All Outputs (105)

Biomimetic Human Lung Models (2014)
Book Chapter
Harrington, H. C., Cato, P. A., & Ghaemmaghami, A. M. (2014). Biomimetic Human Lung Models. In Handbook of Biomimetics and Bioinspiration (1017-1036). World Scientific. https://doi.org/10.1142/9789814354936_0037

New strategies for the treatment of lung disease are being sought to combat the increased prevalence of lung disease within the developedworld.As researchmoves away from reliance upon the use of animal models in pre-clinical studies innovative method... Read More about Biomimetic Human Lung Models.

A hybrid PDMS/paper passive pump for slow-release/delivery of drugs in chronic dermal wounds (2014)
Presentation / Conference Contribution
Rahimi, R., Ochoa, M., Zhou, J., Tamayol, A., Dokmeci, M. R., Khademhosseini, A., …Ziaie, B. (2014). A hybrid PDMS/paper passive pump for slow-release/delivery of drugs in chronic dermal wounds. In Proceedings of 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (2205-2207)

© 14CBMS. In this paper, we present a hybrid PDMS/paper-based passive pump for slow drug delivery in chronic wounds. The pump consists of a PDMS microfluidic network that is irreversibly bonded to the polyethylene-coated (hydrophobic) side of a comme... Read More about A hybrid PDMS/paper passive pump for slow-release/delivery of drugs in chronic dermal wounds.

Surgical materials: Current challenges and nano-enabled solutions (2014)
Journal Article
Annabi, N., Tamayol, A., Shin, S. R., Ghaemmaghami, A. M., Peppas, N. A., & Khademhosseini, A. (2014). Surgical materials: Current challenges and nano-enabled solutions. Nano Today, 9(5), 574-589. https://doi.org/10.1016/j.nantod.2014.09.006

© 2014 Elsevier Ltd. All rights reserved. Surgical adhesive biomaterials have emerged as substitutes to sutures and staples in many clinical applications. Nano-enabled materials containing nanoparticles or having a distinct nanotopography have been u... Read More about Surgical materials: Current challenges and nano-enabled solutions.

Utilizing nanosensor-incorporated scaffolds in the development of a 3D lung model (2014)
Book Chapter
Harrington, H. C., Rose, F. R., Ghaemmaghami, A. M., & Aylott, J. W. (2014). Utilizing nanosensor-incorporated scaffolds in the development of a 3D lung model. In J. Haycock, A. Ahluwalia, & J. M. Wilkinson (Eds.), Cellular In Vitro Testing (89-107). Jenny Stanford Publishing

Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds (2014)
Journal Article
Morris, G., Bridge, J., Eltboli, O., Lewis, M., Knox, A., Aylott, J. W., …Rose, F. R. (2014). Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds. AJP - Lung Cellular and Molecular Physiology, 307(1), Article L38-L47. https://doi.org/10.1152/ajplung.00318.2013

Human airway smooth muscle (HASM) contraction plays a central role in regulating airway resistance in both healthy and asthmatic bronchioles. In vitro studies that investigate the intricate mechanisms that regulate this contractile process are predom... Read More about Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds.

A janus-paper PDMS platform for lab-on-a-chip applications (2014)
Presentation / Conference Contribution
Rahimi, R., Ochoa, M., Parupudi, T., Donaldson, A., Dokmeci, M. R., Khademhosseini, A., …Ziaie, B. (2014). A janus-paper PDMS platform for lab-on-a-chip applications. In Solid-State Sensors, Actuators, and Microsystems Workshop (119-122). https://doi.org/10.31438/trf.hh2014.34

© 2014TRF. A commercially available Janus paper with one hydrophobic (polyethylene-coated) face and a hygroscopic/hydrophilic one is irreversibly bonded to a PDMS substrate incorporating microfluidic channels via corona discharge surface treatment. T... Read More about A janus-paper PDMS platform for lab-on-a-chip applications.

Handbook Of Biomimetics And Bioinspiration: Biologically-driven Engineering Of Materials, Processes, Devices, And Systems (2014)
Book
Jabbari, E., Kim, D. H., Lee, L. P., Ghaemmaghami, A., & Khademhosseini, A. (2014). Handbook Of Biomimetics And Bioinspiration: Biologically-driven Engineering Of Materials, Processes, Devices, And Systems. World Scientific. https://doi.org/10.1142/8169

Global warming, pollution, food and water shortage, cyberspace insecurity, over-population, land erosion, and an overburdened health care system are major issues facing the human race and our planet. These challenges have presented a mandate to devel... Read More about Handbook Of Biomimetics And Bioinspiration: Biologically-driven Engineering Of Materials, Processes, Devices, And Systems.

