitis C virus translation, but not replication, by microRNA-122.