Re: Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case Control Study
(2019)
Journal Article
All Outputs (131)
Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets (2019)
Journal Article
Introduction Increasing numbers of children and young people (CYP) are receiving prescriptions for antidepressants. This is the protocol of a study aiming to describe the trends and variation in antidepressant prescriptions in CYP in England, and t... Read More about Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets.
Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study (2019)
Journal Article
IMPORTANCE Anticholinergic medicines have short-term cognitive adverse effects, but it is uncertain whether long-term use of these drugs is associated with an increased risk of dementia. OBJECTIVE To assess associations between anticholinergic dr... Read More about Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study.
Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases (2019)
Journal Article
Objectives: To assess risk of venous thromboembolism associated with different types of hormone replacement therapy. Design: Two nested case-control studies. Setting: UK general practices contributing to QResearch or Clinical Practice Research... Read More about Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases.
Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care (2018)
Journal Article
Objective: To investigate the associations between direct oral anticoagulants (DOACs) and risks of bleeding, ischaemic stroke, venous thromboembolism, and all cause mortality compared with warfarin. Design: Prospective open cohort study. Settin... Read More about Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care.
Early risk factors for depression, anxiety and post-traumatic distress after hospital admission for unintentional injury: multicentre cohort study (2018)
Journal Article
Objective: To quantify psychological morbidity and identify baseline factors associated with depression, anxiety and post-traumatic distress symptoms up to 12 months post-injury. Methods: Multicentre cohort study of 668 adults, aged 16 to 70,... Read More about Early risk factors for depression, anxiety and post-traumatic distress after hospital admission for unintentional injury: multicentre cohort study.
Risk of bleeding with direct oral anticoagulants versus warfarin: cohort studies using primary care datasets (2018)
Journal Article
Background: There is limited evidence on the safety of direct oral anticoagulants (DOACs) in real world settings. Aim: To investigate risks of bleeding and all-cause mortality in DOACs compared to warfarin. Method: Prospective cohorts of incide... Read More about Risk of bleeding with direct oral anticoagulants versus warfarin: cohort studies using primary care datasets.
Antidepressant use and risk of adverse outcomes in people aged 20–64 years: cohort study using a primary care database (2018)
Journal Article
© 2018 The Author(s). Background: Antidepressants are one of the most commonly prescribed medications in young and middle-aged adults, but there is relatively little information on their safety across a range of adverse outcomes in this age group. Th... Read More about Antidepressant use and risk of adverse outcomes in people aged 20–64 years: cohort study using a primary care database.
PHysical activity Implementation Study In Community-dwelling AduLts (PHISICAL): study protocol (2018)
Journal Article
Background: Falls in older people are a leading causes of unintentional injury. Due to an ageing population, injuries are likely to increase unless more is done to reduce older people’s falls risk. In clinical trials, the Falls Management Exercise (F... Read More about PHysical activity Implementation Study In Community-dwelling AduLts (PHISICAL): study protocol.
Harnessing the power of intelligent machines to enhance primary care (2017)
Journal Article
Alcohol Misuse and Injury Outcomes in Young People Aged 10–24 (2017)
Journal Article
Purpose: The burden of alcohol-attributable disease is a global problem. Young people often present to emergency health-care services with alcohol intoxication but little is known about how best to intervene at that point to improve future health out... Read More about Alcohol Misuse and Injury Outcomes in Young People Aged 10–24.
Development and validation of QDiabetes-2018 risk prediction algorithm to estimate future risk of type 2 diabetes: cohort study (2017)
Journal Article
Objectives: To derive and validate updated QDiabetes-2018 prediction algorithms to estimate the 10 year risk of type 2 diabetes in men and women, taking account of potential new risk factors, and to compare their performance with current approaches.... Read More about Development and validation of QDiabetes-2018 risk prediction algorithm to estimate future risk of type 2 diabetes: cohort study.
Development and validation of QMortality risk prediction algorithm to estimate short term risk of death and assess frailty: cohort study (2017)
Journal Article
Objectives: To derive and validate a risk prediction equation to estimate the short term risk of death, and to develop a classification method for frailty based on risk of death and risk of unplanned hospital admission. Design: Prospective open... Read More about Development and validation of QMortality risk prediction algorithm to estimate short term risk of death and assess frailty: cohort study.
Keeping children safe: a multicentre programme of research to increase the evidence base for preventing unintentional injuries in the home in the under-fives (2017)
Journal Article
Background: Unintentional injuries among 0- to 4-year-olds are a major public health problem incurring substantial NHS, individual and societal costs. However, evidence on the effectiveness and cost-effectiveness of preventative interventions is lack... Read More about Keeping children safe: a multicentre programme of research to increase the evidence base for preventing unintentional injuries in the home in the under-fives.
Psychological morbidity and return to work after injury: multicentre cohort study (2017)
Journal Article
Background: The benefits of work for physical, psychological and financial wellbeing are well documented. Return to work (RTW) after unintentional injury is often delayed, and psychological morbidity may contribute to this delay. The impact of psycho... Read More about Psychological morbidity and return to work after injury: multicentre cohort study.
Development and validation of risk prediction equations to estimate survival in patients with colorectal cancer: cohort study (2017)
Journal Article
Objective: To develop and externally validate risk prediction equations to estimate absolute and conditional survival in patients with colorectal cancer. Design: Cohort study. Setting: General practices in England providing data for the QResea... Read More about Development and validation of risk prediction equations to estimate survival in patients with colorectal cancer: cohort study.
Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study (2017)
Journal Article
Objectives: To develop and validate updated QRISK3 prediction algorithms to estimate the 10 year risk of cardiovascular disease in women and men accounting for potential new risk factors. Design: Prospective open cohort study. Setting: General... Read More about Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study.
Concerns on 'clinical features of bowel disease paper in patients (eLetter) (2017)
Journal Article