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Antibiotic spider silk: site-specific functionalisation of recombinant spider silk using ‘click’- chemistry (2016)
Journal Article
Harvey, D., Bardelang, P., Goodacre, S., Cockayne, A., & Thomas, N. R. (2017). Antibiotic spider silk: site-specific functionalisation of recombinant spider silk using ‘click’- chemistry. Advanced Materials, 29(10), doi:10.1002/adma.201604245

The use of functionalised recombinant spider silk as a sustainable advanced biomaterial is currently an area of intense interest owing to spider silk’s intrinsic strength, toughness, biocompatibility and biodegradability. This paper demonstrates, for... Read More

Pathogenesis of C. difficile and its potential role in inflammatory bowel disease (2015)
Journal Article
Monaghan, T., Cockayne, A., & Mahidi, Y. R. (2015). Pathogenesis of C. difficile and its potential role in inflammatory bowel disease. Inflammatory Bowel Diseases, 21(8), 1957-1966. doi:10.1097/MIB.0000000000000461

Colonization with toxigenic Clostridium difficile may be associated with a wide spectrum of clinical presentation ranging from asymptomatic carriage to mild diarrhea to life-threatening colitis. Over the last 15 years, there has been a marked increas... Read More

Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors (2014)
Journal Article
Murray, E. J., Crowley, R. C., Truman, A., Clarke, S. R., Cottam, J. A., Jadhav, G. P., …Williams, P. (2014). Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors. Journal of Medicinal Chemistry, 57(6), doi:10.1021/jm500215s. ISSN 0022-2623

A series of 3-oxo-C12-HSL, tetramic acid, and tetronic acid analogues were synthesized to gain insights into the structural requirements for quorum sensing inhibition in Staphylococcus aureus. Compounds active against agr were noncompetitive inhibito... Read More

Importance of Toxin A, Toxin B, and CDT in virulence of an epidemic Clostridium difficile strain (2013)
Journal Article
Kuehne, S. A., Collery, M. M., Kelly, M. L., Cartman, S. T., Cockayne, A., & Minton, N. P. (in press). Importance of Toxin A, Toxin B, and CDT in virulence of an epidemic Clostridium difficile strain. Journal of Infectious Diseases, 209(1), doi:10.1093/infdis/jit426. ISSN 0022-1899

Clostridium difficile infection is the main cause of healthcare-acquired diarrhea in the developed world. In addition to the main virulence factors toxin A and B, epidemic, PCR Ribotype 027 strains, such as R20291, produce a third toxin, CDT. To deve... Read More

Combinatorial discovery of polymers resistant to bacterial attachment (2012)
Journal Article
Hook, A. L., Chang, C., Yang, J., Luckett, J., Cockayne, A., Atkinson, S., …Alexander, M. R. (2012). Combinatorial discovery of polymers resistant to bacterial attachment. Nature Biotechnology, 30(9), doi:10.1038/nbt.2316. ISSN 1087-0156

Bacterial attachment and subsequent biofilm formation are key challenges to the long term performance of many medical devices. Here, a high throughput approach coupled with the analysis of surface structure-property relationships using a chemometics... Read More