Identification of a broadly cross-reacting and neutralizing human monoclonal antibody directed against the hepatitis C virus E2 protein

Perotti, Mario; Mancini, Nicasio; Diotti, Roberta A.; Tarr, Alexander W.; Ball, Jonathan K.; Owsianka, Ania; Adair, R.; Patel, Arvind H.; Clementi, Massimo; Burioni, Roberto

doi:10.1128/JVI.01986-07

All Outputs (3)

Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein (2008)
Journal Article

The humoral response to hepatitis C virus (HCV) may contribute to controlling infection. We previously isolated human monoclonal antibodies to conformational epitopes on the HCV E2 glycoprotein. Here, we report on their ability to inhibit infection b... Read More about Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein.

Association of antibodies to hepatitis C virus glycoproteins 1 and 2 (anti-E1E2) with HCV disease (2008)
Journal Article

Hepatitis C virus (HCV) causes acute and chronic liver diseases in humans. Its two envelope glycoproteins, E1 and E2, provide a target for host immune recognition. HCV genotypes are classified into six genetic groups. To study the role of anti-HCV E1... Read More about Association of antibodies to hepatitis C virus glycoproteins 1 and 2 (anti-E1E2) with HCV disease.

Identification of a broadly cross-reacting and neutralizing human monoclonal antibody directed against the hepatitis C virus E2 protein (2008)
Journal Article

Identification of anti-hepatitis C virus (anti-HCV) human antibody clones with broad neutralizing activity is important for a better understanding of the interplay between the virus and host and for the design of an effective passive immunotherapy an... Read More about Identification of a broadly cross-reacting and neutralizing human monoclonal antibody directed against the hepatitis C virus E2 protein.