B-cell receptors expressed by lymphomas of hepatitis C virus (HCV)-infected patients rarely react with the viral proteins

Ng, Patrick P.; BALL, JONATHAN; Kuo, Chiung-Chi; Wang, Stanley; Einav, Shirit; Arcaini, Luca; Paulli, Marco; Portlock, Carol S.; Marcotrigiano, Joseph; Tarr, Alexander; Levy, Ronald; Levy, Shoshana

doi:10.1182/blood-2013-10-532895

All Outputs (7)

Dramatic potentiation of the antiviral activity of HIV antibodies by cholesterol conjugation (2014)
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Type I interferon rapidly restricts infectious hepatitis C virus particle genesis (2014)
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Interferon-alpha (IFNα) has been used to treat chronic hepatitis C virus (HCV) infection for over 20 years with varying efficacy, depending on the infecting viral genotype. The mechanism of action of IFNα is not fully understood, but is thought to ta... Read More about Type I interferon rapidly restricts infectious hepatitis C virus particle genesis.

Recombinant Human L-Ficolin Directly Neutralizes Hepatitis C Virus Entry (2014)
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L-ficolin is a soluble pattern recognition molecule expressed by the liver that contributes to innate immune defense against microorganisms. It is well described that binding of L-ficolin to specific pathogen-associated molecular patterns activates t... Read More about Recombinant Human L-Ficolin Directly Neutralizes Hepatitis C Virus Entry.

Colicin import into E. coli cells: A model system for insights into the import mechanisms of bacteriocins (2014)
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Bacteriocins are a diverse group of ribosomally synthesized protein antibiotics produced by most bacteria. They range from small lanthipeptides produced by lactic acid bacteria to much larger multi domain proteins of Gram negative bacteria such as th... Read More about Colicin import into E. coli cells: A model system for insights into the import mechanisms of bacteriocins.

The past, present and future of neutralizing antibodies for hepatitis C virus (2014)
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Hepatitis C virus (HCV) is a major cause of liver disease and hepatocellular carcinoma worldwide. HCV establishes a chronic infection in the majority of cases. However, some individuals clear the virus, demonstrating a protective role for the host im... Read More about The past, present and future of neutralizing antibodies for hepatitis C virus.

Analysis of Serine Codon Conservation Reveals Diverse Phenotypic Constraints on Hepatitis C Virus Glycoprotein Evolution (2014)
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Serine is encoded by two divergent codon types, UCN and AGY, which are not interchangeable by a single nucleotide substitution. Switching between codon types therefore occurs via intermediates (threonine or cysteine) or via simultaneous tandem substi... Read More about Analysis of Serine Codon Conservation Reveals Diverse Phenotypic Constraints on Hepatitis C Virus Glycoprotein Evolution.

B-cell receptors expressed by lymphomas of hepatitis C virus (HCV)-infected patients rarely react with the viral proteins (2014)
Journal Article

Chronic hepatitis C virus (HCV) infection has been implicated in the induction and maintenance of B-cell lymphomas. The strongest evidence for this derives from clinical observations of tumor regressions upon antiviral treatments. Here we used multip... Read More about B-cell receptors expressed by lymphomas of hepatitis C virus (HCV)-infected patients rarely react with the viral proteins.