All Outputs (121)

Serum Levels of Proinflammatory Lipid Mediators and Specialized Proresolving Molecules Are Increased in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 and Correlate With Markers of the Adaptive Immune Response (2022)
Journal Article
Turnbull, J., Jha, R. R., Ortori, C. A., Lunt, E., Tighe, P. J., Irving, W. L., Gohir, S. A., Kim, D.-H., Valdes, A. M., Tarr, A. W., Barrett, D. A., & Chapman, V. (2022). Serum Levels of Proinflammatory Lipid Mediators and Specialized Proresolving Molecules Are Increased in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 and Correlate With Markers of the Adaptive Immune Response. Journal of Infectious Diseases, 225(12), 2142-2154. https://doi.org/10.1093/infdis/jiab632

BACKGROUND: Specialized proresolution molecules (SPMs) halt the transition to chronic pathogenic inflammation. We aimed to quantify serum levels of pro- and anti-inflammatory bioactive lipids in severe acute respiratory syndrome coronavirus 2 (SARS-C... Read More about Serum Levels of Proinflammatory Lipid Mediators and Specialized Proresolving Molecules Are Increased in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 and Correlate With Markers of the Adaptive Immune Response.

Acceptability of a nurse-led non-pharmacological complex intervention for knee pain: Nurse and patient views and experiences (2022)
Journal Article
Nomikos, P. A., Hall, M. C., Fuller, A., Ogollah, R., Valdes, A. M., Doherty, M., Walsh, D. A., das Nair, R., & Abhishek, A. (2022). Acceptability of a nurse-led non-pharmacological complex intervention for knee pain: Nurse and patient views and experiences. PLoS ONE, 17(1), Article e0262422. https://doi.org/10.1371/journal.pone.0262422

Objectives The overall purpose of this research programme is to develop and test the feasibility of a complex intervention for knee pain delivered by a nurse, and comprising both non-pharmacological and pharmacological interventions. In this first ph... Read More about Acceptability of a nurse-led non-pharmacological complex intervention for knee pain: Nurse and patient views and experiences.

Comorbidities and use of analgesics in people with knee pain: a study in the Nottingham Knee Pain and Health in the Community (KPIC) cohort (2022)
Journal Article
Swain, S., Fernandes, G. S., Sarmanova, A., Valdes, A. M., Walsh, D. A., Coupland, C., Doherty, M., & Zhang, W. (2022). Comorbidities and use of analgesics in people with knee pain: a study in the Nottingham Knee Pain and Health in the Community (KPIC) cohort. Rheumatology Advances in Practice, 6(2), Article rkac049. https://doi.org/10.1093/rap/rkac049

Objectives: The aims were to examine the prevalence of comorbidities and role of oral analgesic use in people with knee pain (KP) compared with those without. Methods: The Knee Pain and related health In the Community (KPIC) cohort comprises communit... Read More about Comorbidities and use of analgesics in people with knee pain: a study in the Nottingham Knee Pain and Health in the Community (KPIC) cohort.

Different genes may be involved in distal and local sensitization: A genome‐wide gene‐based association study and meta‐analysis (2021)
Journal Article
Kouraki, A., Doherty, M., Fernandes, G. S., Zhang, W., Walsh, D. A., Kelly, A., & Valdes, A. M. (2022). Different genes may be involved in distal and local sensitization: A genome‐wide gene‐based association study and meta‐analysis. European Journal of Pain, 26(3), 740-753. https://doi.org/10.1002/ejp.1902

Background: Neuropathic pain symptoms and signs of increased pain sensitization in osteoarthritis (OA) patients may explain persistent pain after total joint replacement (TJR). Therefore, identifying genetic markers associated with pain sensitization... Read More about Different genes may be involved in distal and local sensitization: A genome‐wide gene‐based association study and meta‐analysis.

Serum levels of specialised pro-resolving molecule pathways are greatly increased in SARS-CoV-2 patients and correlate with markers of the adaptive immune response (2021)
Preprint / Working Paper
Turnbull, J., Jha, R., Ortori, C. A., Lunt, E., Tighe, P. J., Irving, W. L., Gohir, S. A., Kim, D.-H., Valdes, A. M., Tarr, A. W., Barrett, D. A., & Chapman, V. Serum levels of specialised pro-resolving molecule pathways are greatly increased in SARS-CoV-2 patients and correlate with markers of the adaptive immune response

Background Specialised pro-resolution molecules (SPMs) halt the transition to chronic pathogenic inflammation. We aimed to quantify serum levels of pro- and anti-inflammatory bioactive lipids in SARS-CoV-2 patients, and to identify potential relation... Read More about Serum levels of specialised pro-resolving molecule pathways are greatly increased in SARS-CoV-2 patients and correlate with markers of the adaptive immune response.

