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Serum Levels of Proinflammatory Lipid Mediators and Specialized Proresolving Molecules Are Increased in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 and Correlate With Markers of the Adaptive Immune Response

Turnbull, James; Jha, Rakesh R.; Ortori, Catherine A.; Lunt, Eleanor; Tighe, Patrick J.; Irving, William L; Gohir, Sameer A.; Kim, Dong-Hyun; Valdes, Ana M; Tarr, Alexander W.; Barrett, David A.; Chapman, Victoria

Serum Levels of Proinflammatory Lipid Mediators and Specialized Proresolving Molecules Are Increased in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 and Correlate With Markers of the Adaptive Immune Response Thumbnail


Authors

Rakesh R. Jha

Catherine A. Ortori

Eleanor Lunt

PATRICK TIGHE paddy.tighe@nottingham.ac.uk
Professor of Molecular Immunology

Sameer A. Gohir

David A. Barrett



Abstract

BACKGROUND: Specialized proresolution molecules (SPMs) halt the transition to chronic pathogenic inflammation. We aimed to quantify serum levels of pro- and anti-inflammatory bioactive lipids in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients, and to identify potential relationships with innate responses and clinical outcome.

METHODS: Serum from 50 hospital admitted inpatients (22 female, 28 male) with confirmed symptomatic SARS-CoV-2 infection and 94 age- and sex-matched controls collected prior to the pandemic (SARS-CoV-2 negative), were processed for quantification of bioactive lipids and anti-nucleocapsid and anti-spike quantitative binding assays.

RESULTS: SARS-CoV-2 serum had significantly higher concentrations of omega-6-derived proinflammatory lipids and omega-6- and omega-3-derived SPMs, compared to the age- and sex-matched SARS-CoV-2-negative group, which were not markedly altered by age or sex. There were significant positive correlations between SPMs, proinflammatory bioactive lipids, and anti-spike antibody binding. Levels of some SPMs were significantly higher in patients with an anti-spike antibody value >0.5. Levels of linoleic acid and 5,6-dihydroxy-8Z,11Z,14Z-eicosatrienoic acid were significantly lower in SARS-CoV-2 patients who died.

CONCLUSIONS: SARS-CoV-2 infection was associated with increased levels of SPMs and other pro- and anti-inflammatory bioactive lipids, supporting the future investigation of the underlying enzymatic pathways, which may inform the development of novel treatments.

Journal Article Type Article
Acceptance Date Jan 2, 2022
Online Publication Date Jan 3, 2022
Publication Date Jun 15, 2022
Deposit Date Sep 8, 2022
Publicly Available Date Sep 8, 2022
Journal The Journal of Infectious Diseases
Print ISSN 0022-1899
Electronic ISSN 1537-6613
Publisher Oxford University Press (OUP)
Peer Reviewed Peer Reviewed
Volume 225
Issue 12
Pages 2142-2154
DOI https://doi.org/10.1093/infdis/jiab632
Keywords Infectious Diseases; Immunology and Allergy
Public URL https://nottingham-repository.worktribe.com/output/8771199
Publisher URL https://academic.oup.com/jid/article/225/12/2142/6494537