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All Outputs (19)

Different genes may be involved in distal and local sensitization: A genome‐wide gene‐based association study and meta‐analysis (2021)
Journal Article

Background: Neuropathic pain symptoms and signs of increased pain sensitization in osteoarthritis (OA) patients may explain persistent pain after total joint replacement (TJR). Therefore, identifying genetic markers associated with pain sensitization... Read More about Different genes may be involved in distal and local sensitization: A genome‐wide gene‐based association study and meta‐analysis.

The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids (2021)
Journal Article

The endocannabinoid (EC) system has pleiotropic functions in the body. It plays a key role in energy homeostasis and the development of metabolic disorders being a mediator in the relationship between the gut microbiota and host metabolism. In the cu... Read More about The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids.

Identifying multiple knee pain trajectories and the prediction of opioid and NSAID medication used: A latent class growth approach (2021)
Journal Article

Background: Knee pain is a major source of distress and disability, with pain progression highly variable between individuals. Previous studies defining pain trajectories have all used a single measure of pain, and these differ across studies. Differ... Read More about Identifying multiple knee pain trajectories and the prediction of opioid and NSAID medication used: A latent class growth approach.

Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): A study protocol of an efficacy mechanism evaluation (2021)
Journal Article

Introduction A Low Glycaemic Index (LGI) diet is a proposed lifestyle intervention in non-alcoholic fatty liver diseases (NAFLD) which is designed to reduce circulating blood glucose levels, hepatic glucose influx, insulin resistance and de novo lipo... Read More about Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): A study protocol of an efficacy mechanism evaluation.

Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection (2021)
Journal Article

Understanding the impact of prior infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the response to vaccination is a priority for responding to the coronavirus disease 2019 (COVID-19) pandemic. In particular, it is necess... Read More about Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection.

Fidelity assessment of nurse-led non-pharmacological package of care for knee pain in the package development phase of a feasibility randomised controlled trial based in secondary care: A mixed methods study (2021)
Journal Article

Objectives To evaluate fidelity of delivery of a nurse-led non-pharmacological complex intervention for knee pain. Setting Secondary care. Single-centre study. Study design Mixed methods study. Participants Eighteen adults with chronic knee pain. Inc... Read More about Fidelity assessment of nurse-led non-pharmacological package of care for knee pain in the package development phase of a feasibility randomised controlled trial based in secondary care: A mixed methods study.

Dietary interventions reduce traditional and novel cardiovascular risk markers by altering the gut microbiome and their metabolites (2021)
Journal Article

Aims: The current study investigates the role of diet in mediating the gut microbiome-cardiovascular association which has not yet been explored in humans. Methods and results: Using a two-arm dietary intervention study in healthy participants (N=7... Read More about Dietary interventions reduce traditional and novel cardiovascular risk markers by altering the gut microbiome and their metabolites.

Modest effects of dietary supplements during the COVID-19 pandemic: insights from 445 850 users of the COVID-19 Symptom Study app (2021)
Journal Article

Objectives Dietary supplements may ameliorate SARS-CoV-2 infection, although scientific evidence to support such a role is lacking. We investigated whether users of the COVID-19 Symptom Study app who regularly took dietary supplements were less likel... Read More about Modest effects of dietary supplements during the COVID-19 pandemic: insights from 445 850 users of the COVID-19 Symptom Study app.

Longitudinal assessment of symptoms and risk of SARS-CoV-2 infection in healthcare workers across 5 hospitals to understand ethnic differences in infection risk. (2021)
Journal Article

Background:: Healthcare workers (HCWs) have increased rates of SARS-CoV-2 infection compared with the general population. We aimed to understand ethnic differences in SARS-CoV-2 seropositivity among hospital healthcare workers depending on their hosp... Read More about Longitudinal assessment of symptoms and risk of SARS-CoV-2 infection in healthcare workers across 5 hospitals to understand ethnic differences in infection risk..

?-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: A propensity score-matched cohort study (2021)
Journal Article

Objectives: To examine the association between ?-blocker prescription and first primary-care consultation for knee OA, hip OA, knee pain and hip pain. Methods: Data source: Clinical Practice Research Datalink. Participants aged ?40 years in receipt o... Read More about ?-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: A propensity score-matched cohort study.

Metabolic signatures of osteoarthritis in urine using liquid chromatography?high resolution tandem mass spectrometry (2021)
Journal Article

Introduction: Osteoarthritis (OA) is a common cause of disability in older people, but its aetiology is not yet fully understood. Biomarkers of OA from metabolomics studies have shown potential use in understanding the progression and pathophysiology... Read More about Metabolic signatures of osteoarthritis in urine using liquid chromatography?high resolution tandem mass spectrometry.

Serum glucose, lactate dehydrogenase and hypertension are mediators of the 1 effect of body mass index on severity of COVID-19 (2021)
Journal Article

Background: COVID-19 has a broad clinical specturm. We investigated the role of serum markers measured on admission on severity as assessed at discharge and investigated those which relate to the effect of BMI on severity. Methods: Clinical and la... Read More about Serum glucose, lactate dehydrogenase and hypertension are mediators of the 1 effect of body mass index on severity of COVID-19.

High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome (2021)
Journal Article

Background: Chronic inflammation, which can be modulated by diet, is linked to high white blood cell counts and correlates with higher cardiometabolic risk and risk of more severe infections, as in the case of COVID-19. Methods: Here, we assessed th... Read More about High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome.

Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals (2021)
Journal Article

The gut microbiome is shaped by diet and influences host metabolism; however, these links are complex and can be unique to each individual. We performed deep metagenomic sequencing of 1,203 gut microbiomes from 1,098 individuals enrolled in the Perso... Read More about Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals.