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Electrospun PLGA fibre sheets incorporating fluorescent nanosensors: Self-reporting scaffolds for application in tissue engineering

Harrington, H. C.; Rose, F. R.A.J.; Reinwald, Y.; Buttery, L. D.K.; Ghaemmaghami, A. M.; Aylott, J. W.

Authors

H. C. Harrington

F. R.A.J. Rose

Y. Reinwald

L. D.K. Buttery

J. W. Aylott



Abstract

Ratiometric analyte responsive nanosensors have been incorporated into electrospun poly(lactic-co-glycolic) acid (PLGA) fibres to create self-reporting scaffolds. It has been demonstrated that the self-reporting scaffolds could be utilised to monitor microenvironment conditions without damaging the fabricated scaffold or the cells being cultured upon the construct. This presents opportunities to fully understand, monitor and optimise the growth of 3D model tissue constructs in vitro. © 2013 The Royal Society of Chemistry.

Journal Article Type Article
Acceptance Date Nov 13, 2012
Online Publication Date Nov 27, 2012
Publication Date Jan 7, 2013
Deposit Date Jan 3, 2023
Journal Analytical Methods
Print ISSN 1759-9660
Electronic ISSN 1759-9679
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 5
Issue 1
Pages 68-71
DOI https://doi.org/10.1039/c2ay25771h
Public URL https://nottingham-repository.worktribe.com/output/3097452