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Bidirectional association between disturbed sleep and neuropathic pain symptoms: a prospective cohort study in post-total joint replacement participants (2018)
Journal Article
Stocks, J., Tang, N. K., Walsh, D. A., Warner, S. C., Harvey, H., Jenkins, W., Abhishek, A., Doherty, M., & Valdes, A. M. (2018). Bidirectional association between disturbed sleep and neuropathic pain symptoms: a prospective cohort study in post-total joint replacement participants. Journal of Pain Research, 2018(11), 1087—1093. https://doi.org/10.2147/JPR.S149830

Disturbed sleep is strongly correlated with chronic pain. The aim of this study was to examine the association between sleep disturbance and incident joint pain focusing on neuropathic pain-like symptoms. 423 individuals who had undergone total joint... Read More about Bidirectional association between disturbed sleep and neuropathic pain symptoms: a prospective cohort study in post-total joint replacement participants.

The fecal metabolome as a functional readout of the gut microbiome (2018)
Journal Article
Zierer, J., Jackson, M. A., Kastenmüller, G., Mangino, M., Long, T., Telenti, A., …Menni, C. (2018). The fecal metabolome as a functional readout of the gut microbiome. Nature Genetics, 50(6), 790-795. https://doi.org/10.1038/s41588-018-0135-7

© 2018 The Author(s). The human gut microbiome plays a key role in human health 1 , but 16S characterization lacks quantitative functional annotation 2 . The fecal metabolome provides a functional readout of microbial activity and can be used as an... Read More about The fecal metabolome as a functional readout of the gut microbiome.

Glycosylation profile of immunoglobulin G is cross-sectionally associated with cardiovascular disease risk score and subclinical atherosclerosis in two independent cohorts (2018)
Journal Article
Menni, C., Gudelj, I., Macdonald-Dunlop, E., Mangino, M., Zierer, J., Bešić, E., …Valdes, A. (2018). Glycosylation profile of immunoglobulin G is cross-sectionally associated with cardiovascular disease risk score and subclinical atherosclerosis in two independent cohorts. Circulation Research, 122(11), 1555-1564. https://doi.org/10.1161/CIRCRESAHA.117.312174

Rationale: One measure of protein glycosylation (GlycA) has been reported to predict higher cardiovascular risk by reflecting inflammatory pathways. Objective: The main objective of this study is to assess the role of a comprehensive panel of Ig... Read More about Glycosylation profile of immunoglobulin G is cross-sectionally associated with cardiovascular disease risk score and subclinical atherosclerosis in two independent cohorts.

Effect of dietary omega-3 fatty acid supplementation on frailty related phenotypes in older adults: a systematic review and meta-analysis protocol (2018)
Journal Article
Stocks, J., & Valdes, A. M. (2018). Effect of dietary omega-3 fatty acid supplementation on frailty related phenotypes in older adults: a systematic review and meta-analysis protocol. BMJ Open, 8(5), Article e021344. https://doi.org/10.1136/bmjopen-2017-021344

Introduction: The beneficial effect of dietary omega-3 supplementation in younger adults or older people with acute or chronic disease is established. Knowledge is now needed about the effect in medically stable older people. The objective of this st... Read More about Effect of dietary omega-3 fatty acid supplementation on frailty related phenotypes in older adults: a systematic review and meta-analysis protocol.

Gut microbial diversity is associated with lower arterial stiffness in women (2018)
Journal Article
Valdes, A. M., Menni, C., Lin, C., Cecelja, M., Mangino, M., Matey-Hernandez, M. L., …Chowienczyk, P. (2018). Gut microbial diversity is associated with lower arterial stiffness in women. European Heart Journal, 39(25), 2390a-2397a. https://doi.org/10.1093/eurheartj/ehy226

© The Author(s)2018 All rights reserved. Aims The gut microbiome influences metabolic syndrome (MetS) and inflammation and is therapeutically modifiable. Arterial stiffness is poorly correlated with most traditional risk factors. Our aim was to exam... Read More about Gut microbial diversity is associated with lower arterial stiffness in women.

A clinical assessment tool to improve the use of pain relieving treatments in knee osteoarthritis (2018)
Presentation / Conference Contribution
Akin-Akinyosoye, K., Frowd, N., Marshall, L., Stocks, J., Fernandes, G., Valdes, A., McWilliams, D., Zhang, W., Doherty, M., Ferguson, E., & Walsh, D. (2018, April). A clinical assessment tool to improve the use of pain relieving treatments in knee osteoarthritis. Presented at 2018 OARSI World Congress on Osteoarthritis : Promoting Clinical and Basic Research in Osteoarthritis, Liverpool, United Kingdom

Purpose: Approximately 1 in 4 individuals in the UK over the age of 55 experience knee pain (KP), predominantly due to osteoarthritis (OA). Following treatment targeted at the affected knee, pain relief is reported in only 60%–80% of individuals with... Read More about A clinical assessment tool to improve the use of pain relieving treatments in knee osteoarthritis.

Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability (2018)
Journal Article
Hysi, P. G., Valdes, A. M., Liu, F., Furlotte, N. A., Evans, D. M., Bataille, V., …Spector, T. D. (2018). Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability. Nature Genetics, 50(5), 652-656. https://doi.org/10.1038/s41588-018-0100-5

© 2018 The Author(s). Hair color is one of the most recognizable visual traits in European populations and is under strong genetic control. Here we report the results of a genome-wide association study meta-analysis of almost 300,000 participants of... Read More about Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability.

