Attenuated post-movement beta rebound associated with schizotypal features in healthy people

Hunt, Benjamin A.E.; Liddle, Elizabeth B.; Gascoyne, Lauren E.; Magazzini, Lorenzo; Routley, Bethany C.; Singh, Krish D.; Morris, Peter G.; Brookes, Matthew J.; Liddle, Peter F.

Abstract

© The Author(s) 2018. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. Introduction: Schizophrenia and schizotypal personality disorder (SPD) lie on a single spectrum of mental illness and converging evidence suggests similarities in the etiology of the 2 conditions. However, schizotypy is a heterogeneous facet of personality in the healthy population and so may be seen as a bridge between health and mental illness. Neural evidence for such a continuity would have implications for the characterization and treatment of schizophrenia. Based on our previous work identifying a relationship between symptomology in schizophrenia and abnormal movement-induced electrophysiological response (the post-movement beta rebound [PMBR]), we predicted that if subclinical schizotypy arises from similar neural mechanisms to schizophrenia, schizotypy in healthy individuals would be associated with reduced PMBR. Methods: One-hundred sixteen participants completed a visuomotor task while their neural activity was recorded by magnetoencephalography. Partial correlations were computed between a measure of PMBR extracted from left primary motor cortex and scores on the Schizotypal Personality Questionnaire (SPQ), a self-report measure of schizotypal personality. Correlations between PMBR and SPQ factor scores measuring cognitive-perceptual, interpersonal and disorganization dimensions of schizotypy were also computed. Effects of site, age, and sex were controlled for. Results: We found a significant negative correlation between total SPQ score and PMBR. This was most strongly mediated by variance shared between interpersonal and disorganization factor scores. Conclusion: These findings indicate a continuum of neural deficit between schizotypy and schizophrenia, with diminution of PMBR, previously reported in schizophrenia, also measurable in individuals with schizotypal features, particularly disorganization and impaired interpersonal relations.

Citation

Hunt, B. A., Liddle, E. B., Gascoyne, L. E., Magazzini, L., Routley, B. C., Singh, K. D., …Liddle, P. F. (2019). Attenuated post-movement beta rebound associated with schizotypal features in healthy people. Schizophrenia Bulletin, 45(4), 883-891. https://doi.org/10.1093/schbul/sby117

• Journal Article Type: Article
• Acceptance Date: Jul 31, 2018
• Online Publication Date: Sep 18, 2018
• Publication Date: Jan 1, 2019
• Deposit Date: Aug 10, 2018
• Publicly Available Date: Nov 19, 2018
• Journal: Schizophrenia Bulletin
• Print ISSN: 0586-7614
• Electronic ISSN: 1745-1701
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 45
• Issue: 4
• Pages: 883-891
• DOI: https://doi.org/10.1093/schbul/sby117
• Keywords: Magnetoencephalography; Schizotypy; Schizophrenia; Individual Differences; Schizotypal Personality Disorder; Psychosis
• Public URL: https://nottingham-repository.worktribe.com/output/988730
• Publisher URL: https://academic.oup.com/schizophreniabulletin/advance-article/doi/10.1093/schbul/sby117/5095481?rss=1
• Contract Date: Aug 10, 2018