All Outputs (24)

Human epidermal growth receptor-2 overexpressing early operable primary breast cancers in older (>=70 years) women: biology and clinical outcome in comparison with younger (less than 70 years) patients (2014)
Journal Article
Syed, B., Green, A., Ellis, I., & Cheung, K. (2014). Human epidermal growth receptor-2 overexpressing early operable primary breast cancers in older (>=70 years) women: biology and clinical outcome in comparison with younger (less than 70 years) patients. Annals of Oncology, 25(4), doi:10.1093/annonc/mdu028

Introduction: There is dearth of literature reporting the prevalence and biological characteristics as well as the long-term clinical outcome of human epidermal growth factor receptor-2 (HER2) overexpressing tumours in older women. Currently, resea... Read More about Human epidermal growth receptor-2 overexpressing early operable primary breast cancers in older (>=70 years) women: biology and clinical outcome in comparison with younger (less than 70 years) patients.

Nottingham Prognostic Index Plus (NPI+): a modern clinical decision making tool in breast cancer (2014)
Journal Article
Rakha, E., Soria, D., Green, A. R., Lemetre, C., Powe, D. G., Nolan, C. C., …Ellis, I. O. (2014). Nottingham Prognostic Index Plus (NPI+): a modern clinical decision making tool in breast cancer. British Journal of Cancer, 110(7), https://doi.org/10.1038/bjc.2014.120

Current management of breast cancer (BC) relies on risk stratification based on well-defined clinicopathologic factors. Global gene expression profiling studies have demonstrated that BC comprises distinct molecular classes with clinical relevance. I... Read More about Nottingham Prognostic Index Plus (NPI+): a modern clinical decision making tool in breast cancer.

SUMOylation proteins in breast cancer (2014)
Journal Article
Alshareeda, A. T., Negm, O. H., Green, A. R., Nolan, C., Tighe, P., Albarakati, N., …Rakha, E. A. (2014). SUMOylation proteins in breast cancer. Breast Cancer Research and Treatment, 144(3), 519-530. https://doi.org/10.1007/s10549-014-2897-7

Small Ubiquitin-like Modifier proteins (or SUMO) modify the function of protein substrates involved in various cellular processes including DNA damage response (DDR). It is becoming apparent that dysregulated SUMO contribute to carcinogenesis by affe... Read More about SUMOylation proteins in breast cancer.

Characterisation of HER heterodimers in breast cancer using in situ proximity ligation assay (2014)
Journal Article
Barros, F. F., Abdel-Fatah, T. M., Moseley, P., Nolan, C. C., Durham, A. C., Rakha, E. A., …Green, A. R. (2014). Characterisation of HER heterodimers in breast cancer using in situ proximity ligation assay. Breast Cancer Research and Treatment, 144(2), 273-285. https://doi.org/10.1007/s10549-014-2871-4

HER2 plays an important role in breast cancer progression and provides predictive and prognostic information. HER2 receptor family members function through dimerisation, which can lead to impact on cell function, growth and differentiation; however,... Read More about Characterisation of HER heterodimers in breast cancer using in situ proximity ligation assay.