All Outputs (8)

A synthetic ancestral kinesin-13 depolymerizes microtubules faster than any natural depolymerizing kinesin (2022)
Journal Article

The activity of a kinesin is largely determined by the approximately 350 residue motor domain, and this region alone is sufficient to classify a kinesin as a member of a particular family. The kinesin-13 family are a group of microtubule depolymerizi... Read More about A synthetic ancestral kinesin-13 depolymerizes microtubules faster than any natural depolymerizing kinesin.

Distinct small non-coding RNA landscape in the axons and released extracellular vesicles of developing primary cortical neurons and the axoplasm of adult nerves (2021)
Journal Article

Neurons have highlighted the needs for decentralized gene expression and specific RNA function in somato-dendritic and axonal compartments, as well as in intercellular communication via extracellular vesicles (EVs). Despite advances in miRNA biology,... Read More about Distinct small non-coding RNA landscape in the axons and released extracellular vesicles of developing primary cortical neurons and the axoplasm of adult nerves.

Spatiotemporal regulation of GSK3? levels by miRNA-26a controls axon development in cortical neurons (2020)
Journal Article

© 2020. Published by The Company of Biologists Ltd. Both the establishment of neuronal polarity and axonal growth are crucial steps in the development of the nervous system. The local translation of mRNAs in the axon provides precise regulation of pr... Read More about Spatiotemporal regulation of GSK3? levels by miRNA-26a controls axon development in cortical neurons.

Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex (2019)
Journal Article

© 2019, Qu et al. Cortical collapse factors affect microtubule (MT) dynamics at the plasma membrane. They play important roles in neurons, as suggested by inhibition of axon growth and regeneration through the ARF activator Efa6 in C. elegans, and by... Read More about Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex.

The family-specific ?4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition (2016)
Journal Article

Kinesins that influence the dynamics of microtubule growth and shrinkage require the ability to distinguish between the microtubule end and the microtubule lattice. The microtubule depolymerizing kinesin MCAK has been shown to specifically recognize... Read More about The family-specific ?4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition.

Healthy ageing of cloned sheep (2016)
Journal Article

The health of cloned animals generated by somatic-cell nuclear transfer (SCNT) has been of concern since its inception; however, there are no detailed assessments of late-onset, non-communicable diseases. Here we report that SCNT has no obvious detri... Read More about Healthy ageing of cloned sheep.

Impact of voluntary exercise and housing conditions on hippocampal glucocorticoid receptor, miR-124 and anxiety (2015)
Journal Article

Background: Lack of physical activity and increased levels of stress contribute to the development of multiple physical and mental disorders. An increasing number of studies relate voluntary exercise with greater resilience to psychological stress, a... Read More about Impact of voluntary exercise and housing conditions on hippocampal glucocorticoid receptor, miR-124 and anxiety.

Use of stopped-flow fluorescence and labeled nucleotides to analyze the ATP turnover cycle of kinesins (2014)
Journal Article