Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

Rioux, John D.; Xavier, Ramnik J.; Taylor, Kent D.; Silverberg, Mark S.; Goyette, Philippe; Huett, Alan; Green, Todd; Kuballa, Petric; Barmada, M. Michael; Datta, Lisa Wu; Shugart, Yin Yao; Griffiths, Anne M.; Targan, Stephan R.; Ippoliti, Andrew F.; Bernard, Edmond Jean; Mei, Ling; Nicolae, Dan L.; Regueiro, Miguel; Schumm, L. Philip; Steinhart, A. Hillary; Rotter, Jerome I.; Duerr, Richard H.; Cho, Judy H.; Daly, Mark J.; Brant, Steven R.

doi:10.1038/ng2032

All Outputs (4)

SNPping away at the pathogenesis of Crohn's disease (2007)
Journal Article
Huett, A., & Xavier, R. (2008). SNPping away at the pathogenesis of Crohn's disease. Inflammatory Bowel Diseases, 14(1), 136-137. https://doi.org/10.1002/ibd.20306

DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact (2007)
Journal Article
Cao, Z., Huett, A., Kuballa, P., Giallourakis, C., & Xavier, R. J. (2008). DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact. Cellular Signalling, 20(1), 73-82. https://doi.org/10.1016/j.cellsig.2007.08.019

PDZ domain containing molecular scaffolds plays a central role in organizing synaptic junctions. Observations in Drosophila and mammalian cells have implicated that ubiquitination and endosomal trafficking, of molecular scaffolds are critical to the... Read More about DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact.

DLGH1 is a negative regulator of T-lymphocyte proliferation (2007)
Journal Article
Stephenson, L. M., Sammut, B., Graham, D. B., Chan-Wang, J., Brim, K. L., Huett, A. S., …Swat, W. (2007). DLGH1 is a negative regulator of T-lymphocyte proliferation. Molecular and Cellular Biology, 27(21), 7574-7581. https://doi.org/10.1128/MCB.00439-07

Discs large homolog 1 (DLGH1), a founding member of the membrane-associated guanylate kinase family of proteins containing Postsynaptic Density-95/Discs large/Zona Occludens-1 domains, is an ortholog of the Drosophila tumor suppressor gene Discs larg... Read More about DLGH1 is a negative regulator of T-lymphocyte proliferation.

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis (2007)
Journal Article
Rioux, J. D., Xavier, R. J., Taylor, K. D., Silverberg, M. S., Goyette, P., Huett, A., …Brant, S. R. (2007). Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nature Genetics, 39(5), 596-604. https://doi.org/10.1038/ng2032

We present a genome-wide association study of ileal Crohn disease and two independent replication studies that identify several new regions of association to Crohn disease. Specifically, in addition to the previously established CARD15 and IL23R asso... Read More about Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.