Adaptation to HIF1a deletion in hypoxic cancer cells by upregulation of GLUT14 and creatine metabolism

Valli, Alessandro; Morotti, Matteo; Zois, Christos E.; Albers, Patrick K.; Soga, Tomoyoshi; Feldinger, Katharina; Fischer, Roman; Frejno, Martin; McIntyre, Alan; Bridges, Esther; Haider, Syed; Buffa, Francesca M.; Baban, Dilair; Rodriguez, Miguel; Yanes, Oscar; Whittington, Hannah J.; Lake, Hannah A.; Zervou, Sevasti; Lygate, Craig A.; Kessler, Benedikt M.; Harris, Adrian L.

doi:10.1158/1541-7786.MCR-18-0315

All Outputs (2)

Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer (2019)
Journal Article

Tumor hypoxia is associated with poor patient outcomes in estrogen receptor-α–positive (ERα+) breast cancer. Hypoxia is known to affect tumor growth by reprogramming metabolism and regulating amino acid (AA) uptake. Here, we show that the glutamine t... Read More about Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer.

Adaptation to HIF1a deletion in hypoxic cancer cells by upregulation of GLUT14 and creatine metabolism (2019)
Journal Article

© 2019 American Association for Cancer Research. Hypoxia-inducible factor 1a is a key regulator of the hypoxia response in normal and cancer tissues. It is well recognized to regulate glycolysis and is a target for therapy. However, how tumor cells a... Read More about Adaptation to HIF1a deletion in hypoxic cancer cells by upregulation of GLUT14 and creatine metabolism.