Osteoarthritis and ageing (2018)
Journal Article
Valdes, A. M., & Stocks, J. (2018). Osteoarthritis and ageing. European Medical Journal Rheumatology, 3(1),

Ageing is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death, the rate and extent of which varies among individuals. Osteoarthritis (OA) is not only... Read More about Osteoarthritis and ageing.

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels (2018)
Journal Article
Jiang, X., O’Reilly, P. F., Aschard, H., Hsu, Y.-H., Richards, J. B., Dupuis, J., …Kiel, D. P. (2018). Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. Nature Communications, 9(1), Article 260. https://doi.org/10.1038/s41467-017-02662-2

Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). I... Read More about Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.

Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study (2017)
Journal Article
Abhishek, A., Valdes, A. M., Jenkins, W., Zhang, W., & Doherty, M. (2017). Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study. PLoS ONE, 12(10), Article e0186096. https://doi.org/10.1371/journal.pone.0186096

Objectives To determine the proportion of people with gout who self-report triggers of acute attacks; identify the commonly reported triggers, and examine the disease and demographic features associated with self-reporting any trigger(s) of acute... Read More about Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study.

Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans (2017)
Journal Article
Valdes, A. M., Ravipati, S., Menni, C., Abhishek, A., Metrustry, S., Harris, J., Nessa, A., Williams, F. M., Spector, T. D., Doherty, M., Chapman, V., & Barrett, D. A. (in press). Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans. Scientific Reports, 7, Article 10748. https://doi.org/10.1038/s41598-017-09516-3

Resolvins are omega-3 fatty acid derived potent bioactive lipids that resolve inflammation and modulate transient receptor potential channels. Exogenous administration of the resolvin precursor 17-HDHA shows a strong analgesic effect in animal models... Read More about Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans.

Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand (2017)
Journal Article
Hollander, W. D., Boer, C. G., Hart, D. J., Yau, M. S., Ramos, Y. F., Metrustry, S., Broer, L., Deelen, J., Cupples, L. A., Rivadeneira, F., Kloppenburg, M., Peters, M., Spector, T. D., Hofman, A., Slagboom, P. E., Nelissen, R. G., Uitterlinden, A. G., Felson, D. T., Valdes, A. M., Meulenbelt, I., & van Meurs, J. J. (2017). Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand. Annals of the Rheumatic Diseases, https://doi.org/10.1136/annrheumdis-2017-211214

Objective Osteoarthritis (OA) is the most common form of arthritis and the leading cause of disability in the elderly. Of all the joints, genetic predisposition is strongest for OA of the hand; however, only few genetic risk loci for hand OA have bee... Read More about Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand.

Association of beta-blocker use with less prevalent joint pain and lower opioid requirement in people with osteoarthritis (2017)
Journal Article
Valdes, A. M., Abhishek, A., Muir, K., Zhang, W., Maciewicz, R. A., & Doherty, M. (2017). Association of beta-blocker use with less prevalent joint pain and lower opioid requirement in people with osteoarthritis. Arthritis Care and Research, 69(7), 1076-1081. https://doi.org/10.1002/acr.23091

Objective: Recent findings suggest that β-adrenergic blockers have anti-nociceptive properties. The aim of this study was to compare levels of large joint pain between those on adrenergic blockers and those on other antihypertensive medications. Met... Read More about Association of beta-blocker use with less prevalent joint pain and lower opioid requirement in people with osteoarthritis.

Familial aggregation of rheumatoid arthritis and co-aggregation of autoimmune diseases in affected families: a nationwide population-based study (2017)
Journal Article
Kuo, C. F., Grainge, M. J., Valdes, A. M., See, L. C., Yu, K. H., Steven Shaw, S. W., …Doherty, M. (2017). Familial aggregation of rheumatoid arthritis and co-aggregation of autoimmune diseases in affected families: a nationwide population-based study. Rheumatology, 56(6), 928-933. https://doi.org/10.1093/rheumatology/kew500

© The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. Objective. The aim was to estimate familial relative risk (RR) for RA and other autoimmune diseases and the genetic contri... Read More about Familial aggregation of rheumatoid arthritis and co-aggregation of autoimmune diseases in affected families: a nationwide population-based study.

Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study (2016)
Journal Article
Inflammation Working Group of the CHARGE Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, International Consortium for Blood Pressure, GERAD1 Consortium, CKDGen consortium, Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, …Alizadeh, B. Z. (2016). Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study. PLoS Medicine, 13(6), e1001976. https://doi.org/10.1371/journal.pmed.1001976

Background C-reactive protein (CRP) is associated with immune, cardiometabolic, and psychiatric traits and diseases. Yet it is inconclusive whether these associations are causal. Methods and Findings We performed Mendelian randomization (MR)... Read More about Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study.

Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families (2015)
Journal Article
Kuo, C.-F., Grainge, M. J., Valdes, A. M., See, L.-C., Luo, S.-F., Yu, K.-H., …Doherty, M. (2015). Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families. JAMA Internal Medicine, 175(9), 1518-1526. https://doi.org/10.1001/jamainternmed.2015.3528

IMPORTANCE: Relatives of patients with systemic lupus erythematosus (SLE) appear to be at higher risk of SLE and other autoimmune diseases, but estimates of individual familial risks are largely unavailable or unreliable. Furthermore, relative contri... Read More about Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families.