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The impact of azithromycin therapy on the airway microbiota in asthma

Slater, Mariel; Rivett, Damian W.; Williams, Lisa; Martin, Matthew; Harrison, Timothy W.; Sayers, Ian; Bruce, Kenneth D.; Shaw, Dominick E.

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Authors

Mariel Slater

Damian W. Rivett

Lisa Williams

Matthew Martin

Timothy W. Harrison

Kenneth D. Bruce

Dominick E. Shaw



Abstract

There is interest in the use of macrolide antibiotics in asthma. Macrolides have been shown to improve airway hyperresponsiveness (AHR) and measures of airway inflammation.The degree of AHR may relate to the microbiota present in the airways, with a recent study reporting that patients with asthma with a significant improvement in AHR following treatment with clarithromycin had a higher bacterial diversity prior to treatment. To our knowledge, the impact on the asthmatic airway microbiota of an antibiotic has not been reported and we therefore set out to establish if macrolide therapy was associated with a change in airway microbiota in asthma.

Journal Article Type Article
Publication Date Jul 1, 2014
Deposit Date Apr 5, 2016
Publicly Available Date Apr 5, 2016
Journal Thorax
Print ISSN 0040-6376
Electronic ISSN 1468-3296
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 69
Issue 7
DOI https://doi.org/10.1136/thoraxjnl-2013-204517
Public URL https://nottingham-repository.worktribe.com/output/995502
Publisher URL http://dx.doi.org/10.1136/thoraxjnl-2013-204517

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