The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids (2021)
Journal Article
Vijay, A., Kouraki, A., Gohir, S., Turnbull, J., Kelly, A., Chapman, V., Barrett, D. A., Bulsiewicz, W. J., & Valdes, A. M. (2021). The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids. Gut Microbes, 13(1), Article 1997559. https://doi.org/10.1080/19490976.2021.1997559

The endocannabinoid (EC) system has pleiotropic functions in the body. It plays a key role in energy homeostasis and the development of metabolic disorders being a mediator in the relationship between the gut microbiota and host metabolism. In the cu... Read More about The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids.

Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2 (2021)
Journal Article
Swadling, L., Diniz, M. O., Schmidt, N. M., Amin, O. E., Chandran, A., Shaw, E., Pade, C., Gibbons, J. M., Le Bert, N., Tan, A. T., Jeffery-Smith, A., Tan, C. C. S., Tham, C. Y. L., Kucykowicz, S., Aidoo-Micah, G., Rosenheim, J., Davies, J., Johnson, M., Jensen, M. P., Joy, G., …Investigators, C. (2022). Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2. Nature, 601(7891), 110-117. https://doi.org/10.1038/s41586-021-04186-8

Individuals with potential exposure to SARS-CoV-2 do not necessarily develop PCR or antibody positivity, suggesting some may clear sub-clinical infection before seroconversion. T-cells can contribute to the rapid clearance of SARS-CoV-2 and other cor... Read More about Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2.

Identifying multiple knee pain trajectories and the prediction of opioid and NSAID medication used: A latent class growth approach (2021)
Journal Article
Haybatollahi, S. M., James, R. J., Fernandes, G., Valdes, A., Doherty, M., Zhang, W., Walsh, D. A., & Ferguson, E. (2022). Identifying multiple knee pain trajectories and the prediction of opioid and NSAID medication used: A latent class growth approach. Pain Practice, 22(2), 210-221. https://doi.org/10.1111/papr.13082

Background: Knee pain is a major source of distress and disability, with pain progression highly variable between individuals. Previous studies defining pain trajectories have all used a single measure of pain, and these differ across studies. Differ... Read More about Identifying multiple knee pain trajectories and the prediction of opioid and NSAID medication used: A latent class growth approach.

Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): A study protocol of an efficacy mechanism evaluation (2021)
Journal Article
Al-Awadi, A., Grove, J., Taylor, M., Valdes, A., Vijay, A., Bawden, S., Gowland, P., & Aithal, G. (2021). Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): A study protocol of an efficacy mechanism evaluation. BMJ Open, 11(10), Article e045802. https://doi.org/10.1136/bmjopen-2020-045802

Introduction A Low Glycaemic Index (LGI) diet is a proposed lifestyle intervention in non-alcoholic fatty liver diseases (NAFLD) which is designed to reduce circulating blood glucose levels, hepatic glucose influx, insulin resistance and de novo lipo... Read More about Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): A study protocol of an efficacy mechanism evaluation.

Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection (2021)
Journal Article
Urbanowicz, R. A., Tsoleridis, T., Jackson, H. J., Cusin, L., Duncan, J. D., Chappell, J. G., Tarr, A. W., Nightingale, J., Norrish, A. R., Ikram, A., Marson, B., Craxford, S. J., Kelly, A., Aithal, G. P., Vijay, A., Tighe, P. J., Ball, J. K., Valdes, A. M., & Ollivere, B. J. (2021). Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection. Science Translational Medicine, 13(609), Article eabj0847. https://doi.org/10.1126/scitranslmed.abj0847

Understanding the impact of prior infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the response to vaccination is a priority for responding to the coronavirus disease 2019 (COVID-19) pandemic. In particular, it is necess... Read More about Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection.