Front matter (2014)
Book Chapter
Jabbari, E., Kim, D. H., Lee, L. P., Ghaemmaghami, A., & Khademhosseini, A. (2014). Front matter. In E. Jabbari, D. Ho Kim, L. P. Lee, A. Ghaemmaghami, & A. Khademhosseini (Eds.), Handbook of Biomimetics and Bioinspiration: Biologically-driven Engineering of Materials, Processes, Devices, and Systems (i-lix). World Scientific. https://doi.org/10.1142/9789814354936_fmatter01

Direct-write bioprinting of cell-laden methacrylated gelatin hydrogels (2014)
Journal Article
Bertassoni, L. E., Cardoso, J. C., Manoharan, V., Cristino, A. L., Bhise, N. S., Araujo, W. A., …Khademhosseini, A. (2015). Direct-write bioprinting of cell-laden methacrylated gelatin hydrogels. Biofabrication, 6(2), 1-11. https://doi.org/10.1088/1758-5082/6/2/024105

Fabrication of three dimensional (3D) organoids with controlled microarchitectures has been shown to enhance tissue functionality. Bioprinting can be used to precisely position cells and cell-laden materials to generate controlled tissue architecture... Read More about Direct-write bioprinting of cell-laden methacrylated gelatin hydrogels.

An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells (2013)
Journal Article
Sharquie, I. K., Al-Ghouleh, A., Fitton, P., Clark, M. R., Armour, K. L., Sewell, H. F., …Ghaemmaghami, A. M. (2013). An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells. BMC Immunology, 14(Decemb), Article 12. https://doi.org/10.1186/1471-2172-14-54

Background: Allergen recognition by dendritic cells (DCs) is a key event in the allergic cascade leading to production of IgE antibodies. C-type lectins, such as the mannose receptor and DC-SIGN, were recently shown to play an important role in the u... Read More about An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells.

Post-processing of polymer foam tissue scaffolds with high power ultrasound: A route to increased pore interconnectivity, pore size and fluid transport (2013)
Journal Article
Watson, N. J., Johal, R. K., Glover, Z., Reinwald, Y., White, L. J., Ghaemmaghami, A. M., …Parker, N. G. (2013). Post-processing of polymer foam tissue scaffolds with high power ultrasound: A route to increased pore interconnectivity, pore size and fluid transport. Materials Science and Engineering: C, 33(8), 4825-4832. https://doi.org/10.1016/j.msec.2013.07.046

The aimof this work is to demonstrate that the structural and fluidic properties of polymer foamtissue scaffolds, post-fabrication but prior to the introduction of cells, can be engineered via exposure to high power ultrasound. Our analysis is suppor... Read More about Post-processing of polymer foam tissue scaffolds with high power ultrasound: A route to increased pore interconnectivity, pore size and fluid transport.

Self-reporting Scaffolds for 3-Dimensional Cell Culture (2013)
Journal Article
Harrington, H., Rose, F. R., Aylott, J. W., & Ghaemmaghami, A. M. (2013). Self-reporting Scaffolds for 3-Dimensional Cell Culture. Journal of Visualized Experiments, https://doi.org/10.3791/50608

Culturing cells in 3D on appropriate scaffolds is thought to better mimic the in vivo microenvironment and increase cell-cell interactions. The resulting 3D cellular construct can often be more relevant to studying the molecular events and cell-cell... Read More about Self-reporting Scaffolds for 3-Dimensional Cell Culture.

Allergen recognition by innate immune cells: critical role of dendritic and epithelial cells (2013)
Journal Article
Salazar, F., & Ghaemmaghami, A. M. (2013). Allergen recognition by innate immune cells: critical role of dendritic and epithelial cells. Frontiers in Immunology, 4, Article 356. https://doi.org/10.3389/fimmu.2013.00356

Allergy is an exacerbated response of the immune system against non-self-proteins called allergens and is typically characterized by biased type-2 T helper cell and deleterious IgE mediated immune responses. The allergic cascade starts with the recog... Read More about Allergen recognition by innate immune cells: critical role of dendritic and epithelial cells.

Interconnectivity and permeability of supercritical fluid-foamed scaffolds and the effect of their structural properties on cell distribution (2013)
Journal Article
Reinwald, Y., Johal, R. K., Ghaemmaghami, A. M., Rose, F. R., Howdle, S. M., & Shakesheff, K. M. (2014). Interconnectivity and permeability of supercritical fluid-foamed scaffolds and the effect of their structural properties on cell distribution. Polymer, 55(1), 435-444. https://doi.org/10.1016/j.polymer.2013.09.041

This study aims to investigate interconnectivity and permeability of scCO2-foamed scaffolds and the influence of structural scaffold properties on cell distribution. Supercritical fluid technology was utilized to fabricated scaffolds from 37 kDa, 53... Read More about Interconnectivity and permeability of supercritical fluid-foamed scaffolds and the effect of their structural properties on cell distribution.

