All Outputs (10)

Circulating testosterone and dehydroepiandrosterone are associated with individual motor unit features in untrained and highly active older men (2021)
Journal Article
Guo, Y., Piasecki, J., Swiecicka, A., Ireland, A., Phillips, B. E., Atherton, P. J., …Piasecki, M. (2022). Circulating testosterone and dehydroepiandrosterone are associated with individual motor unit features in untrained and highly active older men. GeroScience, https://doi.org/10.1007/s11357-021-00482-3

Long-term exercise training has been considered as an effective strategy to counteract age-related hormonal declines and minimise muscle atrophy. However, human data relating circulating hormone levels with motor nerve function are scant. The aims of... Read More about Circulating testosterone and dehydroepiandrosterone are associated with individual motor unit features in untrained and highly active older men.

Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults (2021)
Journal Article
Din, U. S. U., Sian, T. S., Deane, C. S., Smith, K., Gates, A., Lund, J. N., …Phillips, B. E. (2021). Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults. Nutrients, 13(11), Article 3895. https://doi.org/10.3390/nu13113895

Postprandial macro-and microvascular blood flow and metabolic dysfunction manifest with advancing age, so vascular transmuting interventions are desirable. In this randomised, singleblind, placebo-controlled, crossover trial, we investigated the impa... Read More about Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults.

Six weeks of high-intensity interval training enhances contractile activity induced vascular reactivity and skeletal muscle perfusion in older adults (2021)
Journal Article
Herrod, P. J., Atherton, P. J., Smith, K., Williams, J. P., Lund, J. N., & Phillips, B. E. (2021). Six weeks of high-intensity interval training enhances contractile activity induced vascular reactivity and skeletal muscle perfusion in older adults. GeroScience, 43(6), 2667-2678. https://doi.org/10.1007/s11357-021-00463-6

Impairments in muscle microvascular function are associated with the pathogenesis of sarcopenia and cardiovascular disease. High-intensity interval training (HIIT) is an intervention by which a myriad of beneficial skeletal muscle/cardiovascular adap... Read More about Six weeks of high-intensity interval training enhances contractile activity induced vascular reactivity and skeletal muscle perfusion in older adults.

Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short-term disuse in healthy younger humans (2021)
Journal Article
Willis, C. R., Gallagher, I. J., Wilkinson, D. J., Brook, M. S., Bass, J. J., Phillips, B. E., …Atherton, P. J. (2021). Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short-term disuse in healthy younger humans. FASEB Journal, 35(9), Article e21830. https://doi.org/10.1096/fj.202100276RR

Muscle disuse leads to a rapid decline in muscle mass, with reduced muscle protein synthesis (MPS) considered the primary physiological mechanism. Here, we employed a systems biology approach to uncover molecular networks and key molecular candidates... Read More about Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short-term disuse in healthy younger humans.

Exploring the impact of COVID-19 on the willingness of older adults to participate in physiology research: views from past and potential volunteers (2021)
Journal Article
Deane, C. S., Gates, A., Traviss-Turner, G. D., Wilkinson, D. J., Smith, K., Atherton, P. J., & Phillips, B. E. (2021). Exploring the impact of COVID-19 on the willingness of older adults to participate in physiology research: views from past and potential volunteers. Applied Physiology, Nutrition, and Metabolism, 46(9), 1147-1151. https://doi.org/10.1139/apnm-2021-0204

We explored the views of older (≥65 years) past and potential volunteers in regard to participating in physiology research during the COVID-19 pandemic. Using an online questionnaire and focus groups, we found that past volunteers (n=55) were more li... Read More about Exploring the impact of COVID-19 on the willingness of older adults to participate in physiology research: views from past and potential volunteers.

