All Outputs (15)

A conserved trypanosomatid differentiation regulator controls substrate attachment and morphological development in Trypanosoma congolense (2024)
Journal Article

Trypanosomatid parasites undergo developmental regulation to adapt to the different environments encountered during their life cycle. In Trypanosoma brucei, a genome wide selectional screen previously identified a regulator of the protein family ESAG... Read More about A conserved trypanosomatid differentiation regulator controls substrate attachment and morphological development in Trypanosoma congolense.

A synthetic ancestral kinesin-13 depolymerizes microtubules faster than any natural depolymerizing kinesin (2022)
Journal Article

The activity of a kinesin is largely determined by the approximately 350 residue motor domain, and this region alone is sufficient to classify a kinesin as a member of a particular family. The kinesin-13 family are a group of microtubule depolymerizi... Read More about A synthetic ancestral kinesin-13 depolymerizes microtubules faster than any natural depolymerizing kinesin.

Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition (2021)
Journal Article

Animal African Trypanosomiasis (AAT) is a debilitating livestock disease prevalent across sub-Saharan Africa, a main cause of which is the protozoan parasite Trypanosoma congolense. In comparison to the well-studied T. brucei, there is a major paucit... Read More about Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition.

Trypanosome KKIP1 Dynamically Links the Inner Kinetochore to a Kinetoplastid Outer Kinetochore Complex (2021)
Journal Article

Kinetochores perform an essential role in eukaryotes, coupling chromosomes to the mitotic spindle. In model organisms they are composed of a centromere-proximal inner kinetochore and an outer kinetochore network that binds to microtubules. In spite o... Read More about Trypanosome KKIP1 Dynamically Links the Inner Kinetochore to a Kinetoplastid Outer Kinetochore Complex.

TbSAP is a novel chromatin protein repressing metacyclic variant surface glycoprotein expression sites in bloodstream form Trypanosoma brucei (2021)
Journal Article

The African trypanosome Trypanosoma brucei is a unicellular eukaryote, which relies on a protective variant surface glycoprotein (VSG) coat for survival in the mammalian host. A single trypanosome has >2000 VSG genes and pseudogenes of which only one... Read More about TbSAP is a novel chromatin protein repressing metacyclic variant surface glycoprotein expression sites in bloodstream form Trypanosoma brucei.

Reliable, scalable functional genetics in bloodstream-form Trypanosoma congolense in vitro and in vivo (2021)
Journal Article

Copyright: © 2021 Awuah-Mensah et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author a... Read More about Reliable, scalable functional genetics in bloodstream-form Trypanosoma congolense in vitro and in vivo.

Comparative genomic analysis of the ‘pseudofungus’ Hyphochytrium catenoides (2018)
Journal Article

Trypanosome outer kinetochore proteins suggest conservation of chromosome segregation machinery across eukaryotes (2016)
Journal Article

Kinetochores are multiprotein complexes that couple eukaryotic chromosomes to the mitotic spindle to ensure proper segregation. The model for kinetochore assembly is conserved between humans and yeast, and homologues of several components are widely... Read More about Trypanosome outer kinetochore proteins suggest conservation of chromosome segregation machinery across eukaryotes.

The family-specific ?4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition (2016)
Journal Article

Kinesins that influence the dynamics of microtubule growth and shrinkage require the ability to distinguish between the microtubule end and the microtubule lattice. The microtubule depolymerizing kinesin MCAK has been shown to specifically recognize... Read More about The family-specific ?4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition.

Plasmodium P-type cyclin CYC3 modulates endomitotic growth during oocyst development in mosquitoes (2015)
Journal Article

Cell-cycle progression and cell division in eukaryotes are governed in part by the cyclin family and their regulation of cyclin-dependent kinases (CDKs). Cyclins are very well characterised in model systems such as yeast and human cells, but surprisi... Read More about Plasmodium P-type cyclin CYC3 modulates endomitotic growth during oocyst development in mosquitoes.

Identification of the ISWI chromatin remodeling complex of the early branching Eukaryote Trypanosoma brucei (2015)
Journal Article

ISWI chromatin remodelers are highly conserved in eukaryotes and are important for the assembly and spacing of nucleosomes, thereby controlling transcription initiation and elongation. ISWI is typically associated with different subunits, forming sp... Read More about Identification of the ISWI chromatin remodeling complex of the early branching Eukaryote Trypanosoma brucei.

Architecture of a host–parasite interface: complex targeting mechanisms revealed through proteomics (2015)
Journal Article

Surface membrane organization and composition is key to cellular function, and membrane proteins serve many essential roles in endocytosis, secretion, and cell recognition. The surface of parasitic organisms, however, is a double-edged sword; this is... Read More about Architecture of a host–parasite interface: complex targeting mechanisms revealed through proteomics.

Genome-wide Functional Analysis of Plasmodium Protein Phosphatases Reveals Key Regulators of Parasite Development and Differentiation (2014)
Journal Article

Reversible protein phosphorylation regulated by kinases and phosphatases controls many cellular processes. Although essential functions for the malaria parasite kinome have been reported, the roles of most protein phosphatases (PPs) during Plasmodium... Read More about Genome-wide Functional Analysis of Plasmodium Protein Phosphatases Reveals Key Regulators of Parasite Development and Differentiation.

A SAS-6-like protein suggests that the Toxoplasma conoid complex evolved from flagellar components (2013)
Journal Article

SAS-6 is required for centriole biogenesis in diverse eukaryotes. Here, we describe a novel family of SAS-6-like (SAS6L) proteins that share an N-terminal domain with SAS-6 but lack coiled-coil tails. SAS6L proteins are found in a subset of eukaryote... Read More about A SAS-6-like protein suggests that the Toxoplasma conoid complex evolved from flagellar components.

A unique protein phosphatase with kelch-like domains (PPKL) in plasmodium modulates ookinete differentiation, motility and invasion (2012)
Journal Article

Protein phosphorylation and dephosphorylation (catalysed by kinases and phosphatases, respectively) are post-translational modifications that play key roles in many eukaryotic signalling pathways, and are often deregulated in a number of pathological... Read More about A unique protein phosphatase with kelch-like domains (PPKL) in plasmodium modulates ookinete differentiation, motility and invasion.