Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes

Falconer, C.L.; Cooper, A.R.; Walhin, J.P.; Thompson, D.; Page, A.S.; Peters, T.J.; Montgomery, A.A.; Sharp, D.J.; Dayan, C.M.; Andrews, R.C.

Abstract

Background and aims:
We investigated whether objectively measured sedentary time was associated with markers of inflammation in adults with newly diagnosed type 2 diabetes.

Methods and results:
We studied 285 adults (184 men, 101 women, mean age 59.0 ± 9.7) who had been recruited to the Early ACTivity in Diabetes (Early ACTID) randomised controlled trial. C-reactive protein (CRP), adiponectin, soluble intracellular adhesion molecule-1 (sICAM-1), interleukin-6 (IL-6), and accelerometer-determined sedentary time and moderate-vigorous physical activity (MVPA) were measured at baseline and after six-months. Linear regression analysis was used to investigate the independent cross-sectional and longitudinal associations of sedentary time with markers of inflammation. At baseline, associations between sedentary time and IL-6 were observed in men and women, an association that was attenuated following adjustment for waist circumference. After 6 months of follow-up, sedentary time was reduced by 0.4 ± 1.2 h per day in women, with the change in sedentary time predicting CRP at follow-up. Every hour decrease in sedentary time between baseline and six-months was associated with 24% (1, 48) lower CRP. No changes in sedentary time between baseline and 6 months were seen in men.

Conclusions:
Higher sedentary time is associated with IL-6 in men and women with type 2 diabetes, and reducing sedentary time is associated with improved levels of CRP in women. Interventions to reduce sedentary time may help to reduce inflammation in women with type 2 diabetes.

Citation

Falconer, C., Cooper, A., Walhin, J., Thompson, D., Page, A., Peters, T., Montgomery, A., Sharp, D., Dayan, C., & Andrews, R. (2014). Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes. Nutrition, Metabolism and Cardiovascular Diseases, 2014(24(9)), https://doi.org/10.1016/j.numecd.2014.03.009

• Journal Article Type: Article
• Acceptance Date: Mar 20, 2014
• Online Publication Date: Apr 26, 2014
• Publication Date: Sep 1, 2014
• Deposit Date: Sep 19, 2017
• Publicly Available Date: Sep 19, 2017
• Journal: Nutrition, Metabolism and Cardiovascular Diseases
• Print ISSN: 0939-4753
• Electronic ISSN: 0939-4753
• Publisher: Elsevier
• Peer Reviewed: Not Peer Reviewed
• Volume: 2014
• Issue: 24(9)
• DOI: https://doi.org/10.1016/j.numecd.2014.03.009
• Keywords: Sedentary time; Type 2 diabetes; Breaks in sedentary time; Inflammation
• Public URL: https://nottingham-repository.worktribe.com/output/994462
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S093947531400129X
• Contract Date: Sep 19, 2017