Research Repository

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Synthetic light-curable polymeric materials provide a supportive niche for dental pulp stem cells (2017)
Journal Article
Vining, K. H., Scherba, J. C., Bever, A., Alexander, M. R., Celiz, A. D., & Mooney, D. J. (2018). Synthetic light-curable polymeric materials provide a supportive niche for dental pulp stem cells. Advanced Materials, 30(4), doi:10.1002/adma.201704486. ISSN 0935-9648

Dental disease annually affects billions of patients, and while regenerative dentistry aims to heal dental tissue after injury, existing polymeric restorative materials, or fillings, do not directly participate in the healing process in a bioinstruct... Read More

Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation (2015)
Journal Article
Celiz, A. D., Smith, J. G., Patel, A. K., Hook, A. L., Rajamohan, D., George, V. T., …Alexander, M. R. (2015). Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation. Advanced Materials, 27(27), doi:10.1002/adma.201501351. ISSN 0935-9648

A scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to... Read More

Materials for stem cell factories of the future (2014)
Journal Article
Celiz, A. D., Smith, J. G., Langer, R., Anderson, D. G., Barrett, D. A., Winkler, D. A., …Alexander, M. R. (in press). Materials for stem cell factories of the future. Nature Materials, 13(6), doi:10.1038/nmat3972. ISSN 1476-1122

The materials community is now identifying polymeric substrates that could permit translation of human pluripotent stem cells (hPSCs) from lab-based research to industrial scale biomedicine. Well defined materials are required to allow cell banking a... Read More

High throughput screening for discovery of materials that control stem cell fate
Journal Article
Patel, A. K., Tibbitt, M., Celiz, A. D., Davies, M. C., Langer, R., Denning, C., …Anderson, D. G. (2016). High throughput screening for discovery of materials that control stem cell fate. Current Opinion in Solid State and Materials Science, doi:10.1016/j.cossms.2016.02.002. ISSN 1359-0286

Insights into the complex stem cell niche have identified the cell–material interface to be a potent regulator of stem cell fate via material properties such as chemistry, topography and stiffness. In light of this, materials scientists have the oppo... Read More