The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo

Bass, Joseph J.; Kazi, Abid A.; Deane, Colleen S.; Nakhuda, Asif; Ashcroft, Stephen P.; Brook, Matthew S.; Wilkinson, Daniel J.; Phillips, Bethan E.; Philp, Andrew; Tarum, Janelle; Kadi, Fawzi; Andersen, Ditte; Garcia, Amadeo Mu�oz; Smith, Ken; Gallagher, Iain J.; Szewczyk, Nathaniel J.; Cleasby, Mark E.; Atherton, Philip J.

doi:10.1113/JP280652

All Outputs (3)

A novel dietary intervention reduces circulatory branched-chain amino acids by 50%: A pilot study of relevance for obesity and diabetes (2020)
Journal Article

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Elevated circulating branched-chain amino acids (BCAAs; isoleucine, leucine, and valine) are associated with obesity and type 2 diabetes (T2D). Reducing circulatory BCAAs by dietary restrictio... Read More about A novel dietary intervention reduces circulatory branched-chain amino acids by 50%: A pilot study of relevance for obesity and diabetes.

Exploring mechanistic links between extracellular branched-chain amino acids and muscle insulin resistance: an in vitro approach (2020)
Journal Article

The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo (2020)
Journal Article

Key points: Reduced vitamin D receptor (VDR) expression prompts skeletal muscle atrophy. Atrophy occurs through catabolic processes, namely the induction of autophagy, while anabolism remains unchanged. In response to VDR-knockdown mitochondrial func... Read More about The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo.