Research Repository

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Hypothermic neuroprotection during reperfusion following exposure to aglycemia in central white matter is mediated by acidification (2019)
Journal Article
Brown, A. M., Evans, R. D., Smith, P. A., Rich, L. R., & Ransom, B. R. (in press). Hypothermic neuroprotection during reperfusion following exposure to aglycemia in central white matter is mediated by acidification. Physiological Reports,

Hypoglycemia is a common iatrogenic consequence of type 1 diabetes therapy that can lead to central nervous system injury and even death if untreated. In the absence of clinically effective neuroprotective drugs we sought to quantify the putative neu... Read More

Fibre sub-type specific conduction reveals metabolic function in mouse sciatic nerve (2018)
Journal Article
Rich, L., & Brown, A. M. (2018). Fibre sub-type specific conduction reveals metabolic function in mouse sciatic nerve. Journal of Physiology, 596(10), doi:10.1113/JP275680. ISSN 0022-3751

The stimulus evoked compound action potential (CAP), recorded using suction electrodes, provides an index of the relative number of conducting axons within a nerve trunk. As such the CAP has been used to elucidate the diverse mechanisms of injury res... Read More

Acute effect of pore-forming Clostridium perfringens ε-toxin on compound action potentials of optic nerve of mouse (2017)
Journal Article
Cases, M., Brown, A., Llobet, A., Terni, B., Gómez de Aranda, I., Blanch, M., …Solsona, C. (2017). Acute effect of pore-forming Clostridium perfringens ε-toxin on compound action potentials of optic nerve of mouse. eNeuro, 4(4)(e0051-17), doi:10.1523/ENEURO.0051-17.2017

ε-Toxin is a pore forming toxin produced by Clostridium perfringens types B and D. It is synthesized as a less active prototoxin form that becomes fully active upon proteolytic activation. The toxin produces highly lethal enterotoxaemia in ruminants,... Read More

A lifetime’s adventure in extracellular K+ regulation: the Scottish connection (2017)
Journal Article
Brown, A. M. (2017). A lifetime’s adventure in extracellular K+ regulation: the Scottish connection. Neurochemical Research, 42(9), doi:10.1007/s11064-017-2319-4. ISSN 0364-3190

In a career that has spanned 45 years and shows no signs of slowing down, Dr Bruce Ransom has devoted considerable time and energy to studying regulation of interstitial K+. When Bruce commenced his studies in 1969 virtually nothing was known of the... Read More

The critical role of logarithmic transformation in Nernstian equilibrium potential calculations (2017)
Journal Article
Sawyer, J. E., Hennebry, J. E., Revill, A., & Brown, A. M. (2017). The critical role of logarithmic transformation in Nernstian equilibrium potential calculations. Advances in Physiology Education, 41(2), doi:10.1152/advan.00166.2016. ISSN 1043-4046

The membrane potential, arising from uneven distribution of ions across cell membranes containing selectively permeable ion channels, is of fundamental importance to cell signaling. The necessity of maintaining the membrane potential may be appreciat... Read More

Revision workshops in elementary mathematics enhance student performance in routine laboratory calculations (2014)
Journal Article
Sawbridge, J. L., Qureshi, H. K., Boyd, M. J., & Brown, A. M. (2014). Revision workshops in elementary mathematics enhance student performance in routine laboratory calculations. Advances in Physiology Education, 38(3), doi:10.1152/advan.00036.2014. ISSN 1043-4046

The ability to understand and implement calculations required for molarity and dilution computations that are routinely undertaken in the laboratory are essential skills that should be possessed by all students entering an undergraduate Life Sciences... Read More

Computational modeling of the effects of auditory nerve dysmyelination (2014)
Journal Article
Brown, A. M., & Hamann, M. (in press). Computational modeling of the effects of auditory nerve dysmyelination. Frontiers in Neuroanatomy, 8(73), doi:10.3389/fnana.2014.00073. ISSN 1662-5129

Our previous study showed that exposure to loud sound leading to hearing loss elongated the auditory nerve (AN) nodes of Ranvier and triggered notable morphological changes at paranodes and juxtaparanodes. Here we used computational modeling to exami... Read More

Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage (2014)
Journal Article
Yang, X., Hamner, M. A., Brown, A. M., Evans, R. D., Ye, Z., Chen, S., & Ransom, B. R. (2014). Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage. Annals of Neurology, 75(4), doi:10.1002/ana.24050. ISSN 0364-5134

Objective: Hypoglycemia is a common adverse event and can injure central nervous system (CNS) white matter (WM). We determined if glutamate receptors were involved in hypoglycemic WM injury. Methods: Mouse optic nerves (MON), CNS WM tracts, were mai... Read More