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A Thermoresponsive and Magnetic Colloid for 3D Cell Expansion and Reconfiguration

Saunders, Brian R.; Gould, Toby; Saeed, Aram Omer; Francini, Nora; White, Lisa; Dixon, James E.; Gould, Toby W.A.; Rashidi, Hassan; Al Ghanami, Racha Cheikh; Hruschka, Veronika; Redl, Heinz; Saunders, Brian R; Alexander, Cameron; Shakesheff, Kevin M.

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Authors

Brian R. Saunders

Toby Gould

Aram Omer Saeed

Nora Francini

JAMES DIXON JAMES.DIXON@NOTTINGHAM.AC.UK
Associate Professor

Toby W.A. Gould

Hassan Rashidi

Racha Cheikh Al Ghanami

Veronika Hruschka

Heinz Redl

Brian R Saunders

Kevin M. Shakesheff



Abstract

A dual thermoresponsive and magnetic colloidal gel matrix is described for enhanced stem-cell culture. The combined properties of the material allow enzyme-free passaging and expansion of mesenchymal stem cells, as well as isolation of cells postculture by the simple process of lowering the temperature and applying an external magnetic field. The colloidal gel can be reconfigured with thermal and magnetic stimuli to allow patterning of cells in discrete zones and to control movement of cells within the porous matrix during culture.

Journal Article Type Article
Online Publication Date Nov 29, 2014
Publication Date 2015-01
Deposit Date Jun 12, 2015
Publicly Available Date Jun 12, 2015
Journal Advanced Materials
Print ISSN 0935-9648
Electronic ISSN 0935-9648
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 27
Issue 4
Pages 662-668
DOI https://doi.org/10.1002/adma.201403626
Keywords responsive polymers, tissue engineering, regenerative medicine, stem cell culture
Public URL https://nottingham-repository.worktribe.com/output/992989
Publisher URL http://onlinelibrary.wiley.com/doi/10.1002/adma.201403626/full

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