Myokine Responses to Exercise in a Rat Model of Low/High Adaptive Potential (2021)
Journal Article
Farrash, W. F., Phillips, B. E., Britton, S. L., Qi, N., Koch, L. G., Wilkinson, D. J., …Atherton, P. J. (2021). Myokine Responses to Exercise in a Rat Model of Low/High Adaptive Potential. Frontiers in Endocrinology, 12, 1-10. https://doi.org/10.3389/fendo.2021.645881

Introduction: Assuming myokines underlie some of the health benefits of exercise, we hypothesised that ‘high responder trainer’ (HRT) rats would exhibit distinct myokine profiles to ‘low responder trainers’ (LRT), reflecting distinct health and adapt... Read More about Myokine Responses to Exercise in a Rat Model of Low/High Adaptive Potential.

Atrophy Resistant vs. Atrophy Susceptible skeletal muscles: “aRaS” as a novel experimental paradigm to study the mechanisms of human disuse atrophy (2021)
Journal Article
Hardy, E., Inns, T., Wilkinson, D., Piasecki, M., Atherton, P., Phillips, B., …Smith, K. (2021). Atrophy Resistant vs. Atrophy Susceptible skeletal muscles: “aRaS” as a novel experimental paradigm to study the mechanisms of human disuse atrophy. Frontiers in Psychology, 12, Article 653060. https://doi.org/10.3389/fphys.2021.653060

Objective: Disuse atrophy (DA) describes inactivity-induced skeletal muscle loss, through incompletely defined mechanisms. An intriguing observation is that individual muscles exhibit differing degrees of atrophy, despite exhibiting similar anatomica... Read More about Atrophy Resistant vs. Atrophy Susceptible skeletal muscles: “aRaS” as a novel experimental paradigm to study the mechanisms of human disuse atrophy.

Contrast‐enhanced ultrasound assessed renal microvascular perfusion may predict postoperative renal complications following colorectal surgery (2021)
Journal Article
Read, D., Doleman, B., Heinink, T., Selby, N., Lund, J., Phillips, B., & Williams, J. (2021). Contrast‐enhanced ultrasound assessed renal microvascular perfusion may predict postoperative renal complications following colorectal surgery. Clinical and Experimental Pharmacology and Physiology, 48(7), 971-977. https://doi.org/10.1111/1440-1681.13501

Colorectal surgery is associated with an above‐average mortality rate of ~15%. During surgery, maintenance of vital organ perfusion is essential in order to reduce postoperative mortality and morbidity, with renal perfusion of particular importance.... Read More about Contrast‐enhanced ultrasound assessed renal microvascular perfusion may predict postoperative renal complications following colorectal surgery.

Lifelong exercise is associated with more homogeneous motor unit potential features across deep and superficial areas of vastus lateralis (2021)
Journal Article
Jones, E. J., Piasecki, J., Ireland, A., Stashuk, D. W., Atherton, P. J., Phillips, B. E., …Piasecki, M. (2021). Lifelong exercise is associated with more homogeneous motor unit potential features across deep and superficial areas of vastus lateralis. GeroScience, 43(4), 1555-1565. https://doi.org/10.1007/s11357-021-00356-8

Motor unit (MU) expansion enables rescue of denervated muscle fibres helping to ameliorate age-relatedmuscle atrophy, with evidence to suggest master athletes are more successful at this remodelling. Electrophysiological data has suggested MUs locate... Read More about Lifelong exercise is associated with more homogeneous motor unit potential features across deep and superficial areas of vastus lateralis.

Factors associated with electrical stimulation‐induced performance fatigability are dependent upon stimulation location (2021)
Journal Article
Inns, T. B., McCormick, D., Greig, C. A., Atherton, P. J., Phillips, B. E., & Piasecki, M. (2021). Factors associated with electrical stimulation‐induced performance fatigability are dependent upon stimulation location. Experimental Physiology, 106(4), 828-836. https://doi.org/10.1113/ep089204

Neuromuscular electrical stimulation (NMES) is increasingly viewed as a central tenet to minimise muscle loss during periods of disuse/illness – typically applied directly over a muscle belly. Peripheral nerve stimulation (PNS) is afforded less atten... Read More about Factors associated with electrical stimulation‐induced performance fatigability are dependent upon stimulation location.