Clusterin regulates beta-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

Killick, R.; Ribe, E. M.; Al-Shawi, R.; Malik, B.; Hooper, C.; Fernandes, C.; Dobson, R.; Nolan, P. M.; LOURDUSAMY, AROCKIA; Furney, S.; Lin, K.; Breen, G.; Wroe, R.; To, A .W.M.; Leroy, K.; Causevic, M.; Usardi, A.; Robinson, M.; Noble, W.; Williamson, R.; Lunnon, K.; Kellie, S.; Reynolds, C. H.; Bazenet, C.; Hodges, A.; Brion, J-P; Stephenson, J.; Paul Simons, J.; Lovestone, Simon

doi:10.1038/mp.2012.163

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Clusterin regulates beta-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway (2012)
Journal Article
Killick, R., Ribe, E. M., Al-Shawi, R., Malik, B., Hooper, C., Fernandes, C., …Lovestone, S. (2014). Clusterin regulates beta-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Molecular Psychiatry, 19(1), 88-98. https://doi.org/10.1038/mp.2012.163

Although the mechanism of Abaction in the pathogenesis of Alzheimer’s disease (AD) has remained elusive, it is known to increasethe expression of the antagonist of canonical wnt signalling, Dickkopf-1 (Dkk1), whereas the silencing ofDkk1blocks Abneur... Read More about Clusterin regulates beta-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway.