All Outputs (13)

Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins (2020)
Journal Article

© 2020, The Author(s). Cell biologists generally consider that microtubules and actin play complementary roles in long- and short-distance transport in animal cells. On the contrary, using melanosomes of melanocytes as a model, we recently discovered... Read More about Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins.

Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a (2019)
Journal Article

Rab GTPases are compartment-specific molecular switches that regulate intracellular vesicular transport in eukaryotes. GDP/GTP exchange factors (GEFs) control Rab activation, and current models propose that localised and regulated GEF activity is imp... Read More about Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a.

The adaptor protein melanophilin regulates dynamic myosin- Va: cargo interaction and dendrite development in melanocytes (2019)
Journal Article

Regulation of organelle transport by the cytoskeleton is fundamental for eukaryotic survival. Cytoskeleton motors are typically modular proteins with conserved motor and diverse cargo binding domains. Motor:cargo interactions are often indirect and m... Read More about The adaptor protein melanophilin regulates dynamic myosin- Va: cargo interaction and dendrite development in melanocytes.

Myosin Va’s adaptor protein melanophilin enforces track selection on the microtubule and actin networks in vitro (2017)
Journal Article

Inefficient recruitment of kinesin-1 to melanosomes precludes it from facilitating their transport (2017)
Journal Article

Microtubules and F-actin, and associated motor proteins, are considered to play complementary roles in long- and short-range organelle transport. However, there is growing appreciation that myosin/F-actin networks can drive long-range transport. In m... Read More about Inefficient recruitment of kinesin-1 to melanosomes precludes it from facilitating their transport.

Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes (2016)
Journal Article

There is growing evidence for a coupling of actin assembly and myosin motor activity in cells. However, mechanisms for recruitment of actin nucleators and motors on specific membrane compartments remain unclear. Here we report how Spir actin nucleato... Read More about Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes.

Correction: A Role for Na+,K+-ATPase ?1 in Regulating Rab27a Localisation on Melanosomes (2016)
Journal Article

Myosin--a monarch of pigment transport? (2015)
Journal Article

A role for Rab27 in neutrophil chemotaxis and lung recruitment (2014)
Journal Article

© 2014 Singh et al. Background: Neutrophils are a critical part of the innate immune system. Their ability to migrate into infected or injured tissues precedes their role in microbial killing and clearance. We have previously shown that Rab27a can pr... Read More about A role for Rab27 in neutrophil chemotaxis and lung recruitment.

Melanoma goes on a diet to get moving: toning down phagocytic Rab7 expression helps melanoma to metastasise (2014)
Journal Article

Myosin-Va and dynamic actin oppose microtubules to drive long-range organelle transport (2014)
Journal Article

In animal cells, microtubule and actin tracks and their associated motors (dynein, kinesin, and myosin) are thought to regulate long- and short-range transport, respectively [1-8]. Consistent with this, microtubules extend from the perinuclear centro... Read More about Myosin-Va and dynamic actin oppose microtubules to drive long-range organelle transport.

A role for Na+,K+-ATPase ?1 in regulating Rab27a localisation on melanosomes (2014)
Journal Article

The mechanism(s) by which Rab GTPases are specifically recruited to distinct intracellular membranes remains elusive. Here we used Rab27a localisation onto melanosomes as a model to investigate Rab targeting. We identified the α1 subunit of Na+,K+-AT... Read More about A role for Na+,K+-ATPase ?1 in regulating Rab27a localisation on melanosomes.

Rab11b mediates melanin transfer between donor melanocytes and acceptor keratinocytes via coupled exo/endocytosis (2013)
Journal Article

The transfer of melanin from melanocytes to keratinocytes is a crucial process underlying maintenance of skin pigmentation and photoprotection against UV damage. Here, we present evidence supporting coupled exocytosis of the melanin core, or melanoco... Read More about Rab11b mediates melanin transfer between donor melanocytes and acceptor keratinocytes via coupled exo/endocytosis.