All Outputs (2)

The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular salmonella typhimurium (2012)
Journal Article
Huett, A., Heath, R. J., Begun, J., Sassi, S. O., Baxt, L. A., Vyas, J. M., …Xavier, R. J. (2012). The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular salmonella typhimurium. Cell Host and Microbe, 12(6), 778-790. https://doi.org/10.1016/j.chom.2012.10.019

Several species of pathogenic bacteria replicate within an intracellular vacuolar niche. Bacteria that escape into the cytosol are captured by the autophagic pathway and targeted for lysosomal degradation, representing a defense against bacterial exp... Read More about The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular salmonella typhimurium.

Tribbles 2 (Trib2) is a novel regulator of toll-like receptor 5 signaling (2012)
Journal Article
Wei, S. C., Rosenberg, I. M., Cao, Z., Huett, A. S., Xavier, R. J., & Podolsky, D. K. (2012). Tribbles 2 (Trib2) is a novel regulator of toll-like receptor 5 signaling. Inflammatory Bowel Diseases, 18(5), 877-888. https://doi.org/10.1002/ibd.22883

Background: Toll-like receptors (TLRs) are expressed by a variety of cells, including intestinal epithelia. However, the full spectrum of regulators modulating innate responses via TLRs has not been delineated. Tribbles (Trib) have been identified as... Read More about Tribbles 2 (Trib2) is a novel regulator of toll-like receptor 5 signaling.