Fidelity assessment of nurse-led non-pharmacological package of care for knee pain in the package development phase of a feasibility randomised controlled trial based in secondary care: A mixed methods study (2021)
Journal Article
Nomikos, P. A., Hall, M., Fuller, A., Millar, B., Ogollah, R., Valdes, A., Doherty, M., Walsh, D. A., Das Nair, R., & Abhishek, A. (2021). Fidelity assessment of nurse-led non-pharmacological package of care for knee pain in the package development phase of a feasibility randomised controlled trial based in secondary care: A mixed methods study. BMJ Open, 11(7), Article e045242. https://doi.org/10.1136/bmjopen-2020-045242

Objectives To evaluate fidelity of delivery of a nurse-led non-pharmacological complex intervention for knee pain. Setting Secondary care. Single-centre study. Study design Mixed methods study. Participants Eighteen adults with chronic knee pain. Inc... Read More about Fidelity assessment of nurse-led non-pharmacological package of care for knee pain in the package development phase of a feasibility randomised controlled trial based in secondary care: A mixed methods study.

Dietary interventions reduce traditional and novel cardiovascular risk markers by altering the gut microbiome and their metabolites (2021)
Journal Article
Vijay, A., Astbury, S., Panayiotis, L., Marques, F., Spector, T. D., Menni, C., & Valdes, A. M. (2021). Dietary interventions reduce traditional and novel cardiovascular risk markers by altering the gut microbiome and their metabolites. Frontiers in Cardiovascular Medicine, 8, Article 691564. https://doi.org/10.3389/fcvm.2021.691564

Aims: The current study investigates the role of diet in mediating the gut microbiome-cardiovascular association which has not
yet been explored in humans.
Methods and results: Using a two-arm dietary intervention study in healthy participants (N=7... Read More about Dietary interventions reduce traditional and novel cardiovascular risk markers by altering the gut microbiome and their metabolites.

Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study. (2021)
Journal Article
Menni, C., Klaser, K., May, A., Polidori, L., Capdevila, J., Louca, P., Sudre, C. H., Nguyen, L. H., Drew, D. A., Merino, J., Hu, C., Selvachandran, S., Antonelli, M., Murray, B., Canas, L. S., Molteni, E., Graham, M. S., Modat, M., Joshi, A. D., Mangino, M., …Spector, T. D. (2021). Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study. Lancet Infectious Diseases, 21(7), 939-949. https://doi.org/10.1016/s1473-3099%2821%2900224-3

Background
The Pfizer-BioNTech (BNT162b2) and the Oxford-AstraZeneca (ChAdOx1 nCoV-19) COVID-19 vaccines have shown excellent safety and efficacy in phase 3 trials. We aimed to investigate the safety and effectiveness of these vaccines in a UK commu... Read More about Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study..

Associations of peripheral and central pain mechanisms with voluntary muscle strength in people with knee pain (2021)
Journal Article
Yue, B., McWilliams, D., Smith, S., Stocks, J., Sarmanova, A., Fernandes, G., Swaithes, L., Frowd, N., Doherty, M., Zhang, W., Valdes, A., Hall, M., & Walsh, D. (2021). Associations of peripheral and central pain mechanisms with voluntary muscle strength in people with knee pain. Osteoarthritis and Cartilage, 29(Suppl 1), S366-S367. https://doi.org/10.1016/j.joca.2021.02.475

Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose (2021)
Journal Article
Reynolds, C. J., Pade, C., Gibbons, J. M., Butler, D. K., Otter, A. D., Menacho, K., Fontana, M., Smit, A., Sackville-West, J. E., Cutino-Moguel, T., Maini, M. K., Chain, B., Noursadeghi, M., Brooks, T., Semper, A., Manisty, C., Treibel, T. A., Moon, J. C., Valdes, A. M., McKnight, Á., …UK COVIDsortium Investigators. (2021). Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose. Science, 372(6549), 1418-1423. https://doi.org/10.1126/science.abh1282

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine rollout has coincided with the spread of variants of concern. We investigated whether single-dose vaccination, with or without prior infection, confers cross-protective immunity to... Read More about Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose.

