All Outputs (4)

An Integrated Pipeline for Combining in vitro Data and Mathematical Models Using a Bayesian Parameter Inference Approach to Characterize Spatio-temporal Chemokine Gradient Formation (2019)
Journal Article
Kalogiros, D. I., Russell, M., Bonneuil, W., Frattolin, J., Watson, D., Moore Jr, J. E., …Brook, B. S. (2019). An Integrated Pipeline for Combining in vitro Data and Mathematical Models Using a Bayesian Parameter Inference Approach to Characterize Spatio-temporal Chemokine Gradient Formation. Frontiers in Immunology, 10, Article 1986. https://doi.org/10.3389/fimmu.2019.01986

All protective and pathogenic immune and inflammatory responses rely heavily on leukocyte migration and localization. Chemokines are secreted chemoattractants that orchestrate the positioning and migration of leukocytes through concentration gradient... Read More about An Integrated Pipeline for Combining in vitro Data and Mathematical Models Using a Bayesian Parameter Inference Approach to Characterize Spatio-temporal Chemokine Gradient Formation.

A multiphase multiscale model for nutrient limited tissue growth, Part II: A simplified description (2019)
Journal Article
Holden, E., Chapman, S., Brook, B., & O'Dea, R. (2019). A multiphase multiscale model for nutrient limited tissue growth, Part II: A simplified description. ANZIAM Journal, 61(4), 368-381. https://doi.org/10.1017/S1446181119000130

In this paper, we revisit and extend our recent work (Holden et al. (2018) A multiphase multiscale model for nutrient limited tissue growth, The ANZIAM Journal, 59(4), 499-532), that considers the derivation of an effective macroscale description sui... Read More about A multiphase multiscale model for nutrient limited tissue growth, Part II: A simplified description.

Cellular uptake and efflux of palbociclib in vitro in single cell and spheroid models (2019)
Journal Article
Jove, M., Spencer, J. A., Hubbard, M. E., Holden, E. C., O'Dea, R. D., Brook, B. S., …Twelves, C. J. (2019). Cellular uptake and efflux of palbociclib in vitro in single cell and spheroid models. Journal of Pharmacology and Experimental Therapeutics, 370(2), 242-251. https://doi.org/10.1124/jpet.119.256693

Adequate drug distribution through tumors is essential for treatment to be effective. Palbociclib is a cyclin-dependent kinase 4/6 inhibitor approved for use in patients with hormone receptor positive, human epidermal growth factor receptor 2 negativ... Read More about Cellular uptake and efflux of palbociclib in vitro in single cell and spheroid models.

Small airway hyperresponsiveness in COPD: relationship between structure and function in lung slices (2019)
Journal Article
Maarsingh, H., Bidan, C. M., Brook, B. S., Zuidhof, A. B., Elzinga, C. R., Smit, M., …Meurs, H. (2019). Small airway hyperresponsiveness in COPD: relationship between structure and function in lung slices. AJP - Lung Cellular and Molecular Physiology, 316(3), L537-L546. https://doi.org/10.1152/ajplung.00325.2018

The direct relationship between pulmonary structural changes and airway hyperresponsiveness (AHR) in chronic obstructive pulmonary disease (COPD) is unclear. We investigated AHR in relation to airway and parenchymal structural changes in a guinea pig... Read More about Small airway hyperresponsiveness in COPD: relationship between structure and function in lung slices.