All Outputs (4)

A family-wide assessment of latent STAT transcription factor interactions reveals divergent dimer repertoires (2023)
Journal Article

The conversion of signal transducer and activator of transcription (STAT) proteins from latent to active transcription factors is central to cytokine signaling. Triggered by their signal-induced tyrosine phosphorylation, it is the assembly of a range... Read More about A family-wide assessment of latent STAT transcription factor interactions reveals divergent dimer repertoires.

STAT2 is a pervasive cytokine regulator due to its inhibition of STAT1 in multiple signaling pathways (2016)
Journal Article

STAT2 is the quintessential transcription factor for type 1 interferons (IFNs), where it functions as a heterodimer with STAT1. However, the human and murine STAT2-deficient phenotypes suggest important additional and currently unidentified type 1 IF... Read More about STAT2 is a pervasive cytokine regulator due to its inhibition of STAT1 in multiple signaling pathways.

STAT1-cooperative DNA binding distinguishes type 1 from type 2 interferon signaling (2014)
Journal Article

STAT1 is an indispensable component of a heterotrimer (ISGF3) and a STAT1 homodimer (GAF) that function as transcription regulators in type 1 and type 2 interferon signaling, respectively. To investigate the importance of STAT1-cooperative DNA bindin... Read More about STAT1-cooperative DNA binding distinguishes type 1 from type 2 interferon signaling.

SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFN? (2011)
Journal Article

The biologic effects of IFNγ are mediated by the transcription factor STAT1. The activity of STAT1 is inhibited by small ubiquitin-like modifier (SUMO) conjugation. This occurs both directly through decreasing STAT1 tyrosine phosphorylation and indir... Read More about SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFN?.