Modest effects of dietary supplements during the COVID-19 pandemic: insights from 445 850 users of the COVID-19 Symptom Study app (2021)
Journal Article
Louca, P., Murray, B., Klaser, K., Graham, M. S., Mazidi, M., Leeming, E. R., Thompson, E., Bowyer, R., Drew, D. A., Nguyen, L. H., Merino, J., Gomez, M., Mompeo, O., Costeira, R., Sudre, C. H., Gibson, R., Steves, C. J., Wolf, J., Franks, P. W., Ourselin, S., …Menni, C. (2021). Modest effects of dietary supplements during the COVID-19 pandemic: insights from 445 850 users of the COVID-19 Symptom Study app. BMJ Nutrition, Prevention & Health, 4(1), Article e000250. https://doi.org/10.1136/bmjnph-2021-000250

Objectives Dietary supplements may ameliorate SARS-CoV-2 infection, although scientific evidence to support such a role is lacking. We investigated whether users of the COVID-19 Symptom Study app who regularly took dietary supplements were less likel... Read More about Modest effects of dietary supplements during the COVID-19 pandemic: insights from 445 850 users of the COVID-19 Symptom Study app.

Longitudinal assessment of symptoms and risk of SARS-CoV-2 infection in healthcare workers across 5 hospitals to understand ethnic differences in infection risk. (2021)
Journal Article
Valdes, A. M., Moon, J. C., Vijay, A., Chaturvedi, N., Norrish, A., Ikram, A., Craxford, S., Cusin, L. M., Nightingale, J., Semper, A., Brooks, T., McKnight, A., Kurdi, H., Menni, C., Tighe, P., Noursadeghi, M., Aithal, G., Treibel, T. A., Ollivere, B. J., & Manisty, C. (2021). Longitudinal assessment of symptoms and risk of SARS-CoV-2 infection in healthcare workers across 5 hospitals to understand ethnic differences in infection risk. eClinicalMedicine, 34, Article 100835. https://doi.org/10.1016/j.eclinm.2021.100835

Background:: Healthcare workers (HCWs) have increased rates of SARS-CoV-2 infection compared with the general population. We aimed to understand ethnic differences in SARS-CoV-2 seropositivity among hospital healthcare workers depending on their hosp... Read More about Longitudinal assessment of symptoms and risk of SARS-CoV-2 infection in healthcare workers across 5 hospitals to understand ethnic differences in infection risk..

Postprandial glycaemic dips predict appetite and energy intake in healthy individuals (2021)
Journal Article
Wyatt, P., Berry, S. E., Finlayson, G., O’Driscoll, R., Hadjigeorgiou, G., Drew, D. A., Khatib, H. A., Nguyen, L. H., Linenberg, I., Chan, A. T., Spector, T. D., Franks, P. W., Wolf, J., Blundell, J., & Valdes, A. M. (2021). Postprandial glycaemic dips predict appetite and energy intake in healthy individuals. Nature Metabolism, 3, 523–529. https://doi.org/10.1038/s42255-021-00383-x

Understanding how to modulate appetite in humans is key to developing successful weight loss interventions. Here, we showed that postprandial glucose dips 2–3 h after a meal are a better predictor of postprandial self-reported hunger and subsequent e... Read More about Postprandial glycaemic dips predict appetite and energy intake in healthy individuals.

β-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: A propensity score-matched cohort study (2021)
Journal Article
Nakafero, G., Grainge, M. J., Valdes, A. M., Townsend, N., D. Mallen, C., Zhang, W., Doherty, M., Mamas, M., & Abhishek, A. (2021). β-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: A propensity score-matched cohort study. Rheumatology, 60(12), 5686-5696. https://doi.org/10.1093/rheumatology/keab234

Objectives: To examine the association between β-blocker prescription and first primary-care consultation for knee OA, hip OA, knee pain and hip pain. Methods: Data source: Clinical Practice Research Datalink. Participants aged ≥40 years in receipt o... Read More about β-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: A propensity score-matched cohort study.

Metabolic signatures of osteoarthritis in urine using liquid chromatography‐high resolution tandem mass spectrometry (2021)
Journal Article
Abdelrazig, S., Ortori, C. A., Doherty, M., Valdes, A. M., Chapman, V., & Barrett, D. A. (2021). Metabolic signatures of osteoarthritis in urine using liquid chromatography‐high resolution tandem mass spectrometry. Metabolomics, 17(3), Article 29. https://doi.org/10.1007/s11306-021-01778-3

Introduction: Osteoarthritis (OA) is a common cause of disability in older people, but its aetiology is not yet fully understood. Biomarkers of OA from metabolomics studies have shown potential use in understanding the progression and pathophysiology... Read More about Metabolic signatures of osteoarthritis in urine using liquid chromatography‐high resolution tandem mass spectrometry.