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Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes

Falconer, C.L.; Cooper, A.R.; Walhin, J.P.; Thompson, D.; Page, A.S.; Peters, T.J.; Montgomery, A.A.; Sharp, D.J.; Dayan, C.M.; Andrews, R.C.

Authors

C.L. Falconer

A.R. Cooper

J.P. Walhin

D. Thompson

A.S. Page

T.J. Peters

ALAN MONTGOMERY ALAN.MONTGOMERY@NOTTINGHAM.AC.UK
Director, nottingham Clinical Trials Unit

D.J. Sharp

C.M. Dayan

R.C. Andrews



Abstract

Background and aims:
We investigated whether objectively measured sedentary time was associated with markers of inflammation in adults with newly diagnosed type 2 diabetes.

Methods and results:
We studied 285 adults (184 men, 101 women, mean age 59.0 ± 9.7) who had been recruited to the Early ACTivity in Diabetes (Early ACTID) randomised controlled trial. C-reactive protein (CRP), adiponectin, soluble intracellular adhesion molecule-1 (sICAM-1), interleukin-6 (IL-6), and accelerometer-determined sedentary time and moderate-vigorous physical activity (MVPA) were measured at baseline and after six-months. Linear regression analysis was used to investigate the independent cross-sectional and longitudinal associations of sedentary time with markers of inflammation. At baseline, associations between sedentary time and IL-6 were observed in men and women, an association that was attenuated following adjustment for waist circumference. After 6 months of follow-up, sedentary time was reduced by 0.4 ± 1.2 h per day in women, with the change in sedentary time predicting CRP at follow-up. Every hour decrease in sedentary time between baseline and six-months was associated with 24% (1, 48) lower CRP. No changes in sedentary time between baseline and 6 months were seen in men.

Conclusions:
Higher sedentary time is associated with IL-6 in men and women with type 2 diabetes, and reducing sedentary time is associated with improved levels of CRP in women. Interventions to reduce sedentary time may help to reduce inflammation in women with type 2 diabetes.

Citation

Falconer, C., Cooper, A., Walhin, J., Thompson, D., Page, A., Peters, T., …Andrews, R. (2014). Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes. Nutrition, Metabolism and Cardiovascular Diseases, 2014(24(9)), https://doi.org/10.1016/j.numecd.2014.03.009

Journal Article Type Article
Acceptance Date Mar 20, 2014
Online Publication Date Apr 26, 2014
Publication Date Sep 1, 2014
Deposit Date Sep 19, 2017
Publicly Available Date Sep 19, 2017
Journal Nutrition, Metabolism and Cardiovascular Diseases
Print ISSN 0939-4753
Electronic ISSN 0939-4753
Publisher Elsevier
Peer Reviewed Not Peer Reviewed
Volume 2014
Issue 24(9)
DOI https://doi.org/10.1016/j.numecd.2014.03.009
Keywords Sedentary time; Type 2 diabetes; Breaks in sedentary time; Inflammation
Public URL http://eprints.nottingham.ac.uk/id/eprint/46470
Publisher URL http://www.sciencedirect.com/science/article/pii/S093947531400129X
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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