All Outputs (2)

The molecular basis of allergenicity (2008)
Journal Article
Shakib, F., Ghaemmaghami, A. M., & Sewell, H. F. (2008). The molecular basis of allergenicity. Trends in Immunology, 29(12), 633-642. https://doi.org/10.1016/j.it.2008.08.007

Allergens are mostly innocuous antigens that elicit powerful T helper cell type 2 (Th2) responses leading to hyper-immunoglobulin E (IgE) production and allergy. Research carried out over several years has highlighted the possible role of the inheren... Read More about The molecular basis of allergenicity.

Allergen-driven suppression of thiol production by human dendritic cells and the effect of thiols on T cell function (2008)
Journal Article
Hasan, A. A., Ghaemmaghami, A. M., Fairclough, L., Robins, A., Sewell, H. F., & Shakib, F. (2009). Allergen-driven suppression of thiol production by human dendritic cells and the effect of thiols on T cell function. Immunobiology, 214(1), 2-16. https://doi.org/10.1016/j.imbio.2008.04.006

Dendritic cells are a major source of extracellular thiols needed for T cell activation, a process in which CD40-mediated stimulation plays a pivotal role. The Dermatophagoides pteronyssinus group 1 mite allergen (Der p 1) has previously been shown t... Read More about Allergen-driven suppression of thiol production by human dendritic cells and the effect of thiols on T cell function.