Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

Rioux, John D.; Xavier, Ramnik J.; Taylor, Kent D.; Silverberg, Mark S.; Goyette, Philippe; Huett, Alan; Green, Todd; Kuballa, Petric; Barmada, M. Michael; Datta, Lisa Wu; Shugart, Yin Yao; Griffiths, Anne M.; Targan, Stephan R.; Ippoliti, Andrew F.; Bernard, Edmond Jean; Mei, Ling; Nicolae, Dan L.; Regueiro, Miguel; Schumm, L. Philip; Steinhart, A. Hillary; Rotter, Jerome I.; Duerr, Richard H.; Cho, Judy H.; Daly, Mark J.; Brant, Steven R.

doi:10.1038/ng2032

All Outputs (4)

SNPping away at the pathogenesis of Crohn's disease (2007)
Journal Article

DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact (2007)
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PDZ domain containing molecular scaffolds plays a central role in organizing synaptic junctions. Observations in Drosophila and mammalian cells have implicated that ubiquitination and endosomal trafficking, of molecular scaffolds are critical to the... Read More about DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact.

DLGH1 is a negative regulator of T-lymphocyte proliferation (2007)
Journal Article

Discs large homolog 1 (DLGH1), a founding member of the membrane-associated guanylate kinase family of proteins containing Postsynaptic Density-95/Discs large/Zona Occludens-1 domains, is an ortholog of the Drosophila tumor suppressor gene Discs larg... Read More about DLGH1 is a negative regulator of T-lymphocyte proliferation.

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis (2007)
Journal Article

We present a genome-wide association study of ileal Crohn disease and two independent replication studies that identify several new regions of association to Crohn disease. Specifically, in addition to the previously established CARD15 and IL23R asso... Read More about Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.