Engineering functional epithelium for regenerative medicine and in vitro organ models: A review (2013)
Journal Article
Vrana, N. E., Lavalle, P., Dokmeci, M. R., Dehghani, F., Ghaemmaghami, A. M., & Khademhosseini, A. (2013). Engineering functional epithelium for regenerative medicine and in vitro organ models: A review. Tissue Engineering Part B: Reviews, 19(6), 529-543. https://doi.org/10.1089/ten.teb.2012.0603

Recent advances in the fields of microfabrication, biomaterials, and tissue engineering have provided new opportunities for developing biomimetic and functional tissues with potential applications in disease modeling, drug discovery, and replacing da... Read More about Engineering functional epithelium for regenerative medicine and in vitro organ models: A review.

The development of a 3D immunocompetent model of human skin (2013)
Journal Article
Chau, D. Y., Johnson, C., MacNeil, S., Haycock, J. W., & Ghaemmaghami, A. M. (2013). The development of a 3D immunocompetent model of human skin. Biofabrication, 5(3), Article 035011. https://doi.org/10.1088/1758-5082/5/3/035011

As the first line of defence, skin is regularly exposed to a variety of biological, physical and chemical insults. Therefore, determining the skin sensitization potential of new chemicals is of paramount importance from the safety assessment and regu... Read More about The development of a 3D immunocompetent model of human skin.

Label-free separation and sorting of human monocytes and T-cells by electrowetting and dielectrophoresis (2013)
Presentation / Conference Contribution
Huang, C. Y., Chiang, M. Y., Fan, S. K., Ghaemmaghami, A. M., & Hsu, W. (2013). Label-free separation and sorting of human monocytes and T-cells by electrowetting and dielectrophoresis. In 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems (873-876). https://doi.org/10.1109/NEMS.2013.6559863

We report a label-free separation and sorting approach based on electrowetting-on-dielectric (EWOD) and dielectrophoresis (DEP) to manipulate human monocyte (THP-1) and T-cell (Jurkat) lines in droplets without any impact on cell viability. In additi... Read More about Label-free separation and sorting of human monocytes and T-cells by electrowetting and dielectrophoresis.

The role of lectins in allergic sensitization and allergic disease (2013)
Journal Article
Salazar, F., Sewell, H. F., Shakib, F., & Ghaemmaghami, A. M. (2013). The role of lectins in allergic sensitization and allergic disease. Journal of Allergy and Clinical Immunology, 132(1), 27-36. https://doi.org/10.1016/j.jaci.2013.02.001

Allergic diseases are a global public health issue affecting millions of persons around the world. However, full understanding of the molecular basis of this group of chronic inflammatory disorders remains rather elusive. Recently, the role of carboh... Read More about The role of lectins in allergic sensitization and allergic disease.

Electrospun PLGA fibre sheets incorporating fluorescent nanosensors: Self-reporting scaffolds for application in tissue engineering (2012)
Journal Article
Harrington, H. C., Rose, F. R., Reinwald, Y., Buttery, L. D., Ghaemmaghami, A. M., & Aylott, J. W. (2013). Electrospun PLGA fibre sheets incorporating fluorescent nanosensors: Self-reporting scaffolds for application in tissue engineering. Analytical Methods, 5(1), 68-71. https://doi.org/10.1039/c2ay25771h

Ratiometric analyte responsive nanosensors have been incorporated into electrospun poly(lactic-co-glycolic) acid (PLGA) fibres to create self-reporting scaffolds. It has been demonstrated that the self-reporting scaffolds could be utilised to monitor... Read More about Electrospun PLGA fibre sheets incorporating fluorescent nanosensors: Self-reporting scaffolds for application in tissue engineering.

Mammalian innate resistance to highly pathogenic avian influenza H5N1 virus infection is mediated through reduced proinflammation and infectious virus release (2012)
Journal Article
Nelli, R. K., Dunham, S. P., Kuchipudi, S. V., White, G. A., Baquero-Perez, B., Pengxiang, C., …Chang, K. (2012). Mammalian innate resistance to highly pathogenic avian influenza H5N1 virus infection is mediated through reduced proinflammation and infectious virus release. Journal of Virology, 86(17), https://doi.org/10.1128/JVI.00244-12

Respiratory epithelial cells and macrophages are the key innate immune cells that play an important role in the pathogenesis of influenza A virus infection. We found that these two cell types from both human and pig showed comparable susceptibilities... Read More about Mammalian innate resistance to highly pathogenic avian influenza H5N1 virus infection is mediated through reduced proinflammation and infectious virus release.