A method for reducing animal use whilst maintaining statistical power in electrophysiological recordings from rodent nerves

Rich, Laura R.; Patrick, Jonathan A.; Hamner, Margaret A.; Ransom, Bruce R.; Brown, Angus M.

doi:10.1016/j.heliyon.2020.e04143

All Outputs (2)

Calbindin Deficits May Underlie Dissociable Effects of 5-HT6 and mGlu7 Antagonists on Glutamate and Cognition in a Dual-Hit Neurodevelopmental Model for Schizophrenia (2020)
Journal Article

© 2020, The Author(s). Despite several compounds entering clinical trials for the negative and cognitive symptoms of schizophrenia, few have progressed beyond phase III. This is partly attributed to a need for improved preclinical models, to understa... Read More about Calbindin Deficits May Underlie Dissociable Effects of 5-HT6 and mGlu7 Antagonists on Glutamate and Cognition in a Dual-Hit Neurodevelopmental Model for Schizophrenia.

A method for reducing animal use whilst maintaining statistical power in electrophysiological recordings from rodent nerves (2020)
Journal Article

The stimulus evoked compound action potential, recorded from ex vivo nerve trunks such as the rodent optic and sciatic nerve, is a popular model system used to study aspects of nervous system metabolism. This includes (1) the role of glycogen in supp... Read More about A method for reducing animal use whilst maintaining statistical power in electrophysiological recordings from rodent nerves.